2006
Barrel Map Development Relies on Protein Kinase A Regulatory Subunit IIβ-Mediated cAMP Signaling
Inan M, Lu HC, Albright MJ, She WC, Crair MC. Barrel Map Development Relies on Protein Kinase A Regulatory Subunit IIβ-Mediated cAMP Signaling. Journal Of Neuroscience 2006, 26: 4338-4349. PMID: 16624954, PMCID: PMC6674004, DOI: 10.1523/jneurosci.3745-05.2006.Peer-Reviewed Original ResearchConceptsBarrel map formationLayer IV neuronsActivity-dependent developmentAMPA receptor functionCAMP/PKA-dependent pathwayLong-term potentiationThalamocortical synapsesThalamocortical afferentsTC synapsesThalamocortical synapseBarrel cortexPKA targetsBarrel patternCortical developmentPKA-dependent pathwayBrain circuitryPostsynaptic processesSynapse formationReceptor functionCAMP-dependent protein kinaseHebbian mechanismsDevelopmental increaseMiceSynapsesActivity-dependent models
1999
The Nuclear Orphan Receptor COUP-TFI Is Required for Differentiation of Subplate Neurons and Guidance of Thalamocortical Axons
Zhou C, Qiu Y, Pereira F, Crair M, Tsai S, Tsai M. The Nuclear Orphan Receptor COUP-TFI Is Required for Differentiation of Subplate Neurons and Guidance of Thalamocortical Axons. Neuron 1999, 24: 847-859. PMID: 10624948, DOI: 10.1016/s0896-6273(00)81032-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntimetabolitesAxonsBromodeoxyuridineCarbocyaninesCell DeathCell DifferentiationCerebral CortexCOUP Transcription Factor IDNA-Binding ProteinsFluorescent DyesImmunohistochemistryIn Situ HybridizationMaleMiceMutationNeural PathwaysNeuronsReceptors, GlucocorticoidThalamusTranscription FactorsConceptsSubplate neuronsThalamocortical projectionsCortical layer IVLayer IV neuronsCell deathCorticothalamic connectivityAfferent innervationCerebral cortexThalamocortical axonsLayer IVNervous systemExcessive cell deathFactor INeuronal developmentNeuronsNuclear receptorsPremature cell deathInnervationImproper differentiationImportant regulatorOrphan memberDeathCritical roleDifferentiationFailure