2011
Development of Single Retinofugal Axon Arbors in Normal and β2 Knock-Out Mice
Dhande OS, Hua EW, Guh E, Yeh J, Bhatt S, Zhang Y, Ruthazer ES, Feller MB, Crair MC. Development of Single Retinofugal Axon Arbors in Normal and β2 Knock-Out Mice. Journal Of Neuroscience 2011, 31: 3384-3399. PMID: 21368050, PMCID: PMC3060716, DOI: 10.1523/jneurosci.4899-10.2011.Peer-Reviewed Original ResearchConceptsDorsal lateral geniculate nucleusRetinal ganglion cellsSuperior colliculusAxon arborsRetinotopic refinementEye-specific segregationReceptor mutant miceLateral geniculate nucleusActivity-dependent mechanismsNormal developmentWT miceRGC axonsRetinal wavesGanglion cellsGeniculate nucleusMutant miceRole of activityMiceSpecific cuesArborsSparse branchesSame ageLabeling techniqueMaturationDevelopmental period
2005
Evidence for an Instructive Role of Retinal Activity in Retinotopic Map Refinement in the Superior Colliculus of the Mouse
Chandrasekaran AR, Plas DT, Gonzalez E, Crair MC. Evidence for an Instructive Role of Retinal Activity in Retinotopic Map Refinement in the Superior Colliculus of the Mouse. Journal Of Neuroscience 2005, 25: 6929-6938. PMID: 16033903, PMCID: PMC6725341, DOI: 10.1523/jneurosci.1470-05.2005.Peer-Reviewed Original ResearchConceptsRetinotopic map refinementRetinal activitySuperior colliculusActivity-dependent factorsNasal-temporal axisSpontaneous retinal activityWild-type miceActivity-dependent cuesActivity-dependent mechanismsRetinotopic map developmentAxon guidance cuesGuidance cuesMolecular mechanismsRetinal wavesPharmacological interventionsMouse modelRetinotopic mapColliculusSame animalsMicePreferential roleReceptive fieldsPhysiological methodsInstructive roleMap refinement
2003
Adenylyl cyclase I regulates AMPA receptor trafficking during mouse cortical 'barrel' map development
Lu HC, She WC, Plas DT, Neumann PE, Janz R, Crair MC. Adenylyl cyclase I regulates AMPA receptor trafficking during mouse cortical 'barrel' map development. Nature Neuroscience 2003, 6: 939-947. PMID: 12897788, DOI: 10.1038/nn1106.Peer-Reviewed Original ResearchConceptsLong-term depressionLong-term potentiationAMPA receptor traffickingThalamocortical synapsesBarrelless miceBarrel map formationSynaptic AMPAR traffickingAMPAR subunit GluR1Activity-dependent mechanismsReceptor traffickingAC1 activityFunctional AMPARsSurface GluR1Thalamocortical afferentsMap formationAdenylyl cyclase IBarrel mapSubunit GluR1Cortical map formationAMPAR traffickingProtein kinase A (PKA) activitySynapsesAdenylyl cyclaseMiceImmature state
1997
Silent Synapses during Development of Thalamocortical Inputs
Isaac J, Crair M, Nicoll R, Malenka R. Silent Synapses during Development of Thalamocortical Inputs. Neuron 1997, 18: 269-280. PMID: 9052797, DOI: 10.1016/s0896-6273(00)80267-6.Peer-Reviewed Original ResearchConceptsLong-term potentiationThalamocortical synapsesThalamocortical inputsSilent synapsesFunctional synapsesPostnatal day 8Rat somatosensory cortexActivity-dependent mechanismsActivity-dependent increaseEarly postnatal developmentSomatosensory cortexPostsynaptic activityTopographical projectionDay 8Postnatal developmentSynaptic connectionsSynaptic strengthSynapsesCortexSignificant proportionThalamusEarly developmentPotentiation