1997
A Tyrosine-Based Signal Targets H/K-ATPase to a Regulated Compartment and Is Required for the Cessation of Gastric Acid Secretion
Courtois-Coutry N, Roush D, Rajendran V, McCarthy J, Geibel J, Kashgarian M, Caplan M. A Tyrosine-Based Signal Targets H/K-ATPase to a Regulated Compartment and Is Required for the Cessation of Gastric Acid Secretion. Cell 1997, 90: 501-510. PMID: 9267030, DOI: 10.1016/s0092-8674(00)80510-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCOS CellsCytomegalovirusDNA PrimersEndocytosisGastric AcidGastric MucosaH(+)-K(+)-Exchanging ATPaseMacromolecular SubstancesMiceMice, TransgenicMicroscopy, ImmunoelectronMutagenesis, Site-DirectedParietal Cells, GastricPolymerase Chain ReactionPromoter Regions, GeneticRecombinant ProteinsSignal TransductionTransfectionTyrosineConceptsK-ATPase beta subunitTyrosine-based signalsK-ATPaseTyrosine-based endocytosis signalTyrosine residuesBeta subunitIntracellular storage compartmentEndocytosis signalCytoplasmic tailMutant betaRegulated compartmentsSecrete acidResidue sequenceStorage compartmentCell surfaceCell plasmalemmaSubunitsTransgenic miceParietal cellsGastric glandsCompartmentsSecretionAcid secretionReinternalizationPlasmalemmaMembrane polarity in epithelial cells: protein sorting and establishment of polarized domains
Caplan MJ. Membrane polarity in epithelial cells: protein sorting and establishment of polarized domains. American Journal Of Physiology 1997, 272: f425-f429. PMID: 9140041, DOI: 10.1152/ajprenal.1997.272.4.f425.Peer-Reviewed Original ResearchConceptsTransport proteinsEpithelial cellsDistinct surface domainsEpithelial cell typesProtein sortingBiological specializationCellular pathwaysPlasma membranePolarized epitheliumElegant networkMembrane polarityCell typesBasolateral surfaceDistinct populationsProteinBasolateral portionPhysiological propertiesSurface domainsCellsAbsolute prerequisiteDomainPlasmalemmaPathwaySortingMembrane
1994
Chapter 8 Synthesis and Sorting of Ion Pumps in Polarized Cells
Gottardi C, Pietrini G, Shiel M, Caplan M. Chapter 8 Synthesis and Sorting of Ion Pumps in Polarized Cells. Current Topics In Membranes 1994, 41: 143-168. DOI: 10.1016/s0070-2161(08)60458-x.Peer-Reviewed Original ResearchDistinct biochemical compositionsCellular polarityIntercellular junctional complexesPolarized cellsTertiary structureCellular componentsBiologic contextCell typesTerm polarityJunctional complexesIon pumpsBiochemical compositionProteinAppropriate localizationMachineryDistinguishable domainsSeparate body compartmentsFunctional propertiesCellsPolarityPlasmalemmaSortingCompartmentsMembraneEvidence of polarity
1991
Chapter 2 Biogenesis and Sorting of Plasma Membrane Proteins
Caplan M. Chapter 2 Biogenesis and Sorting of Plasma Membrane Proteins. Current Topics In Membranes 1991, 39: 37-86. PMCID: PMC7128438, DOI: 10.1016/s0070-2161(08)60800-x.Peer-Reviewed Original ResearchPlasma membrane proteinsPlasma membraneMembrane proteinsCell typesCell surfacePolarized epithelial cellsApical plasma membraneDistribution of polypeptidesExpression of genesCell surface membraneTransducer proteinsAnchor cellCell biologyProtein compositionProteinMost cellsBiogenesisFascinating questionsPlasmalemmal receptorsOrganellesEpithelial cellsSurface membranePolypeptideMembranePlasmalemma
1987
Processing and Sorting of Proteins Synthesized in the Endoplasmic Reticulum
Caplan M, Rosenzweig S, Jamieson J. Processing and Sorting of Proteins Synthesized in the Endoplasmic Reticulum. 1987, 273-281. DOI: 10.1007/978-1-4613-1943-6_16.Peer-Reviewed Original ResearchIntracellular membrane-bounded compartmentsEndoplasmic reticulumSorting of proteinsRough endoplasmic reticulumMembrane-bounded compartmentsIntracellular digestion processSpecialized functional domainsEukaryotic cellsMembrane proteinsFunctional domainsSecretory proteinsIntracellular compartmentsLysosomal hydrolasesProteinExtracellular spaceMajor classesReticulumCompartmentsBiogenesisCommon setCellsHydrolasesPlasmalemmaDigestion processSorting
1986
Processing and Sorting of Proteins Synthesized in the Endoplasmic Reticulum
Caplan M, Rosenzweig S, Jamieson J. Processing and Sorting of Proteins Synthesized in the Endoplasmic Reticulum. 1986, 273-281. DOI: 10.1007/978-1-4613-2097-5_16.Peer-Reviewed Original ResearchIntracellular membrane-bounded compartmentsEndoplasmic reticulumSorting of proteinsRough endoplasmic reticulumMembrane-bounded compartmentsIntracellular digestion processSpecialized functional domainsEukaryotic cellsMembrane proteinsFunctional domainsSecretory proteinsIntracellular compartmentsLysosomal hydrolasesProteinExtracellular spaceMajor classesReticulumCompartmentsBiogenesisCommon setCellsHydrolasesPlasmalemmaDigestion processSorting