2019
Sensitive detection of EBV microRNAs across cancer spectrum reveals association with decreased survival in adult acute myelocytic leukemia
Movassagh M, Oduor C, Forconi C, Moormann A, Bailey J. Sensitive detection of EBV microRNAs across cancer spectrum reveals association with decreased survival in adult acute myelocytic leukemia. Scientific Reports 2019, 9: 20321. PMID: 31889055, PMCID: PMC6937232, DOI: 10.1038/s41598-019-56472-1.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusEBV positivityEBV microRNAsAdult acute myeloid leukemia patientsAdult acute myelocytic leukemiaAcute myeloid leukemia patientsIndependent risk factorMyeloid leukemia patientsAcute myelocytic leukemiaPoor patient outcomesSpectrum of cancersMessenger RNAAdult patientsClinical outcomesBarr virusImmune impairmentAML tumorsRisk factorsPatient outcomesLeukemia patientsPediatric AMLMyelocytic leukemiaPrognostic biomarkerCancer spectrumNumerous human cancers
2018
Systematic pan-cancer analysis of somatic allele frequency
Spurr L, Li M, Alomran N, Zhang Q, Restrepo P, Movassagh M, Trenkov C, Tunnessen N, Apanasovich T, Crandall K, Edwards N, Horvath A. Systematic pan-cancer analysis of somatic allele frequency. Scientific Reports 2018, 8: 7735. PMID: 29769535, PMCID: PMC5956099, DOI: 10.1038/s41598-018-25462-0.Peer-Reviewed Original ResearchConceptsTotal gene expressionCancer-implicated genesSomatic allelesGene expressionHigh allele frequencyNonsense-mediated mRNA decayAllele frequenciesSomatic variantsKey cancer genesDNA sequencing dataSingle nucleotide variantsPan-cancer analysisTumor somatic variantsMRNA decayCancer Genome AtlasSequencing dataCGC genesNormal RNACancer genesNucleotide variantsGenesTumor transcriptomeGenetic variantsGenome AtlasImbalanced expression