2013
Is Ki-67 Expression Prognostic for Local Relapse in Early-Stage Breast Cancer Patients Treated With Breast Conservation Therapy (BCT)?
Hafeez F, Neboori HJ, Harigopal M, Wu H, Haffty BG, Yang Q, Schiff D, Moran MS. Is Ki-67 Expression Prognostic for Local Relapse in Early-Stage Breast Cancer Patients Treated With Breast Conservation Therapy (BCT)? International Journal Of Radiation Oncology • Biology • Physics 2013, 87: 344-348. PMID: 23910708, DOI: 10.1016/j.ijrobp.2013.05.052.Peer-Reviewed Original ResearchConceptsBreast conservation therapyEarly-stage breast cancer patientsHuman epidermal growth factor receptor 2Recurrence-free survivalBreast cancer patientsKi-67 expressionKi-67Clinicopathologic featuresConservation therapyCancer patientsIndependent associationLocoregional recurrence-free survivalDistant metastasis-free survivalLocal relapse-free survivalEpidermal growth factor receptor 2Univariate/multivariate analysisPrognostic clinicopathologic featuresCause-specific survivalHormone receptor statusGrowth factor receptor 2Metastasis-free survivalRelapse-free survivalKi-67 overexpressionSignificant independent associationKi-67 staining
2012
Analysis of coronary artery dosimetry in the 3-dimensional era: Implications for organ-at-risk segmentation and dose tolerances in left-sided tangential breast radiation
Evans SB, Panigrahi B, Northrup V, Patterson J, Baldwin DE, Higgins SA, Moran MS. Analysis of coronary artery dosimetry in the 3-dimensional era: Implications for organ-at-risk segmentation and dose tolerances in left-sided tangential breast radiation. Practical Radiation Oncology 2012, 3: e55-e60. PMID: 24674321, DOI: 10.1016/j.prro.2012.06.007.Peer-Reviewed Original ResearchMean LAD doseLAD doseBreast radiationLAD arteryLeft-sided breast cancer patientsLeft main coronary arteryHeart dose constraintsMean heart doseTangential radiation therapyAnterior descending (LAD) arteryMain coronary arteryBreast cancer patientsHeart V10Heart V25Proximal LADHeart doseStudy cohortCoronary arteryCancer patientsMean doseRadiation therapyDose correlatesDose constraintsArteryPercent increaseA Prospective, Multicenter Study of Complementary/Alternative Medicine (CAM) Utilization During Definitive Radiation for Breast Cancer
Moran MS, Ma S, Jagsi R, Yang TJ, Higgins SA, Weidhaas JB, Wilson LD, Lloyd S, Peschel R, Gaudreau B, Rockwell S. A Prospective, Multicenter Study of Complementary/Alternative Medicine (CAM) Utilization During Definitive Radiation for Breast Cancer. International Journal Of Radiation Oncology • Biology • Physics 2012, 85: 40-46. PMID: 22658441, DOI: 10.1016/j.ijrobp.2012.03.025.Peer-Reviewed Original ResearchConceptsBreast cancer patientsAlternative medicine utilizationCancer patientsBreast cancerCAM practicesDefinitive radiationCAM usersMedicine utilizationBreast patientsFirst prospective studyRadiation therapy useMulti-institutional studyOral CAMYounger patientsTherapy useCAM useStudy cohortCAM usageMulticenter studyProspective studyCAM utilizationStage 0Radiation therapyPatientsMultivariate analysis
2010
Evaluation of Vascular Endothelial Growth Factor as a Prognostic Marker for Local Relapse in Early-Stage Breast Cancer Patients Treated With Breast-Conserving Therapy
Moran MS, Yang Q, Goyal S, Harris L, Chung G, Haffty BG. Evaluation of Vascular Endothelial Growth Factor as a Prognostic Marker for Local Relapse in Early-Stage Breast Cancer Patients Treated With Breast-Conserving Therapy. International Journal Of Radiation Oncology • Biology • Physics 2010, 81: 1236-1243. PMID: 21093162, DOI: 10.1016/j.ijrobp.2010.07.031.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnalysis of VarianceBiomarkers, TumorBlack PeopleBreast NeoplasmsDisease-Free SurvivalFemaleFollow-Up StudiesHumansMastectomy, SegmentalMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingPrognosisRadiotherapyTissue Array AnalysisVascular Endothelial Growth Factor AWhite PeopleConceptsEarly-stage breast cancerBreast-conserving therapyLocal relapse-free survivalRelapse-free survivalVascular endothelial growth factorEarly-stage breast cancer patientsLocal relapseBreast cancer patientsBreast cancerEndothelial growth factorVEGF expressionOverall survivalPrognostic valueCancer patientsTissue microarrayEstrogen receptor/progesterone receptor statusDistant metastasis-free survivalNodal relapse-free survivalGrowth factorProgesterone receptor statusInstitutional review board approvalMetastasis-free survivalLong-term outcomesMargin-negative patientsOverexpression of VEGF
2009
Does Compliance with Radiation Therapy Differ in African‐American Patients with Early‐Stage Breast Cancer?1
Sharma C, Harris L, Haffty BG, Yang Q, Moran MS. Does Compliance with Radiation Therapy Differ in African‐American Patients with Early‐Stage Breast Cancer?1. The Breast Journal 2009, 16: 193-196. PMID: 20030649, DOI: 10.1111/j.1524-4741.2009.00874.x.Peer-Reviewed Original ResearchConceptsBreast conservation therapyAA patientsWhite patientsWorse outcomesRadiation therapyAfrican American breast cancer patientsEarly-stage breast cancerAdjuvant chemotherapy regimensMedian radiation doseBreast cancer patientsLarge institutional seriesAfrican American patientsDate of treatmentChemotherapy regimenChemotherapy regimensSame radiation dosesChart reviewInstitutional seriesTherapy differsTreatment breaksConservation therapyCancer patientsBreast cancerMedian numberTreatment daysEvaluation of Single Nucleotide Polymorphisms (SNP) in the P53 Binding Protein Gene (TP53BP1), in Breast Cancer Patients Treated with Breast Conserving Surgery and Whole-breast Irradiation (BCS+RT)
Haffty B, Goyal S, Green C, Schiff D, Yang Q, Moran M, Kulkarni D, Ganesan S, Hirshfield K. Evaluation of Single Nucleotide Polymorphisms (SNP) in the P53 Binding Protein Gene (TP53BP1), in Breast Cancer Patients Treated with Breast Conserving Surgery and Whole-breast Irradiation (BCS+RT). International Journal Of Radiation Oncology • Biology • Physics 2009, 75: s6. DOI: 10.1016/j.ijrobp.2009.07.040.Peer-Reviewed Original ResearchVascular Endothelial Growth Factor as a Prognostic Marker for Local Relapse in Early-stage Breast Cancer Patients Treated with Breast Conservation Therapy
Moran M, Yang Q, Goyal S, Haffty B. Vascular Endothelial Growth Factor as a Prognostic Marker for Local Relapse in Early-stage Breast Cancer Patients Treated with Breast Conservation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2009, 75: s7-s8. DOI: 10.1016/j.ijrobp.2009.07.043.Peer-Reviewed Original Research
2008
Prognostic Implications of Mammographically Occult, Early Stage Breast Cancer Patients Treated with Breast Conservation Therapy
Yang T, Yang Q, Haffty B, Moran M. Prognostic Implications of Mammographically Occult, Early Stage Breast Cancer Patients Treated with Breast Conservation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2008, 72: s92. DOI: 10.1016/j.ijrobp.2008.06.976.Peer-Reviewed Original Research
1998
Lobular carcinoma in situ as a component of breast cancer: The long-term outcome in patients treated with breast-conservation therapy
Moran M, Haffty B. Lobular carcinoma in situ as a component of breast cancer: The long-term outcome in patients treated with breast-conservation therapy. International Journal Of Radiation Oncology • Biology • Physics 1998, 40: 353-358. PMID: 9457821, DOI: 10.1016/s0360-3016(97)00573-7.Peer-Reviewed Original ResearchConceptsPercentage of patientsBreast cancer patientsLong-term outcomesConservative surgeryControl groupRadiation therapyHistologic componentsPrimary histologyLobular carcinomaCancer patientsBreast cancerComparable local control ratesDistant disease-free survivalTumor recurrence-free survivalDisease-free survivalLocal control rateRecurrence-free survivalAge of presentationBreast conservation therapyEstrogen receptor statusSignificant differencesReexcision specimenResidual LCISAdjuvant therapyBilateral disease