Diabetes prevention in the Caribbean using Lifestyle Intervention and Metformin Escalation (LIME): Protocol for a hybrid Type-1 effectiveness-implementation trial using a quasi-experimental study design
Hassan S, Sobers N, Paul-Charles J, Herbert J, Dharamraj K, Cruz E, Garcia E, Fredericks L, Desai MM, Roy S, Williams S, Linnander E, Crusto C, Horowitz CR, Arniella G, Cattamanchi A, Adams OP, Nunez-Smith M. Diabetes prevention in the Caribbean using Lifestyle Intervention and Metformin Escalation (LIME): Protocol for a hybrid Type-1 effectiveness-implementation trial using a quasi-experimental study design. Contemporary Clinical Trials Communications 2021, 22: 100750. PMID: 33997458, PMCID: PMC8095103, DOI: 10.1016/j.conctc.2021.100750.Peer-Reviewed Original ResearchDiabetes prevention interventionPrevention interventionsLifestyle interventionHybrid type 1 effectiveness-implementation trialPrimary effectiveness outcomeIncidence of diabetesEffectiveness-implementation trialType 2 diabetesHigh-risk individualsQuasi-experimental study designMetformin medicationMetformin prescribingIntervention armEligible participantsLifestyle changesProportion of individualsEffectiveness outcomesQuasi-experimental studyClinical sitesPrediabetesClinical settingStudy designInterventionDiabetesIndividuals