2022
Benefits and harms of oral anticoagulants for atrial fibrillation in nursing home residents with advanced dementia
Ouellet GM, O'Leary JR, Leggett CG, Skinner J, Tinetti ME, Cohen AB. Benefits and harms of oral anticoagulants for atrial fibrillation in nursing home residents with advanced dementia. Journal Of The American Geriatrics Society 2022, 71: 561-568. PMID: 36310367, PMCID: PMC9957933, DOI: 10.1111/jgs.18108.Peer-Reviewed Original ResearchConceptsNursing home residentsAtrial fibrillationAdvanced dementiaHome residentsStroke riskLong-stay nursing home residentsMedicare Part D claimsDementia-related mortalityGuideline-recommended thresholdHarms of anticoagulationRetrospective cohort studyMultivariable survival analysisValvular heart diseaseRisk of deathPart D claimsMonths of lifeMinimum Data SetAnticoagulant discontinuationAnticoagulated individualsMean CHAVASc scoreCause mortalityMultivariable adjustmentOral anticoagulantsCohort study
2019
IMPLEMENTATION OF PATIENT PRIORITIES CARE WITHIN A VA GERIATRICS CLINIC
Freytag J, Dindo L, Catic A, Naik A, Tinetti M. IMPLEMENTATION OF PATIENT PRIORITIES CARE WITHIN A VA GERIATRICS CLINIC. Innovation In Aging 2019, 3: s774-s774. PMCID: PMC6846413, DOI: 10.1093/geroni/igz038.2844.Peer-Reviewed Original ResearchPatient Priorities CareMultiple chronic conditionsGeriatric clinicPatient prioritiesUsual careOlder adultsSingle disease guidelinesRetrospective cohort studySelf-care recommendationsMore recommendationsUC patientsCohort studyPrimary clinicianChronic conditionsMedical recordsMultimorbid adultsSame clinicianCare workflowClinicCliniciansPatientsWay cliniciansCareMedicationsPriority care
2015
Association between guideline recommended drugs and death in older adults with multiple chronic conditions: population based cohort study
Tinetti ME, McAvay G, Trentalange M, Cohen AB, Allore HG. Association between guideline recommended drugs and death in older adults with multiple chronic conditions: population based cohort study. The BMJ 2015, 351: h4984. PMID: 26432468, PMCID: PMC4591503, DOI: 10.1136/bmj.h4984.Peer-Reviewed Original ResearchConceptsSerotonin-norepinephrine reuptake inhibitorsMultiple chronic conditionsSelective serotonin reuptake inhibitorsAdjusted hazard ratioRisk of deathCalcium channel blockersChronic conditionsHazard ratioΒ-blockersCohort studyReuptake inhibitorsAtrial fibrillationOlder adultsChannel blockersCardiovascular drugsSSRIs/serotonin-norepinephrine reuptake inhibitorsRenin-angiotensin system blockersNorepinephrine reuptake inhibitorsSerotonin reuptake inhibitorsCommon combinationRAS blockersSystem blockersStudy drugHeart failureThromboembolic disease
2009
Clinical Features to Identify Urinary Tract Infection in Nursing Home Residents: A Cohort Study
Juthani‐Mehta M, Quagliarello V, Perrelli E, Towle V, Van Ness PH, Tinetti M. Clinical Features to Identify Urinary Tract Infection in Nursing Home Residents: A Cohort Study. Journal Of The American Geriatrics Society 2009, 57: 963-970. PMID: 19490243, PMCID: PMC2692075, DOI: 10.1111/j.1532-5415.2009.02227.x.Peer-Reviewed Original ResearchConceptsUrinary tract infectionNursing home residentsClinical featuresHome residentsCohort studyTract infectionsMental statusPresence of dysuriaObservational cohort studyArea nursing homesUrine culturePyuriaClinical definitionBacteriuriaHigh riskLower riskDiagnostic uncertaintyNursing homesCombined outcomeDysuriaInfectionUrineOutcomesEpisodesRisk
2007
Diagnostic Accuracy of Criteria for Urinary Tract Infection in a Cohort of Nursing Home Residents*
Juthani‐Mehta M, Tinetti M, Perrelli E, Towle V, Van Ness PH, Quagliarello V. Diagnostic Accuracy of Criteria for Urinary Tract Infection in a Cohort of Nursing Home Residents*. Journal Of The American Geriatrics Society 2007, 55: 1072-1077. PMID: 17608881, DOI: 10.1111/j.1532-5415.2007.01217.x.Peer-Reviewed Original ResearchConceptsUrinary tract infectionNursing home residentsNegative predictive valuePositive predictive valueConsensus-based criteriaLaboratory evidenceHome residentsTract infectionsPredictive valueEvidence-based clinical criteriaDiagnostic accuracyProspective cohort studySimilar test characteristicsMcGeer criteriaUTI criteriaCohort studyProspective surveillanceUrine cultureClinical criteriaNursing homesTest characteristicsInfectionLoeb criteriaParticipantsSpecificity
2000
Environmental Hazards and the Risk of Nonsyncopal Falls in the Homes of Community-Living Older Persons
Gill T, Williams C, Tinetti M. Environmental Hazards and the Risk of Nonsyncopal Falls in the Homes of Community-Living Older Persons. Medical Care 2000, 38: 1174-1183. PMID: 11186296, DOI: 10.1097/00005650-200012000-00004.Peer-Reviewed Original ResearchConceptsNonsyncopal fallsOlder personsCommunity-living older personsProspective cohort studyBalance/gaitYears of ageFall calendarsCohort studyResearch nursesRoom assessmentFall preventionRelative riskSlip hazardsConsistent associationNumber of participantsRiskFace validityPhone callsHigh face validityProbability sampleAgeAssociationFallYearsStandard instrumentsHealth, Functional, and Psychological Outcomes Among Older Persons with Chronic Dizziness
Tinetti M, Williams C, Gill T. Health, Functional, and Psychological Outcomes Among Older Persons with Chronic Dizziness. Journal Of The American Geriatrics Society 2000, 48: 417-421. PMID: 10798469, DOI: 10.1111/j.1532-5415.2000.tb04700.x.Peer-Reviewed Original ResearchConceptsSelf-rated healthChronic dizzinessDepressive symptomsInstrumental activitiesDaily livingOlder personsProspective cohort studyGoals of carePotential confounding factorsCohort studyAdverse outcomesDizzinessAge 72Clinical strategiesBaseline levelsConfounding factorsSocial disabilityDiscrete diseaseSymptomsHealth conditionsMarginal significanceHospitalizationSyncopeOutcomesPsychological outcomes
1999
The Combined Effects of Baseline Vulnerability and Acute Hospital Events on the Development of Functional Dependence Among Community-Living Older Persons
Gill T, Williams C, Tinetti M. The Combined Effects of Baseline Vulnerability and Acute Hospital Events on the Development of Functional Dependence Among Community-Living Older Persons. The Journals Of Gerontology Series A 1999, 54: m377-m383. PMID: 10462171, DOI: 10.1093/gerona/54.7.m377.Peer-Reviewed Original ResearchConceptsCommunity-living older personsValidation cohortDevelopment cohortOlder personsBaseline vulnerabilityHospital eventsPopulation-based cohort studyAcute care hospital admissionsCommunity-living personsHigh-risk groupSkilled nursing facilitiesYears of ageCohort studyHospital admissionPrimary outcomeComparable personsNew disabilityDaily livingNursing facilitiesCohortCognitive statusHigh-vulnerability groupPrecipitating eventsPhysical performanceAdmissionWho Dies at Home? Determinants of Site of Death for Community‐Based Long‐Term Care Patients
Fried T, Pollack D, Drickamer M, Tinetti M. Who Dies at Home? Determinants of Site of Death for Community‐Based Long‐Term Care Patients. Journal Of The American Geriatrics Society 1999, 47: 25-29. PMID: 9920226, DOI: 10.1111/j.1532-5415.1999.tb01897.x.Peer-Reviewed Original ResearchConceptsSite of deathInpatient hospiceLong-term care patientsCommunity-based long-term care programsDependent functional statusPatients 65 yearsChronic lung diseaseCoronary artery diseaseYear of admissionCommunity-based long-term careLong-term care programsLong-term careCohort studyArtery diseaseCare patientsHome deathLung diseaseFunctional statusPatient preferencesHomecare patientsFemale genderTerminal careMAIN OUTCOMECare needsNursing homes
1998
Development of a Test Battery to Identify Older Drivers at Risk for Self‐Reported Adverse Driving Events
Marottoli R, Richardson E, Stowe M, Miller E, Brass L, Cooney L, Tinetti M. Development of a Test Battery to Identify Older Drivers at Risk for Self‐Reported Adverse Driving Events. Journal Of The American Geriatrics Society 1998, 46: 562-568. PMID: 9588368, DOI: 10.1111/j.1532-5415.1998.tb01071.x.Peer-Reviewed Original ResearchConceptsAdverse driving eventsFunctional abilityTest batteryLimited neck rotationSafety cohortAdverse eventsCohort studyVisual acuityNumber cancellation taskOutcome measuresNeck rotationMean periodParticipants' homesOlder personsClinician's officeParticipants' historySafety interviewsCohortBattery of testsPossible interventionsEtiology of impairmentsProbability sampleImpairmentOlder driversCharacteristic analysisFactors Associated With Six‐Month Mortality in Recipients of Community‐Based Long‐Term Care
Fried T, Pollack D, Tinetti M. Factors Associated With Six‐Month Mortality in Recipients of Community‐Based Long‐Term Care. Journal Of The American Geriatrics Society 1998, 46: 193-197. PMID: 9475448, DOI: 10.1111/j.1532-5415.1998.tb02538.x.Peer-Reviewed Original ResearchConceptsSix-month mortalityShort-term mortalityPresence of cancerCommunity-based long-term careLong-term careHeart diseaseChronic obstructive pulmonary diseaseNutritional problemsObstructive pulmonary diseaseSevere cognitive impairmentCommunity-based waiverCohort studyPulmonary diseaseHomecare programMortality registryMale sexFunctional impairmentClinical dataAdmission assessmentRoutine assessmentCognitive impairmentHealth statusMultivariate analysisCognitive statusMortality
1997
Predictors of Recovery in Activities of Daily Living Among Disabled Older Persons Living in the Community
Gill T, Robison J, Tinetti M. Predictors of Recovery in Activities of Daily Living Among Disabled Older Persons Living in the Community. Journal Of General Internal Medicine 1997, 12: 757-762. PMID: 9436895, PMCID: PMC1497202, DOI: 10.1046/j.1525-1497.1997.07161.x.Peer-Reviewed Original ResearchConceptsGood nutritional statusADL functionDisabled older personsNutritional statusADL recoveryDaily livingFolstein Mini-Mental State Examination (MMSE) scoresOlder personsMini-Mental State Examination scoreMarkers of resiliencyProspective cohort studyPredictors of recoveryState Examination scoreIntact cognitive functionCohort studyMultivariable analysisMore ADLsMMSE scoresSelf-efficacy scoresHome assessmentBivariate analysisCognitive functionGeneral communityPhysical performanceADLA Predictive Model for ADL Dependence in Community‐Living Older Adults Based on a Reduced Set of Cognitive Status Items
Gill T, Williams C, Richardson E, Berkman L, Tinetti M. A Predictive Model for ADL Dependence in Community‐Living Older Adults Based on a Reduced Set of Cognitive Status Items. Journal Of The American Geriatrics Society 1997, 45: 441-445. PMID: 9100712, DOI: 10.1111/j.1532-5415.1997.tb05168.x.Peer-Reviewed Original ResearchConceptsADL dependenceDevelopment cohortValidation cohortPresence of impairmentsPopulation-based cohort studyMini-Mental State Examination (MMSE) itemCommunity-living older adultsCommunity-living personsSelf-reported ADLOlder person's riskYears of ageCohort studyResearch nursesMultivariable analysisRisk groupsBaseline interviewInitial cohortStratified subjectsSeparate cohortCohortPerson's riskGeneral communityOlder adultsCognitive AssessmentComparable subjectsDriving Cessation and Increased Depressive Symptoms: Prospective Evidence from the New Haven EPESE
Marottoli R, de Leon C, Glass T, Williams C, Cooney L, Berkman L, Tinetti M. Driving Cessation and Increased Depressive Symptoms: Prospective Evidence from the New Haven EPESE. Journal Of The American Geriatrics Society 1997, 45: 202-206. PMID: 9033520, DOI: 10.1111/j.1532-5415.1997.tb04508.x.Peer-Reviewed Original ResearchConceptsHealth-related factorsDepressive symptomsEpidemiologic Studies Depression ScaleEffect of cessationCohort studyMultivariable analysisOlder driversProspective evidenceElderly cohortEpidemiologic studiesMedical conditionsPotential confoundingAlternative transportation strategiesSymptomsCessationStrongest predictorNew HavenUrban communitiesFactorsCohortEPESEActive drivers
1995
The Contribution of Predisposing and Situational Risk Factors to Serious Fall Injuries
Tinetti M, Doucette J, Claus E. The Contribution of Predisposing and Situational Risk Factors to Serious Fall Injuries. Journal Of The American Geriatrics Society 1995, 43: 1207-1213. PMID: 7594153, DOI: 10.1111/j.1532-5415.1995.tb07395.x.Peer-Reviewed Original ResearchConceptsSerious fall injuriesRisk factorsFall injuriesSerious injuriesSituational risk factorsLower body mass indexPercentage of fallersBody mass indexLoss of consciousnessMulticomponent intervention programPhysical performance measuresFirst fallRisk of injuryCohort studyInjury overallPrimary outcomeMass indexHead injuryJoint dislocationFemale genderHome assessmentCognitive impairmentPreventive programsMultivariate analysisInjury
1993
A predictive index for functional decline in hospitalized elderly medical patients
Inouye S, Wagner D, Acampora D, Horwitz R, Cooney L, Hurst L, Tinetti M. A predictive index for functional decline in hospitalized elderly medical patients. Journal Of General Internal Medicine 1993, 8: 645-652. PMID: 8120679, DOI: 10.1007/bf02598279.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAged, 80 and overChi-Square DistributionCohort StudiesConnecticutFemaleGeriatric AssessmentHospital Bed Capacity, 500 and overHospitals, UniversityHumansLikelihood FunctionsMaleMultivariate AnalysisPrevalenceProportional Hazards ModelsProspective StudiesReproducibility of ResultsRisk FactorsSingle-Blind MethodConceptsFunctional declineRisk factorsMedical patientsValidation cohortDevelopment cohortHospitalized elderly medical patientsIndependent baseline risk factorsLow social activity levelNumber of RFsPredictive indexBaseline risk factorsGeneral medical wardsProspective cohort studyGeneral medical patientsHigh-risk groupUniversity Teaching HospitalElderly medical patientsRisk stratification systemNursing home placementRate of deathSocial activity levelsComparable patientsCohort studyElderly patientsMedical wards