2022
Drug-Induced Acute Kidney Injury
Perazella MA, Rosner MH. Drug-Induced Acute Kidney Injury. Clinical Journal Of The American Society Of Nephrology 2022, 17: 1220-1233. PMID: 35273009, PMCID: PMC9435983, DOI: 10.2215/cjn.11290821.Peer-Reviewed Original ResearchConceptsKidney injuryTubular injuryDrug-induced acute kidney injuryT cell-mediated immune responsesDrug-related kidney injuryCell-mediated immune responsesAcute interstitial nephritisDirect tubular injuryTreatment of AKIAcute kidney injuryAcute tubular injuryIntensive care unitInduction of inflammationAKI riskIntratubular obstructionTubulointerstitial injuryInterstitial nephritisCare unitInflammation leadInjury resultsCommon causeImmune responseHospital wardsProximal tubulesAKIUrine testing to differentiate glomerular from tubulointerstitial diseases on kidney biopsy
Tran AC, Melchinger H, Weinstein J, Shaw M, Kent C, Perazella MA, Wilson FP, Parikh CR, Moledina DG. Urine testing to differentiate glomerular from tubulointerstitial diseases on kidney biopsy. Practical Laboratory Medicine 2022, 30: e00271. PMID: 35465621, PMCID: PMC9018443, DOI: 10.1016/j.plabm.2022.e00271.Peer-Reviewed Original ResearchTubulointerstitial diseaseKidney biopsyGlomerular diseaseUrine albuminHistological diagnosisUrine uromodulinUrine testsHigher urine albuminUrine sediment microscopyCohort of participantsDipstick hematuriaTubular injuryAppropriate patientsUrine testingMultivariable modelHigher oddsBiopsyClinical decisionSediment microscopyDiseasePatientsHealth biomarkersUrine samplesDiagnosisCohort
2018
Cancer drugs and the glomerulus
Shah H, Uppal N, Perazella M. Cancer drugs and the glomerulus. Journal Of Onco-Nephrology 2018, 2: 78-91. DOI: 10.1177/2399369318815418.Peer-Reviewed Original ResearchGlomerular lesionsCancer drugsAnti-vascular endothelial growth factor inhibitorsPoor renal outcomeAcute interstitial nephritisAcute kidney injuryAcute tubular necrosisGrowth factor inhibitorsMinimal change diseaseFocal segmental glomerulosclerosisTyrosine kinase inhibitorsNovel cancer drugsRenal outcomesKidney injuryThrombotic microangiopathyNovel immunotherapiesTubular injuryTubular necrosisInterstitial nephritisGlomerular toxicityChange diseaseFactor inhibitorsSegmental glomerulosclerosisGlomerular diseasePodocyte injury
2017
AKI in Multiple Myeloma: Paraproteins, Metabolic Disturbances, and Drug Toxicity
Shah M, Perazella M. AKI in Multiple Myeloma: Paraproteins, Metabolic Disturbances, and Drug Toxicity. Journal Of Onco-Nephrology 2017, 1: 188-197. DOI: 10.5301/jo-n.5000030.Peer-Reviewed Original ResearchAcute kidney injuryMultiple myelomaMyeloma patientsMetabolic disturbancesPresence of AKIDrug-related nephrotoxicityFull renal recoveryProximal tubular injuryTumor lysis syndromeLight chain levelsHigh-cutoff hemodialysisB cell clonesMyeloma managementNephrotoxin exposureRenal recoveryInitial manifestationKidney injuryLysis syndromePrerenal azotemiaFrequent complicationTubular injuryKidney biopsyPlasma exchangeVolume statusExtracorporeal therapyUpdate on the Renal Effects of Anticancer Agents
Perazella M. Update on the Renal Effects of Anticancer Agents. Journal Of Onco-Nephrology 2017, 1: 170-178. DOI: 10.5301/jo-n.5000026.Peer-Reviewed Original ResearchAnticancer drug nephrotoxicityChronic kidney injuryKidney injuryDrug nephrotoxicityAcute interstitial nephritisAcute kidney injuryAcute tubular injuryNumber of drugsNumber of lesionsAcid-base disturbancesNephrology updateRenal effectsNovel immunotherapiesTubular injuryInterstitial nephritisGlomerular injuryKidney diseaseCancer patientsConventional chemotherapyRenal metabolismSystemic toxicityInjuryNephrotoxicityChemotherapeutic drugsPatients
2009
Acute phosphate nephropathy
Markowitz GS, Perazella MA. Acute phosphate nephropathy. Kidney International 2009, 76: 1027-1034. PMID: 19675530, DOI: 10.1038/ki.2009.308.Peer-Reviewed Original ResearchConceptsAcute phosphate nephropathyAcute kidney injuryChronic kidney diseasePhosphate nephropathySubsequent chronic renal failureChronic tubular injuryAngiotensin receptor blockersChronic renal failureHigh-risk patientsRenal biopsy findingsClinical-pathological entityAggressive hydrationKidney injuryReceptor blockersBiopsy findingsRenal failureTubular injuryKidney diseasePathological entityRisk factorsFemale genderDistal tubulesEpidemiologic studiesDistal nephronEnzyme inhibitors
1993
Renal Failure and Severe Hypokalemia Associated With Acute Myelomonocytic Leukemia
Perazella M, Eisen R, Frederick W, Brown E. Renal Failure and Severe Hypokalemia Associated With Acute Myelomonocytic Leukemia. American Journal Of Kidney Diseases 1993, 22: 462-467. PMID: 8372846, DOI: 10.1016/s0272-6386(12)70154-3.Peer-Reviewed Original ResearchConceptsAcute myelomonocytic leukemiaRenal failureMyelomonocytic leukemiaRenal parenchymal infiltrationRenal tubular injuryHypokalemia AssociatedInappropriate kaliuresisMicrovascular insufficiencyRenal insufficiencySevere hypokalemiaTubular injuryParenchymal infiltrationSetting of leukemiaBlast cellsLeukemiaMetabolic perturbationsHypokalemiaVariety of mechanismsInsufficiencyFailureLeukostasisKaliuresisEtiologyInjury