2000
Trimethoprim-Induced Hyperkalaemia
Perazella M. Trimethoprim-Induced Hyperkalaemia. Drug Safety 2000, 22: 227-236. PMID: 10738846, DOI: 10.2165/00002018-200022030-00006.Peer-Reviewed Original ResearchConceptsRenal potassium excretionPotassium excretionHigh urinary flow ratesPotassium homeostasisManagement of hyperkalaemiaGlomerular filtration ratePotassium-sparing diuretic amilorideUrinary flow rateRecognition of patientsDistal nephron cellsTrimethoprim therapyRenal impairmentCommon complicationLoop diureticsEpithelial sodium channelIntravenous fluidsVolume repletionAdverse reactionsFiltration rateRisk factorsStandard dosageAntikaliuretic effectHyperkalaemiaIsotonic fluidsDistal nephron
1998
Midodrine is effective and safe therapy for intradialytic hypotension over 8 months of follow-up.
Cruz D, Mahnensmith R, Brickel H, Perazella M. Midodrine is effective and safe therapy for intradialytic hypotension over 8 months of follow-up. Clinical Nephrology 1998, 50: 101-7. PMID: 9725781.Peer-Reviewed Original ResearchConceptsSymptomatic intradialytic hypotensionIntradialytic hypotensionMidodrine therapyHD sessionSafe therapyEnd-stage renal disease patientsStage renal disease patientsAlpha-1 adrenergic agonistMean ultrafiltration volumeSignificant causative roleRenal disease patientsTreatment-related factorsPatient-specific factorsMost therapeutic interventionsKt/VHypotensive symptomsBlood pressureHemodialysis patientsHD patientsDisease patientsSubjective improvementAdverse reactionsFrustrating complicationMean albuminSafe treatment
1996
Trimethoprim-sulfamethoxazole: hyperkalemia is an important complication regardless of dose.
Perazella M, Mahnensmith R. Trimethoprim-sulfamethoxazole: hyperkalemia is an important complication regardless of dose. Clinical Nephrology 1996, 46: 187-92. PMID: 8879854.Peer-Reviewed Original ResearchConceptsTrimethoprim-sulfamethoxazole therapyStandard doseDevelopment of hyperkalemiaTrimethoprim-sulfamethoxazole useMild renal insufficiencyProspective surveillance studyPotassium-sparing diuretic amilorideRenal potassium excretionPneumocystis carinii pneumoniaLethal adverse reactionHandful of casesRenal insufficiencyElderly patientsPotassium excretionSevere hyperkalemiaImportant complicationAIDS patientsCarinii pneumoniaTrimethoprim-sulfamethoxazoleAdverse reactionsInduced hyperkalemiaPotassium disordersHyperkalemiaSurveillance studyPatients