2015
Contact Dermatitis
Rozenblit M, Guttman‐Yassky E. Contact Dermatitis. 2015, 25-35. DOI: 10.1002/9781118609125.ch3.Peer-Reviewed Original ResearchIrritant contact dermatitisAllergic contact dermatitisContact dermatitisType IV hypersensitivity reactionHypersensitivity reactionsPhysical examinationPatch testingInflammatory reactionDermatitisCommon agentsGlucocorticoid creamWet dressingsSkinDiagnosisTreatmentIndustrial solventsAgentsLichenificationPatientsPrognosisAllergensHyperkeratosesPreventionPatients with atopic dermatitis have attenuated and distinct contact hypersensitivity responses to common allergens in skin
da Rosa J, Malajian D, Shemer A, Rozenblit M, Dhingra N, Czarnowicki T, Khattri S, Ungar B, Finney R, Xu H, Zheng X, Estrada YD, Peng X, Suárez-Fariñas M, Krueger JG, Guttman-Yassky E. Patients with atopic dermatitis have attenuated and distinct contact hypersensitivity responses to common allergens in skin. Journal Of Allergy And Clinical Immunology 2015, 135: 712-720. PMID: 25583101, DOI: 10.1016/j.jaci.2014.11.017.Peer-Reviewed Original ResearchConceptsAtopic dermatitisAllergic contact dermatitis reactionsBackground Atopic dermatitisContact hypersensitivity responseTh17/ILCommon contact allergensNon-AD groupAllergic immune reactionsAllergic contact dermatitisCommon inflammatory diseaseTissue immune responseContact dermatitis reactionsTh1 productsTh2 productsAllergen challengeImmune abnormalitiesAllergic sensitizationCommon allergensTh1 subsetContact sensitizationHypersensitivity responseInflammatory productsBiopsy specimensInflammatory diseasesContact allergens
2014
Molecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response
Dhingra N, Shemer A, da Rosa J, Rozenblit M, Fuentes-Duculan J, Gittler JK, Finney R, Czarnowicki T, Zheng X, Xu H, Estrada YD, Cardinale I, Suárez-Fariñas M, Krueger JG, Guttman-Yassky E. Molecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response. Journal Of Allergy And Clinical Immunology 2014, 134: 362-372. PMID: 24768652, DOI: 10.1016/j.jaci.2014.03.009.Peer-Reviewed Original ResearchConceptsAllergic contact dermatitisHuman allergic contact dermatitisTh1/Th17Different allergensHigher immune activationMurine contact hypersensitivityStrong Th2 biasContact hypersensitivity modelCommon occupational diseaseT cell activationTh22 polarizationCommon allergensContact hypersensitivityTh2 biasDermatitis skinImmune activationClinical reactionsHypersensitivity modelImmune polarizationIndividual allergensContact dermatitisImmune responseAllergen groupsInnate immunityOccupational diseases