2019
Nicotinic Acetylcholine Receptor Signaling in the Hypothalamus: Mechanisms Related to Nicotine’s Effects on Food Intake
Calarco CA, Picciotto MR. Nicotinic Acetylcholine Receptor Signaling in the Hypothalamus: Mechanisms Related to Nicotine’s Effects on Food Intake. Nicotine & Tobacco Research 2019, 22: 152-163. PMID: 30690485, PMCID: PMC7297099, DOI: 10.1093/ntr/ntz010.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsFood intakeNicotinic acetylcholine receptorsWeight gainBody weightPreclinical workAcetylcholine receptorsPost-cessation weight gainOrexigenic agouti-related peptideAnorexigenic proopiomelanocortin (POMC) neuronsNicotine replacement therapyAgouti-related peptideNicotinic agonist cytisineAbility of nicotineLower body weightProopiomelanocortin neuronsNicotine administrationHypothalamic circuitsReplacement therapyArcuate nucleusNicotine effectsNicotine actsAgonist cytisineAverage weight gainTobacco useRodent models
2017
Access to nicotine in drinking water reduces weight gain without changing caloric intake on high fat diet in male C57BL/6J mice
Calarco CA, Lee S, Picciotto MR. Access to nicotine in drinking water reduces weight gain without changing caloric intake on high fat diet in male C57BL/6J mice. Neuropharmacology 2017, 123: 210-220. PMID: 28623168, PMCID: PMC5544033, DOI: 10.1016/j.neuropharm.2017.06.012.Peer-Reviewed Original ResearchConceptsHigh-fat dietCaloric intakeWeight gainFat dietFemale miceMale miceBody weightAdipose tissueEffects of HFDOverall caloric intakeAmphetamine-regulated transcriptNicotinic acetylcholine receptor subunitsLower body weightMelanin-concentrating hormoneSex-dependent mannerRegulation of agoutiChow-fed animalsAcetylcholine receptor subunitsNicotine administrationChronic consumptionArcuate nucleusNicotine dosesNicotine intakeFood intakeTobacco use
2012
Nicotinic Regulation of Energy Homeostasis
Zoli M, Picciotto MR. Nicotinic Regulation of Energy Homeostasis. Nicotine & Tobacco Research 2012, 14: 1270-1290. PMID: 22990212, PMCID: PMC3611985, DOI: 10.1093/ntr/nts159.Peer-Reviewed Original ResearchConceptsEnergy homeostasisCellular targetsPossible molecular targetsPrimary psychoactive substanceCell typesNicotinic acetylcholine receptor subtypesEnergy metabolismAcetylcholine receptor subtypesAbility of nicotineEffects of nicotineRegulation of feedingMolecular targetsFunctional featuresRegulationNicotinic regulationHomeostasisReceptor subtypesNAChR subtypesTobacco smokeBody weightNeuroendocrine systemRecent studiesNicotineMetabolismMammals
2011
Nicotine Decreases Food Intake Through Activation of POMC Neurons
Mineur YS, Abizaid A, Rao Y, Salas R, DiLeone RJ, Gündisch D, Diano S, De Biasi M, Horvath TL, Gao XB, Picciotto MR. Nicotine Decreases Food Intake Through Activation of POMC Neurons. Science 2011, 332: 1330-1332. PMID: 21659607, PMCID: PMC3113664, DOI: 10.1126/science.1201889.Peer-Reviewed Original ResearchConceptsFood intakePOMC neuronsNicotine decreases food intakeDecrease food intakePro-opiomelanocortin (POMC) neuronsΑ3β4 nicotinic acetylcholine receptorsHypothalamic melanocortin systemNicotine-induced decreasesMelanocortin-4 receptorNicotinic acetylcholine receptorsAnorexic effectDecrease appetiteSmoking cessationSynaptic mechanismsMelanocortin systemNovel treatmentsBody weightAcetylcholine receptorsNeurobiological mechanismsNeuronsIntakeSubsequent activationAppetiteActivationReceptors
2006
Nicotine withdrawal increases body weight, neuropeptide Y and Agouti-related protein expression in the hypothalamus and decreases uncoupling protein-3 expression in the brown adipose tissue in high-fat fed mice
Fornari A, Pedrazzi P, Lippi G, Picciotto MR, Zoli M, Zini I. Nicotine withdrawal increases body weight, neuropeptide Y and Agouti-related protein expression in the hypothalamus and decreases uncoupling protein-3 expression in the brown adipose tissue in high-fat fed mice. Neuroscience Letters 2006, 411: 72-76. PMID: 17052838, DOI: 10.1016/j.neulet.2006.10.014.Peer-Reviewed Original ResearchMeSH KeywordsAdipose Tissue, BrownAgouti Signaling ProteinAgouti-Related ProteinAnalysis of VarianceAnimalsBody WeightDietary FatsHypothalamusIntercellular Signaling Peptides and ProteinsIon ChannelsMaleMiceMice, Inbred C57BLMitochondrial ProteinsNeuropeptide YNicotineNicotinic AgonistsReceptors, Adrenergic, betaSubstance Withdrawal SyndromeUncoupling Protein 3ConceptsNicotine withdrawalBrown adipose tissueBody weightNeuropeptide YAdipose tissueOrexigenic peptides neuropeptide YHigh-fat fed miceChronic nicotine treatmentPeptides neuropeptide YHigh-fat dietAbility of nicotineBody weight regulationProtein 3 expressionAnorectic effectNicotine treatmentSmoking cessationFat dietFed miceHuman smokersNormal rodentsWeight regulationIncreased expressionProtein 3Protein expressionExposure results