Lessons learned about [F-18]-AV-1451 off-target binding from an autopsy-confirmed Parkinson’s case
Marquié M, Verwer E, Meltzer A, Kim S, Agüero C, Gonzalez J, Makaretz S, Siao Tick Chong M, Ramanan P, Amaral A, Normandin M, Vanderburg C, Gomperts S, Johnson K, Frosch M, Gómez-Isla T. Lessons learned about [F-18]-AV-1451 off-target binding from an autopsy-confirmed Parkinson’s case. Acta Neuropathologica Communications 2017, 5: 75. PMID: 29047416, PMCID: PMC5648451, DOI: 10.1186/s40478-017-0482-0.Peer-Reviewed Original ResearchConceptsPositron emission tomographyBasal gangliaBinding to neuromelaninPositron emission tomography studiesDementia of AD typeInferior temporal cortexParkinson's diseaseTau pathologyPositron emission tomography scanAlzheimer's diseaseMild cognitive impairmentTemporal cortexAutoradiographic bindingBrain regionsNeurofibrillary tau pathologyOccipital cortexPositron emission tomography signalCognitive impairmentPostmortem materialEntorhinal cortexSubstantia nigraParenchymal hemorrhagePD diagnosisAutoradiography experimentsChoroid plexusPseudoreference Regions for Glial Imaging with 11C-PBR28: Investigation in 2 Clinical Cohorts
Albrecht D, Normandin M, Shcherbinin S, Wooten D, Schwarz A, Zürcher N, Barth V, Guehl N, Akeju O, Atassi N, Veronese M, Turkheimer F, Hooker J, Loggia M. Pseudoreference Regions for Glial Imaging with 11C-PBR28: Investigation in 2 Clinical Cohorts. Journal Of Nuclear Medicine 2017, 59: 107-114. PMID: 28818984, PMCID: PMC5750517, DOI: 10.2967/jnumed.116.178335.Peer-Reviewed Original ResearchConceptsChronic low back painPseudoreference regionGroup differencesDistribution volume ratioOccipital cortexArterial input functionChronic low back pain patientsAbsence of group differencesNo significant group differencesTranslocator protein imagingLow back painRegional group differencesSignificant group differencesAmyotrophic lateral sclerosisTranslocator proteinMatched healthy controlsDetect group differencesWithin-group variabilityBack painNeuroimmune activationVoxelwise analysisPET scansHealthy controlsClinical cohortDistribution volume