2022
Epidemiology of atrial fibrillation in the All of Us Research Program
Alonso A, Alam A, Kamel H, Subbian V, Qian J, Boerwinkle E, Cicek M, Clark C, Cohn E, Gebo K, Loperena-Cortes R, Mayo K, Mockrin S, Ohno-Machado L, Schully S, Ramirez A, Greenland P. Epidemiology of atrial fibrillation in the All of Us Research Program. PLOS ONE 2022, 17: e0265498. PMID: 35294480, PMCID: PMC8926244, DOI: 10.1371/journal.pone.0265498.Peer-Reviewed Original ResearchConceptsAtrial fibrillationNon-Hispanic whitesUs Research ProgramRisk factorsEpidemiology of AFIncidence of AFPresence of AFHigher body mass indexStudy of AFClinical risk factorsIncident atrial fibrillationCoronary heart diseaseBody mass indexElectronic health record dataMedical history dataMedical history surveyNon-Hispanic blacksHealth record dataAvailable EHR dataNon-Hispanic AsiansHeart failureStudy enrollmentMass indexEligible participantsMean age
2021
Racial, ethnic, and gender differences in obesity and body fat distribution: An All of Us Research Program demonstration project
Karnes J, Arora A, Feng J, Steiner H, Sulieman L, Boerwinkle E, Clark C, Cicek M, Cohn E, Gebo K, Loperena-Cortes R, Ohno-Machado L, Mayo K, Mockrin S, Ramirez A, Schully S, Klimentidis Y. Racial, ethnic, and gender differences in obesity and body fat distribution: An All of Us Research Program demonstration project. PLOS ONE 2021, 16: e0255583. PMID: 34358277, PMCID: PMC8345840, DOI: 10.1371/journal.pone.0255583.Peer-Reviewed Original ResearchConceptsBody mass indexBody fat distributionNon-Hispanic blacksNon-Hispanic whitesAlanine aminotransferaseNHB participantsFat distributionAge-adjusted obesity prevalenceNutrition Examination Survey dataBaseline physical examinationRace/ethnicityElectronic health recordsNHB womenWaist circumferenceMass indexHip ratioNHB menPhysical examinationNational HealthObesity prevalenceObesity ratesGender differencesObesityUs Research ProgramNHW participantsHypertension prevalence in the All of Us Research Program among groups traditionally underrepresented in medical research
Chandler P, Clark C, Zhou G, Noel N, Achilike C, Mendez L, Ramirez A, Loperena-Cortes R, Mayo K, Cohn E, Ohno-Machado L, Boerwinkle E, Cicek M, Qian J, Schully S, Ratsimbazafy F, Mockrin S, Gebo K, Dedier J, Murphy S, Smoller J, Karlson E. Hypertension prevalence in the All of Us Research Program among groups traditionally underrepresented in medical research. Scientific Reports 2021, 11: 12849. PMID: 34158555, PMCID: PMC8219813, DOI: 10.1038/s41598-021-92143-w.Peer-Reviewed Original ResearchConceptsPrevalence of hypertensionHTN prevalenceUs Research ProgramMajor public health concernBlood pressure medicationsPopulation-based studyNutrition Examination SurveyBlood pressure measurementsPopulation-based surveyEHR dataPatient measurementsPublic health concernAntihypertensive medicationsEHR cohortHTN medicationsHypertension prevalenceCrude prevalenceHypertension casesHypertension treatmentExamination SurveyNational HealthHypertensionBilling codesMedicationsCohort
2020
Engaging heart failure patients from a clinical data research network: A survey on willingness to participate in different types of research.
Choi Y, López J, Meeker D, Ohno-Machado L, Kim K. Engaging heart failure patients from a clinical data research network: A survey on willingness to participate in different types of research. AMIA Annual Symposium Proceedings 2020, 2019: 305-312. PMID: 32308823, PMCID: PMC7153117.Peer-Reviewed Original ResearchConceptsClinical Data Research NetworkHeart failure patientsLarge cohort studyResearch participationResearch NetworkCohort studyFailure patientsOne-time surveyPatient cohortObservational studyPatient motivationWeight controlSignificant associationClinical researchPatientsPrecision medicineHealth dataRecruitment effortsNational effortsActivity interestsSurgeryCohort
2019
Patient Perspectives About Decisions to Share Medical Data and Biospecimens for Research
Kim J, Kim H, Bell E, Bath T, Paul P, Pham A, Jiang X, Zheng K, Ohno-Machado L. Patient Perspectives About Decisions to Share Medical Data and Biospecimens for Research. JAMA Network Open 2019, 2: e199550. PMID: 31433479, PMCID: PMC6707015, DOI: 10.1001/jamanetworkopen.2019.9550.Peer-Reviewed Original ResearchTime Requirements of Paper-Based Clinical Workflows and After-Hours Documentation in a Multispecialty Academic Ophthalmology Practice
Baxter S, Gali H, Huang A, Millen M, El-Kareh R, Nudleman E, Robbins S, Heichel C, Camp A, Korn B, Lee J, Kikkawa D, Longhurst C, Chiang M, Hribar M, Ohno-Machado L. Time Requirements of Paper-Based Clinical Workflows and After-Hours Documentation in a Multispecialty Academic Ophthalmology Practice. American Journal Of Ophthalmology 2019, 206: 161-167. PMID: 30910517, PMCID: PMC6755078, DOI: 10.1016/j.ajo.2019.03.014.Peer-Reviewed Original ResearchConceptsPatient encountersNew patient evaluationsClinical workflowElectronic health record useOutpatient ophthalmology clinicHigh clinical volumeAcademic ophthalmology departmentsAcademic ophthalmology practicePaper-based documentationAge 43.9Postoperative visitRoutine followClinic hoursOphthalmology clinicOphthalmology departmentPatient evaluationOphthalmology practiceOutcome measurementsPatientsPatient careHours workRecord useOphthalmologistsClinical volumeTotal time
2018
Obesity Is Independently Associated With Higher Annual Burden and Costs of Hospitalization in Patients With Inflammatory Bowel Diseases
Nguyen N, Ohno-Machado L, Sandborn W, Singh S. Obesity Is Independently Associated With Higher Annual Burden and Costs of Hospitalization in Patients With Inflammatory Bowel Diseases. Clinical Gastroenterology And Hepatology 2018, 17: 709-718.e7. PMID: 30012429, DOI: 10.1016/j.cgh.2018.07.004.Peer-Reviewed Original ResearchConceptsNon-obese patientsInflammatory bowel diseaseNationwide Readmissions Database 2013Cost of hospitalizationBowel diseaseObese patientsAnnual burdenPropensity scoreHospitalization-related costsOutcomes of hospitalizationRepresentative cohort studyHigh-cost patientsCardiopulmonary complicationsIBD patientsAdjunctive therapyCohort studyIBD phenotypePreventable admissionsHigh burdenPatientsHospitalizationObesityAbstractTextObeseInconsistent associationsInfections and Cardiovascular Complications are Common Causes for Hospitalization in Older Patients with Inflammatory Bowel Diseases
Nguyen N, Ohno-Machado L, Sandborn W, Singh S. Infections and Cardiovascular Complications are Common Causes for Hospitalization in Older Patients with Inflammatory Bowel Diseases. Inflammatory Bowel Diseases 2018, 24: 916-923. PMID: 29562273, DOI: 10.1093/ibd/izx089.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseOlder patientsYounger patientsAnnual burdenNationwide Readmissions Database 2013Treatment-related complicationsDisease-related complicationsCause of hospitalizationRepresentative cohort studyCohort studyBowel diseaseHigh riskPatientsMore daysHospitalizationComplicationsBurdenCauseRehospitalizationHospitalTherapyCohortPrevalenceDiseaseAnnual Burden and Costs of Hospitalization for High-Need, High-Cost Patients With Chronic Gastrointestinal and Liver Diseases
Nguyen NH, Khera R, Ohno-Machado L, Sandborn WJ, Singh S. Annual Burden and Costs of Hospitalization for High-Need, High-Cost Patients With Chronic Gastrointestinal and Liver Diseases. Clinical Gastroenterology And Hepatology 2018, 16: 1284-1292.e30. PMID: 29474966, PMCID: PMC6056327, DOI: 10.1016/j.cgh.2018.02.015.Peer-Reviewed Original ResearchConceptsFunctional gastrointestinal disordersChronic liver diseaseInflammatory bowel diseaseHigh-cost patientsCost of hospitalizationGastrointestinal hemorrhageLiver diseasePancreatic diseaseChronic gastrointestinalHospitalization costsAnnual burdenNationwide Readmissions Database 2013Medicare/Medicaid insuranceHigher comorbidity burdenInfection-related hospitalizationNationwide database analysisMultivariate logistic regressionDays/monthLarge rural hospitalPopulation health managementLow-income statusCardiopulmonary causesComorbidity burdenIndex hospitalizationHigh-value care
2017
A Predictive Model for Extended Postanesthesia Care Unit Length of Stay in Outpatient Surgeries
Gabriel R, Waterman R, Kim J, Ohno-Machado L. A Predictive Model for Extended Postanesthesia Care Unit Length of Stay in Outpatient Surgeries. Anesthesia & Analgesia 2017, 124: 1529-1536. PMID: 28079580, DOI: 10.1213/ane.0000000000001827.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAged, 80 and overAmbulatory Surgical ProceduresAnesthesiaChildChild, PreschoolCritical CareFemaleForecastingHumansHypertensionInfantInfant, NewbornIntensive Care UnitsLength of StayLogistic ModelsMaleMiddle AgedModels, StatisticalObesity, MorbidPostoperative CareRisk FactorsROC CurveYoung AdultConceptsPACU lengthPostanesthesia care unit lengthPrimary anesthesia typePostanesthesia care unitHosmer-Lemeshow testLogistic regression modelsAnesthesia typeMorbid obesityCare unitHL testOutpatient surgeryOutpatient procedureSingle institutionHigher oddsNonsignificant P valuesStayPatientsSurgical specialtiesROC curveGood calibrationCharacteristic curveExcellent discriminationAUC valuesP-valueBackward elimination
2012
Reviewing social media use by clinicians
von Muhlen M, Ohno-Machado L. Reviewing social media use by clinicians. Journal Of The American Medical Informatics Association 2012, 19: 777-781. PMID: 22759618, PMCID: PMC3422846, DOI: 10.1136/amiajnl-2012-000990.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSocial media useMedia useSocial mediaSocial media guidelinesMedia guidelinesFacebook accountsUnprofessional contentWikipediaSocial networksHighlight trendsReference toolAdoption surveysStudentsMediumInstitutional responsesProfessional cliniciansScience studentsPatient confidentialityMixed successArticleAuthorsCallsHealth science students
2006
Supratentorial Low-Grade Glioma Resectability: Statistical Predictive Analysis Based on Anatomic MR Features and Tumor Characteristics
Talos I, Zou K, Ohno-Machado L, Bhagwat J, Kikinis R, Black P, Jolesz F. Supratentorial Low-Grade Glioma Resectability: Statistical Predictive Analysis Based on Anatomic MR Features and Tumor Characteristics. Radiology 2006, 239: 506-13. PMID: 16641355, PMCID: PMC1475754, DOI: 10.1148/radiol.2392050661.Peer-Reviewed Original Research
2005
A global goodness-of-fit test for receiver operating characteristic curve analysis via the bootstrap method
Zou K, Resnic F, Talos I, Goldberg-Zimring D, Bhagwat J, Haker S, Kikinis R, Jolesz F, Ohno-Machado L. A global goodness-of-fit test for receiver operating characteristic curve analysis via the bootstrap method. Journal Of Biomedical Informatics 2005, 38: 395-403. PMID: 16198998, DOI: 10.1016/j.jbi.2005.02.004.Peer-Reviewed Original ResearchAdolescentAdultAlgorithmsAngioplasty, Balloon, CoronaryBrain NeoplasmsCalibrationData Interpretation, StatisticalDecision Support Systems, ClinicalDiagnosis, Computer-AssistedDiscriminant AnalysisExpert SystemsFemaleHumansIncidenceMaleMiddle AgedOutcome Assessment, Health CarePrognosisRisk AssessmentRisk FactorsROC CurveSurvival AnalysisSurvival RateUnited States
2004
Prediction of mortality in an Indian intensive care unit
Nimgaonkar A, Karnad D, Sudarshan S, Ohno-Machado L, Kohane I. Prediction of mortality in an Indian intensive care unit. Intensive Care Medicine 2004, 30: 248-253. PMID: 14727015, DOI: 10.1007/s00134-003-2105-4.Peer-Reviewed Original ResearchConceptsNeural networkIndian data setAPACHE IIArtificial neural network modelBack-propagation algorithmNeural network modelAnalysis of informationDay 1 APACHE II scoreIndian Intensive Care UnitsNetwork modelAPACHE II equationAPACHE II systemAPACHE II scoreIntensive care unitRisk of deathPrediction of mortalityNetworkHosmer-Lemeshow statisticData setsLogistic regression modelsHospital outcomesII scoreCare unitUniversity HospitalConsecutive admissions
1993
Prognostic classification for aids patients in Brazil
Ohno-Machado L. Prognostic classification for aids patients in Brazil. Journal Of Medical Systems 1993, 17: 163-172. PMID: 8254260, DOI: 10.1007/bf00996941.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdolescentAdultAgedAIDS-Related Opportunistic InfectionsBrazilCause of DeathChildChild, PreschoolCross-Sectional StudiesDeveloping CountriesDiscriminant AnalysisFemaleHospitalizationHumansIncidenceInfantInfant, NewbornMaleMiddle AgedNeoplasmsSurvival RateConceptsHospitalized AIDS patientsPrognosis of deathHistory of transfusionGroup IV patientsNumber of infectionsEsophageal candidiasisIV patientsAIDS patientsFirst manifestationAID patientsRisk groupsPrognostic classificationPrognostic variablesSurvival ratePatientsFinal discriminant functionInfectionDiseaseDeathAnalysis groupHospitalizationTransfusionPrognosisGroupCandidiasis