2015
WebDISCO: a web service for distributed cox model learning without patient-level data sharing
Lu C, Wang S, Ji Z, Wu Y, Xiong L, Jiang X, Ohno-Machado L. WebDISCO: a web service for distributed cox model learning without patient-level data sharing. Journal Of The American Medical Informatics Association 2015, 22: 1212-1219. PMID: 26159465, PMCID: PMC5009917, DOI: 10.1093/jamia/ocv083.Peer-Reviewed Original ResearchA system to build distributed multivariate models and manage disparate data sharing policies: implementation in the scalable national network for effectiveness research
Meeker D, Jiang X, Matheny M, Farcas C, D’Arcy M, Pearlman L, Nookala L, Day M, Kim K, Kim H, Boxwala A, El-Kareh R, Kuo G, Resnic F, Kesselman C, Ohno-Machado L. A system to build distributed multivariate models and manage disparate data sharing policies: implementation in the scalable national network for effectiveness research. Journal Of The American Medical Informatics Association 2015, 22: 1187-1195. PMID: 26142423, PMCID: PMC4639714, DOI: 10.1093/jamia/ocv017.Peer-Reviewed Original ResearchConceptsFederated networkData sharing policiesParallel computation methodSharing policiesPolicy management systemData exchange policiesData storage requirementsWeb servicesNetwork queriesQuery functionalityComputation resourcesFederated modelGraphical interfaceData transportCentralized networkStorage requirementsNetwork participantsManagement systemQueriesNetworkComputation methodNew featuresMultivariate statistical estimationDifferent state lawsImportant new feature
2014
MAGI: a Node.js web service for fast microRNA-Seq analysis in a GPU infrastructure
Kim J, Levy E, Ferbrache A, Stepanowsky P, Farcas C, Wang S, Brunner S, Bath T, Wu Y, Ohno-Machado L. MAGI: a Node.js web service for fast microRNA-Seq analysis in a GPU infrastructure. Bioinformatics 2014, 30: 2826-2827. PMID: 24907367, PMCID: PMC4173015, DOI: 10.1093/bioinformatics/btu377.Peer-Reviewed Original ResearchConceptsWeb servicesWeb reportsLarge input filesNovel feature extractionEnd performance improvementsExploration of resultsGPU infrastructureInteractive visualizationJavaScript frameworkParallel computingGPU devicesHypertext PreprocessorCUDA CFeature extractionDrop operationInput filesPlot generationSalient featuresPerformance improvementInfrastructureNodesServicesData analysisComputingBrowsermiRIAD—integrating microRNA inter- and intragenic data
Hinske L, França G, Torres H, Ohara D, Lopes-Ramos C, Heyn J, Reis L, Ohno-Machado L, Kreth S, Galante P. miRIAD—integrating microRNA inter- and intragenic data. Database 2014, 2014: bau099. PMID: 25288656, PMCID: PMC4186326, DOI: 10.1093/database/bau099.Peer-Reviewed Original ResearchConceptsProtein-coding genesIntragenic miRNAsHost genesGene expressionProtein-protein interaction dataSmall non-coding RNAsHost gene functionHost gene expressionMiRNA binding sitesNon-coding RNAsMajority of miRNAsGene functionGenomic contextFunctional annotationFunctional network analysisTarget mRNAsExpression correlationExonic regionsGenesMiRNAsDifferent tissuesInteraction dataBinding sitesGenomic classificationSilico validation
2013
Game changer: how informatics moved from a supporting role to a central position in healthcare
Ohno-Machado L. Game changer: how informatics moved from a supporting role to a central position in healthcare. Journal Of The American Medical Informatics Association 2013, 20: e197-e197. PMID: 24302668, PMCID: PMC3861937, DOI: 10.1136/amiajnl-2013-002434.Commentaries, Editorials and LettersWebGLORE: a Web service for Grid LOgistic REgression
Jiang W, Li P, Wang S, Wu Y, Xue M, Ohno-Machado L, Jiang X. WebGLORE: a Web service for Grid LOgistic REgression. Bioinformatics 2013, 29: 3238-3240. PMID: 24072732, PMCID: PMC3842761, DOI: 10.1093/bioinformatics/btt559.Peer-Reviewed Original ResearchConceptsWeb servicesHypertext Transfer Protocol SecurePrivacy-preserving constructionFree Software FoundationGNU General Public LicenseUse web serviceFree web serviceGeneral Public LicenseDistributed datasetsTrusted serverProtocol SecureSoftware FoundationPublic LicensePHP technologyInformation exchangeBiomedical researchersLocal statisticsServicesServletsServerSecureAjaxGlobal logistic regression modelDatasetGlobal model
2012
A collaborative framework for Distributed Privacy-Preserving Support Vector Machine learning.
Que J, Jiang X, Ohno-Machado L. A collaborative framework for Distributed Privacy-Preserving Support Vector Machine learning. AMIA Annual Symposium Proceedings 2012, 2012: 1350-9. PMID: 23304414, PMCID: PMC3540462.Peer-Reviewed Original ResearchConceptsSupport vector machineVector machinePrivacy-preserving collaborative learningSensitive raw dataPrivacy-preserving mannerEfficient information exchangeDistributed PrivacyLocal repositoryPrivacy concernsCentralized repositoryCollaborative frameworkDecision supportMultiple participantsInformation exchangeRaw dataSVM modelIntermediary resultsMachineCollaborative learningPrivacyPopular toolRepositoryTraditional wayPatient dataServerSPLOOCE
Kroll J, Galante P, Ohara D, Navarro F, Ohno-Machado L, de Souza S. SPLOOCE. RNA Biology 2012, 9: 1339-1343. PMID: 23064119, PMCID: PMC3597574, DOI: 10.4161/rna.22182.Peer-Reviewed Original ResearchReviewing social media use by clinicians
von Muhlen M, Ohno-Machado L. Reviewing social media use by clinicians. Journal Of The American Medical Informatics Association 2012, 19: 777-781. PMID: 22759618, PMCID: PMC3422846, DOI: 10.1136/amiajnl-2012-000990.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSocial media useMedia useSocial mediaSocial media guidelinesMedia guidelinesFacebook accountsUnprofessional contentWikipediaSocial networksHighlight trendsReference toolAdoption surveysStudentsMediumInstitutional responsesProfessional cliniciansScience studentsPatient confidentialityMixed successArticleAuthorsCallsHealth science studentsSetting Up an Intronic miRNA Database
Hinske L, Heyn J, Galante P, Ohno-Machado L, Kreth S. Setting Up an Intronic miRNA Database. Methods In Molecular Biology 2012, 936: 69-76. PMID: 23007499, DOI: 10.1007/978-1-62703-083-0_5.Peer-Reviewed Original ResearchConceptsAvailable information resourcesWeb-based toolInformation resourcesGenome-wide analysisHost gene transcriptionAnalysis techniquesIntergenic miRNAsIntragenic microRNAsWide analysisUseful analysis techniqueHost genesMiRNA databaseGene transcriptionMiRNA dataDifferent analysis techniquesMiRNAsSignificant attentionTranscriptionDatabaseMore informationRecent pastBasic structureTechniqueUnique linkageGenes
2002
Building an asynchronous web-based tool for machine learning classification.
Weber G, Vinterbo S, Ohno-Machado L. Building an asynchronous web-based tool for machine learning classification. AMIA Annual Symposium Proceedings 2002, 869-73. PMID: 12463949, PMCID: PMC2244467.Peer-Reviewed Original ResearchConceptsClassification methodDownloadable software toolsWeb-based applicationSupervised learning methodsSupport vector machineNearest neighbor classifierWeb-based toolWeb-based analysis toolWeb applicationBioinformatics LaboratorySoftware toolsFree softwareLearning methodsSophisticated algorithmsVector machineNeighbor classifierLinear discriminant analysisAnalysis toolsDisease classificationClassification treesLimited budgetShort amountRemote locationsHigh-throughput gene expression dataGene expression dataTraining in health informatics in Brazil.
Marques E, Marin H, Massad E, Fraser H, Ohno-Machado L. Training in health informatics in Brazil. 2002, 90: 757-60. PMID: 15460793.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements