2022
Comparative Safety and Effectiveness of Biologic Therapy for Crohn’s Disease: A CA-IBD Cohort Study
Singh S, Kim J, Luo J, Paul P, Rudrapatna V, Park S, Zheng K, Syal G, Ha C, Fleshner P, McGovern D, Sauk J, Limketkai B, Dulai P, Boland B, Eisenstein S, Ramamoorthy S, Melmed G, Mahadevan U, Sandborn W, Ohno-Machado L. Comparative Safety and Effectiveness of Biologic Therapy for Crohn’s Disease: A CA-IBD Cohort Study. Clinical Gastroenterology And Hepatology 2022, 21: 2359-2369.e5. PMID: 36343846, DOI: 10.1016/j.cgh.2022.10.029.Peer-Reviewed Original ResearchConceptsTNF-α antagonistsRisk of hospitalizationUstekinumab-treated patientsCrohn's diseaseSerious infectionsLower riskMulticenter cohortInflammatory bowel disease-related surgeryTumor necrosis factor α antagonistsNecrosis factor α antagonistsDisease-related surgeryHigher comorbidity burdenVedolizumab-treated patientsNew biologic agentsPropensity-score matchingComorbidity burdenCause hospitalizationAdult patientsBiologic therapyCohort studyPrior hospitalizationBiologic agentsΑ antagonistsBiologic classesComparative safety
2020
Active Surveillance of the Implantable Cardioverter-Defibrillator Registry for Defibrillator Lead Failures
Resnic F, Majithia A, Dhruva S, Ssemaganda H, Robbins S, Marinac-Dabic D, Hewitt K, Ohno-Machado L, Reynolds M, Matheny M. Active Surveillance of the Implantable Cardioverter-Defibrillator Registry for Defibrillator Lead Failures. Circulation Cardiovascular Quality And Outcomes 2020, 13: e006105. PMID: 32283971, PMCID: PMC7360169, DOI: 10.1161/circoutcomes.119.006105.Peer-Reviewed Original ResearchConceptsICD RegistryLead failureActive surveillanceNational Cardiovascular Data Registry ICD RegistryImplantable Cardioverter-Defibrillator RegistryPrimary safety end pointPropensity-matched survival analysisRate of freedomSafety end pointLead failure rateLong-term safetySignificant patient harmDefibrillator lead failureEarly lead failureMonitoring of safetyComparator patientsContemporary ICDLead survivalMeaningful differencesOutcome ascertainmentFailure rateNew ICDPatient harmPatientsSurvival analysis
2009
Is there an advantage in scoring early embryos on more than one day?
Racowsky C, Ohno-Machado L, Kim J, Biggers J. Is there an advantage in scoring early embryos on more than one day? Human Reproduction 2009, 24: 2104-2113. PMID: 19493872, PMCID: PMC2727402, DOI: 10.1093/humrep/dep198.Peer-Reviewed Original Research
1998
Comparison of multiple prediction models for ambulation following spinal cord injury.
Rowland T, Ohno-Machado L, Ohrn A. Comparison of multiple prediction models for ambulation following spinal cord injury. AMIA Annual Symposium Proceedings 1998, 528-32. PMID: 9929275, PMCID: PMC2232380.Peer-Reviewed Original Research