2020
Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1β and IL-17 upregulation in alcoholic hepatitis mice
Eguchi A, Yan R, Pan S, Wu R, Kim J, Chen Y, Ansong C, Smith R, Tempaku M, Ohno-Machado L, Takei Y, Feldstein A, Tsukamoto H. Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1β and IL-17 upregulation in alcoholic hepatitis mice. Journal Of Molecular Medicine 2020, 98: 1021-1034. PMID: 32556367, PMCID: PMC7810220, DOI: 10.1007/s00109-020-01926-7.Peer-Reviewed Original ResearchConceptsHepatic stellate cellsAlcoholic liver diseaseAlcoholic hepatitisAH miceIL-1βHepatic macrophagesStellate cellsExtracellular vesiclesPrimary hepatic stellate cellsIL-17 upregulationIL-17 productionUpregulated IL-1βHepatocyte-derived extracellular vesiclesNovel murine modelTLR9-dependent mannerMacrophage IL-1βHepatitis miceIL-17Liver diseaseControl miceCytokine productionLiver pathologyLiver fibrogenesisMurine modelΑ-SMA
2008
Peripheral arterial occlusive disease: Global gene expression analyses suggest a major role for immune and inflammatory responses
Fu S, Zhao H, Shi J, Abzhanov A, Crawford K, Ohno-Machado L, Zhou J, Du Y, Kuo W, Zhang J, Jiang M, Jin J. Peripheral arterial occlusive disease: Global gene expression analyses suggest a major role for immune and inflammatory responses. BMC Genomics 2008, 9: 369. PMID: 18673543, PMCID: PMC2529314, DOI: 10.1186/1471-2164-9-369.Peer-Reviewed Original ResearchMeSH KeywordsAdultAtherosclerosisFemoral ArteryGene Expression ProfilingGene Expression RegulationGenes, MHC Class IIHumansInflammationMaleMiddle AgedOligonucleotide Array Sequence AnalysisPeripheral Vascular DiseasesReverse Transcriptase Polymerase Chain ReactionTranscription, GeneticUp-RegulationVasculitisConceptsAdvanced lesionsInflammatory responseDisease progressionArterial diseaseGene OntologyIntermediate lesionsInflammatory genesGenome-wide gene expression profilingReal-time RT-PCR validationGlobal gene expression analysisToll-like receptor signalingBackgroundPeripheral arterial diseaseFemoral artery samplesSignificant cardiovascular morbidityNatural killer cellsFalse discovery rateNormal femoral arteryRT-PCR validationGene expression analysisGene expression profilingAffymetrix microarray platformCardiovascular morbidityKiller cellsFemoral arteryKyoto Encyclopedia