2023
Guiding Principles to Address the Impact of Algorithm Bias on Racial and Ethnic Disparities in Health and Health Care
Chin M, Afsar-Manesh N, Bierman A, Chang C, Colón-Rodríguez C, Dullabh P, Duran D, Fair M, Hernandez-Boussard T, Hightower M, Jain A, Jordan W, Konya S, Moore R, Moore T, Rodriguez R, Shaheen G, Snyder L, Srinivasan M, Umscheid C, Ohno-Machado L. Guiding Principles to Address the Impact of Algorithm Bias on Racial and Ethnic Disparities in Health and Health Care. JAMA Network Open 2023, 6: e2345050. PMID: 38100101, PMCID: PMC11181958, DOI: 10.1001/jamanetworkopen.2023.45050.Peer-Reviewed Original Research
2022
Achieving a Representative Sample of Asian Americans in Biomedical Research Through Community-Based Approaches: Comparing Demographic Data in the All of Us Research Program With the American Community Survey
Randal F, Lozano P, Qi S, Maene C, Shah S, Mo Y, Ratsimbazafy F, Boerwinkle E, Cicek M, Clark C, Cohn E, Gebo K, Loperena R, Mayo K, Mockrin S, Ohno-Machado L, Schully S, Ramirez A, Aschebrook-Kilfoy B, Ahsan H, Lam H, Kim K. Achieving a Representative Sample of Asian Americans in Biomedical Research Through Community-Based Approaches: Comparing Demographic Data in the All of Us Research Program With the American Community Survey. Journal Of Transcultural Nursing 2022, 34: 59-67. PMID: 36398985, DOI: 10.1177/10436596221130796.Peer-Reviewed Original ResearchMeSH KeywordsAsianBiomedical ResearchEducational StatusHumansPopulation HealthSurveys and QuestionnairesUnited StatesInvestigation of hypertension and type 2 diabetes as risk factors for dementia in the All of Us cohort
Nagar S, Pemu P, Qian J, Boerwinkle E, Cicek M, Clark C, Cohn E, Gebo K, Loperena R, Mayo K, Mockrin S, Ohno-Machado L, Ramirez A, Schully S, Able A, Green A, Zuchner S, Jordan I, Meller R. Investigation of hypertension and type 2 diabetes as risk factors for dementia in the All of Us cohort. Scientific Reports 2022, 12: 19797. PMID: 36396674, PMCID: PMC9672061, DOI: 10.1038/s41598-022-23353-z.Peer-Reviewed Original ResearchConceptsAssociation of hypertensionPrevalence of dementiaType 2 diabetesRisk factorsUS populationRace/ethnicityHigh prevalenceLarge observational cohort studyMultivariable logistic regression modelRisk factor modificationObservational cohort studyT2D risk factorsInvestigation of hypertensionAssociation of T2DOdds of dementiaRace/ethnicity groupsAssociation of sexCross-sectional analysisLogistic regression modelsWorld Health OrganizationElectronic health recordsConcurrent hypertensionModifiable comorbiditiesCohort studyFinal cohortA tribute to Karen Greenwood and her contributions to the American Medical Informatics Association
Lehmann C, Brennan P, Detmer D, Jackson G, Ohno-Machado L, Safran C, Williamson J, Shortliffe E. A tribute to Karen Greenwood and her contributions to the American Medical Informatics Association. Journal Of The American Medical Informatics Association 2022, 29: 1011-1013. PMID: 35303086, PMCID: PMC9006698, DOI: 10.1093/jamia/ocac039.Commentaries, Editorials and LettersEpidemiology of atrial fibrillation in the All of Us Research Program
Alonso A, Alam A, Kamel H, Subbian V, Qian J, Boerwinkle E, Cicek M, Clark C, Cohn E, Gebo K, Loperena-Cortes R, Mayo K, Mockrin S, Ohno-Machado L, Schully S, Ramirez A, Greenland P. Epidemiology of atrial fibrillation in the All of Us Research Program. PLOS ONE 2022, 17: e0265498. PMID: 35294480, PMCID: PMC8926244, DOI: 10.1371/journal.pone.0265498.Peer-Reviewed Original ResearchConceptsAtrial fibrillationNon-Hispanic whitesUs Research ProgramRisk factorsEpidemiology of AFIncidence of AFPresence of AFHigher body mass indexStudy of AFClinical risk factorsIncident atrial fibrillationCoronary heart diseaseBody mass indexElectronic health record dataMedical history dataMedical history surveyNon-Hispanic blacksHealth record dataAvailable EHR dataNon-Hispanic AsiansHeart failureStudy enrollmentMass indexEligible participantsMean ageNLM's Sponsorship of Research in Biomedical Informatics (1985-2016).
Kuo T, Ohno-Machado L. NLM's Sponsorship of Research in Biomedical Informatics (1985-2016). Studies In Health Technology And Informatics 2022, 288: 64-73. PMID: 35102829, DOI: 10.3233/shti210982.Peer-Reviewed Original Research
2021
Geographic Variation in Obesity at the State Level in the All of Us Research Program
Clark C, Chandler P, Zhou G, Noel N, Achilike C, Mendez L, O’Connor G, Smoller J, Weiss S, Murphy S, Ommerborn M, Karnes J, Klimentidis Y, Jordan C, Hiatt R, Ramirez A, Loperena R, Mayo K, Cohn E, Ohno-Machado L, Boerwinkle E, Cicek M, Schully S, Mockrin S, Gebo K, Karlson E. Geographic Variation in Obesity at the State Level in the All of Us Research Program. Preventing Chronic Disease 2021, 18: e104. PMID: 34941480, PMCID: PMC8718125, DOI: 10.5888/pcd18.210094.Peer-Reviewed Original ResearchConceptsBody mass indexObesity prevalenceElectronic health recordsSevere obesityPrevalence estimatesParticipants' electronic health recordsObesity prevention strategiesNational population-based estimatesEHR dataPopulation-based estimatesOverall obesity prevalenceState-level geographic variationsPopulation health studiesUS participantsEnrollment visitMass indexObesity preventionHigh prevalenceHealth StudyPrecision health approachObesityPrevention strategiesUs Research ProgramLarge geographic variationsCohort dataRacial, ethnic, and gender differences in obesity and body fat distribution: An All of Us Research Program demonstration project
Karnes J, Arora A, Feng J, Steiner H, Sulieman L, Boerwinkle E, Clark C, Cicek M, Cohn E, Gebo K, Loperena-Cortes R, Ohno-Machado L, Mayo K, Mockrin S, Ramirez A, Schully S, Klimentidis Y. Racial, ethnic, and gender differences in obesity and body fat distribution: An All of Us Research Program demonstration project. PLOS ONE 2021, 16: e0255583. PMID: 34358277, PMCID: PMC8345840, DOI: 10.1371/journal.pone.0255583.Peer-Reviewed Original ResearchConceptsBody mass indexBody fat distributionNon-Hispanic blacksNon-Hispanic whitesAlanine aminotransferaseNHB participantsFat distributionAge-adjusted obesity prevalenceNutrition Examination Survey dataBaseline physical examinationRace/ethnicityElectronic health recordsNHB womenWaist circumferenceMass indexHip ratioNHB menPhysical examinationNational HealthObesity prevalenceObesity ratesGender differencesObesityUs Research ProgramNHW participantsHypertension prevalence in the All of Us Research Program among groups traditionally underrepresented in medical research
Chandler P, Clark C, Zhou G, Noel N, Achilike C, Mendez L, Ramirez A, Loperena-Cortes R, Mayo K, Cohn E, Ohno-Machado L, Boerwinkle E, Cicek M, Qian J, Schully S, Ratsimbazafy F, Mockrin S, Gebo K, Dedier J, Murphy S, Smoller J, Karlson E. Hypertension prevalence in the All of Us Research Program among groups traditionally underrepresented in medical research. Scientific Reports 2021, 11: 12849. PMID: 34158555, PMCID: PMC8219813, DOI: 10.1038/s41598-021-92143-w.Peer-Reviewed Original ResearchConceptsPrevalence of hypertensionHTN prevalenceUs Research ProgramMajor public health concernBlood pressure medicationsPopulation-based studyNutrition Examination SurveyBlood pressure measurementsPopulation-based surveyEHR dataPatient measurementsPublic health concernAntihypertensive medicationsEHR cohortHTN medicationsHypertension prevalenceCrude prevalenceHypertension casesHypertension treatmentExamination SurveyNational HealthHypertensionBilling codesMedicationsCohort
2020
Use of electronic health records to support a public health response to the COVID-19 pandemic in the United States: a perspective from 15 academic medical centers
Madhavan S, Bastarache L, Brown J, Butte A, Dorr D, Embi P, Friedman C, Johnson K, Moore J, Kohane I, Payne P, Tenenbaum J, Weiner M, Wilcox A, Ohno-Machado L. Use of electronic health records to support a public health response to the COVID-19 pandemic in the United States: a perspective from 15 academic medical centers. Journal Of The American Medical Informatics Association 2020, 28: 393-401. PMID: 33260207, PMCID: PMC7665546, DOI: 10.1093/jamia/ocaa287.Commentaries, Editorials and LettersA systematic literature review of Native American and Pacific Islanders’ perspectives on health data privacy in the United States
Taitingfong R, Bloss C, Triplett C, Cakici J, Garrison N, Cole S, Stoner J, Ohno-Machado L. A systematic literature review of Native American and Pacific Islanders’ perspectives on health data privacy in the United States. Journal Of The American Medical Informatics Association 2020, 27: 1987-1998. PMID: 33063114, PMCID: PMC7727344, DOI: 10.1093/jamia/ocaa235.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsNational Estimates of Financial Hardship From Medical Bills and Cost-related Medication Nonadherence in Patients With Inflammatory Bowel Diseases in the United States
Nguyen NH, Khera R, Dulai PS, Boland BS, Ohno-Machado L, Sandborn WJ, Singh S. National Estimates of Financial Hardship From Medical Bills and Cost-related Medication Nonadherence in Patients With Inflammatory Bowel Diseases in the United States. Inflammatory Bowel Diseases 2020, 27: 1068-1078. PMID: 33051681, PMCID: PMC8205631, DOI: 10.1093/ibd/izaa266.Peer-Reviewed Original ResearchConceptsCost-related medication nonadherenceInflammatory bowel diseaseBowel diseaseMedication nonadherenceFinancial toxicityMedical billsSelf-reported inflammatory bowel diseaseSubstantial health care needsUnplanned health care utilizationNational estimatesNational Health Interview SurveyHigh ED utilizationEmergency department utilizationHealth care utilizationHealth Interview SurveyTimes higher oddsHealth care needsCost-reducing behaviorsFinancial hardshipValue-based careED utilizationCare utilizationNational burdenHigher oddsHealth care affordabilityBurden and Outcomes of Fragmentation of Care in Hospitalized Patients With Inflammatory Bowel Diseases: A Nationally Representative Cohort
Nguyen N, Luo J, Ohno-Machado L, Sandborn W, Singh S. Burden and Outcomes of Fragmentation of Care in Hospitalized Patients With Inflammatory Bowel Diseases: A Nationally Representative Cohort. Inflammatory Bowel Diseases 2020, 27: 1026-1034. PMID: 32944753, PMCID: PMC8205632, DOI: 10.1093/ibd/izaa238.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseFragmentation of careHigh riskCohort studyBowel diseaseNationwide Readmissions Database 2013Nationally Representative CohortUS cohort studyRisk of surgeryNumber of patientsRepresentative cohort studyHealth care qualityHospital mortalityHospitalized patientsCohort 2Outpatient careChronic diseasesCohort 1Representative cohortPatientsSingle episodeReadmissionHospitalizationCare qualityCareCoronavirus: indexed data speed up solutions
Ohno-Machado L, Xu H. Coronavirus: indexed data speed up solutions. Nature 2020, 584: 192-192. PMID: 32782375, DOI: 10.1038/d41586-020-02331-3.Commentaries, Editorials and LettersPrevalence and Effects of Food Insecurity and Social Support on Financial Toxicity in and Healthcare Use by Patients With Inflammatory Bowel Diseases
Nguyen NH, Khera R, Ohno-Machado L, Sandborn WJ, Singh S. Prevalence and Effects of Food Insecurity and Social Support on Financial Toxicity in and Healthcare Use by Patients With Inflammatory Bowel Diseases. Clinical Gastroenterology And Hepatology 2020, 19: 1377-1386.e5. PMID: 32526341, PMCID: PMC7987215, DOI: 10.1016/j.cgh.2020.05.056.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseEmergency department useCost-related medicationFinancial toxicityBowel diseaseHealthcare useDepartment useSocial supportMedical billsInadequate social supportMultivariable analysisFood insecurityHigh financial toxicityPatientsFinancial hardshipSocial determinantsAbstractTextPopulation healthPrevalenceHealthcare deliveryMedicationsAdultsDiseaseFamily incomeToxicityActive Surveillance of the Implantable Cardioverter-Defibrillator Registry for Defibrillator Lead Failures
Resnic F, Majithia A, Dhruva S, Ssemaganda H, Robbins S, Marinac-Dabic D, Hewitt K, Ohno-Machado L, Reynolds M, Matheny M. Active Surveillance of the Implantable Cardioverter-Defibrillator Registry for Defibrillator Lead Failures. Circulation Cardiovascular Quality And Outcomes 2020, 13: e006105. PMID: 32283971, PMCID: PMC7360169, DOI: 10.1161/circoutcomes.119.006105.Peer-Reviewed Original ResearchConceptsICD RegistryLead failureActive surveillanceNational Cardiovascular Data Registry ICD RegistryImplantable Cardioverter-Defibrillator RegistryPrimary safety end pointPropensity-matched survival analysisRate of freedomSafety end pointLead failure rateLong-term safetySignificant patient harmDefibrillator lead failureEarly lead failureMonitoring of safetyComparator patientsContemporary ICDLead survivalMeaningful differencesOutcome ascertainmentFailure rateNew ICDPatient harmPatientsSurvival analysis
2018
Reflections on the journey of editing a scientific journal
Ohno-Machado L. Reflections on the journey of editing a scientific journal. Journal Of The American Medical Informatics Association 2018, 25: 1584-1585. PMID: 30541126, PMCID: PMC7647172, DOI: 10.1093/jamia/ocy167.Commentaries, Editorials and LettersA Novel Stakeholder Engagement Approach for Patient-centered Outcomes Research
Kim K, Khodyakov D, Marie K, Taras H, Meeker D, Campos H, Ohno-Machado L. A Novel Stakeholder Engagement Approach for Patient-centered Outcomes Research. Medical Care 2018, 56: s41-s47. PMID: 30074950, PMCID: PMC6143220, DOI: 10.1097/mlr.0000000000000790.Peer-Reviewed Original ResearchConceptsClinical Data Research NetworkPatient-centered outcomes researchEngagement of patientsOutcomes research studiesConditions of focusStakeholder advisory boardPatient-centered outcomes research studiesKawasaki diseaseHeart failurePatient advocatesPatientsClinical sitesOutcomes researchSignificant differencesHealth researchCliniciansResearch NetworkResearch prioritiesSetting of prioritiesEngagement strategiesAdvisory BoardFavorable opinionObesityEngagement principlesDiseaseInfections and Cardiovascular Complications are Common Causes for Hospitalization in Older Patients with Inflammatory Bowel Diseases
Nguyen N, Ohno-Machado L, Sandborn W, Singh S. Infections and Cardiovascular Complications are Common Causes for Hospitalization in Older Patients with Inflammatory Bowel Diseases. Inflammatory Bowel Diseases 2018, 24: 916-923. PMID: 29562273, DOI: 10.1093/ibd/izx089.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseOlder patientsYounger patientsAnnual burdenNationwide Readmissions Database 2013Treatment-related complicationsDisease-related complicationsCause of hospitalizationRepresentative cohort studyCohort studyBowel diseaseHigh riskPatientsMore daysHospitalizationComplicationsBurdenCauseRehospitalizationHospitalTherapyCohortPrevalenceDiseaseAnnual Burden and Costs of Hospitalization for High-Need, High-Cost Patients With Chronic Gastrointestinal and Liver Diseases
Nguyen NH, Khera R, Ohno-Machado L, Sandborn WJ, Singh S. Annual Burden and Costs of Hospitalization for High-Need, High-Cost Patients With Chronic Gastrointestinal and Liver Diseases. Clinical Gastroenterology And Hepatology 2018, 16: 1284-1292.e30. PMID: 29474966, PMCID: PMC6056327, DOI: 10.1016/j.cgh.2018.02.015.Peer-Reviewed Original ResearchConceptsFunctional gastrointestinal disordersChronic liver diseaseInflammatory bowel diseaseHigh-cost patientsCost of hospitalizationGastrointestinal hemorrhageLiver diseasePancreatic diseaseChronic gastrointestinalHospitalization costsAnnual burdenNationwide Readmissions Database 2013Medicare/Medicaid insuranceHigher comorbidity burdenInfection-related hospitalizationNationwide database analysisMultivariate logistic regressionDays/monthLarge rural hospitalPopulation health managementLow-income statusCardiopulmonary causesComorbidity burdenIndex hospitalizationHigh-value care