2022
Evaluation of available risk scores to predict multiple cardiovascular complications for patients with type 2 diabetes mellitus using electronic health records
Ho J, Staimez L, Narayan K, Ohno-Machado L, Simpson R, Hertzberg V. Evaluation of available risk scores to predict multiple cardiovascular complications for patients with type 2 diabetes mellitus using electronic health records. Computer Methods And Programs In Biomedicine Update 2022, 3: 100087. PMID: 37332899, PMCID: PMC10274317, DOI: 10.1016/j.cmpbup.2022.100087.Peer-Reviewed Original ResearchType 2 diabetes mellitusCardiovascular risk modelsElectronic health recordsDiabetes mellitusCardiovascular risk prediction modelsHealth recordsElectronic health record dataAvailable risk scoresMultiple cardiovascular complicationsType 2 diabetesHosmer-Lemeshow goodnessHealth record dataHosmer-Lemeshow statisticRisk prediction modelCardiovascular complicationsCardiovascular outcomesCardiovascular endpointsC-statisticRisk modelRisk scoreType 2PatientsSecondary analysisImpact of raceRecord dataSimplified Machine Learning Models Can Accurately Identify High-Need High-Cost Patients With Inflammatory Bowel Disease
Nguyen N, Patel S, Gabunilas J, Qian A, Cecil A, Jairath V, Sandborn W, Ohno-Machado L, Chen P, Singh S. Simplified Machine Learning Models Can Accurately Identify High-Need High-Cost Patients With Inflammatory Bowel Disease. Clinical And Translational Gastroenterology 2022, 13: e00507. PMID: 35905414, PMCID: PMC10476830, DOI: 10.14309/ctg.0000000000000507.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseUnplanned healthcare utilizationAdult patientsBowel diseaseHealthcare utilizationHealthcare costsLogistic regressionRetrospective cohort studyNationwide Readmissions DatabaseIdentification of patientsAdministrative claims dataHigh-cost patientsHNHC patientsCohort studyHospitalized patientsClaims dataHigh riskPatientsTraditional logistic regressionDerivation dataMean AUCIBDMean areaCharacteristic curveDiseaseEffectiveness and Safety of Biologic Therapy in Hispanic Vs Non-Hispanic Patients With Inflammatory Bowel Diseases: A CA-IBD Cohort Study
Nguyen N, Luo J, Paul P, Kim J, Syal G, Ha C, Rudrapatna V, Park S, Parekh N, Zheng K, Sauk J, Limketkai B, Fleshner P, Eisenstein S, Ramamoorthy S, Melmed G, Dulai P, Boland B, Mahadevan U, Sandborn W, Ohno-Machado L, McGovern D, Singh S. Effectiveness and Safety of Biologic Therapy in Hispanic Vs Non-Hispanic Patients With Inflammatory Bowel Diseases: A CA-IBD Cohort Study. Clinical Gastroenterology And Hepatology 2022, 21: 173-181.e5. PMID: 35644340, PMCID: PMC9701245, DOI: 10.1016/j.cgh.2022.05.008.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseNon-Hispanic patientsBiologic-treated patientsHispanic patientsSerious infectionsBiologic therapyBowel diseasePropensity score-matched cohortBurden of inflammationRisk of hospitalizationHigh ratePropensity-score matchingCause hospitalizationAdult patientsBiologic initiationCohort studyBiologic agentsMedication useHigh burdenHigh riskHospitalizationPatientsSurvival analysisSurgeryAbstractTextInclusion of social determinants of health improves sepsis readmission prediction models
Amrollahi F, Shashikumar S, Meier A, Ohno-Machado L, Nemati S, Wardi G. Inclusion of social determinants of health improves sepsis readmission prediction models. Journal Of The American Medical Informatics Association 2022, 29: 1263-1270. PMID: 35511233, PMCID: PMC9196687, DOI: 10.1093/jamia/ocac060.Peer-Reviewed Original ResearchConceptsUnplanned readmissionSepsis patientsReadmission modelsClinical/laboratory featuresSocial determinantsUnplanned hospital readmissionHigh-risk patientsObjective clinical dataLow predictive valueReadmission prediction modelsSepsis readmissionsLaboratory featuresSepsis casesHospital readmissionPredictive factorsClinical dataReadmissionHigh riskPredictive valueSDH factorsMedical carePatientsDemographic featuresLarger studyProgram cohortSu1018: UNPLANNED HEALTHCARE UTILIZATION AND SAFETY OF BIOLOGIC THERAPY IN HISPANIC VS. NON-HISPANIC PATIENTS WITH IBD
Nguyen N, Luo J, Paul P, Kim J, Syal G, Ha C, Rudrapatna V, Park S, Parekh N, Zheng K, Sauk J, Limketkai B, Fleshner P, Eisenstein S, Ramamoorthy S, Melmed G, Boland B, Mahadevan U, Sandborn W, Ohno-Machado L, Mcgovern D, Singh S. Su1018: UNPLANNED HEALTHCARE UTILIZATION AND SAFETY OF BIOLOGIC THERAPY IN HISPANIC VS. NON-HISPANIC PATIENTS WITH IBD. Gastroenterology 2022, 162: s-482-s-483. DOI: 10.1016/s0016-5085(22)61145-4.Peer-Reviewed Original Research454: OBESITY IS NOT ASSOCIATED WITH INCREASED RISK OF ADVERSE TREATMENT OUTCOMES OR SERIOUS INFECTION IN INFLAMMATORY BOWEL DISEASES PATIENTS (IBD) STARTING NEW BIOLOGIC THERAPY
Gu P, Luo J, Paul P, Limketkai B, Sauk J, Park S, Parekh N, Zheng K, Rudrapatna V, Syal G, Ha C, Mcgovern D, Melmed G, Fleshner P, Eisenstein S, Ramamoorthy S, Dulai P, Boland B, Mahadevan U, Ohno-Machado L, Sandborn W, Singh S. 454: OBESITY IS NOT ASSOCIATED WITH INCREASED RISK OF ADVERSE TREATMENT OUTCOMES OR SERIOUS INFECTION IN INFLAMMATORY BOWEL DISEASES PATIENTS (IBD) STARTING NEW BIOLOGIC THERAPY. Gastroenterology 2022, 162: s-101-s-102. DOI: 10.1016/s0016-5085(22)60253-1.Peer-Reviewed Original Research
2021
Machine Learning-based Prediction Models for Diagnosis and Prognosis in Inflammatory Bowel Diseases: A Systematic Review
Nguyen N, Picetti D, Dulai P, Jairath V, Sandborn W, Ohno-Machado L, Chen P, Singh S. Machine Learning-based Prediction Models for Diagnosis and Prognosis in Inflammatory Bowel Diseases: A Systematic Review. Journal Of Crohn's And Colitis 2021, 16: 398-413. PMID: 34492100, PMCID: PMC8919806, DOI: 10.1093/ecco-jcc/jjab155.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsInflammatory bowel diseaseBowel diseaseClinical dataHigh riskRisk predictionSystematic reviewAcute severe ulcerative colitisLongitudinal disease activitySevere ulcerative colitisAdverse clinical outcomesBias assessment toolRisk of biasAvailable clinical dataMachine learning-based prediction modelsPrediction model RiskDisease activityCohort studyUlcerative colitisClinical outcomesTreatment responseClinical applicabilityLearning-based prediction modelsExternal validationPatientsRisk
2020
Burden and Outcomes of Fragmentation of Care in Hospitalized Patients With Inflammatory Bowel Diseases: A Nationally Representative Cohort
Nguyen N, Luo J, Ohno-Machado L, Sandborn W, Singh S. Burden and Outcomes of Fragmentation of Care in Hospitalized Patients With Inflammatory Bowel Diseases: A Nationally Representative Cohort. Inflammatory Bowel Diseases 2020, 27: 1026-1034. PMID: 32944753, PMCID: PMC8205632, DOI: 10.1093/ibd/izaa238.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseFragmentation of careHigh riskCohort studyBowel diseaseNationwide Readmissions Database 2013Nationally Representative CohortUS cohort studyRisk of surgeryNumber of patientsRepresentative cohort studyHealth care qualityHospital mortalityHospitalized patientsCohort 2Outpatient careChronic diseasesCohort 1Representative cohortPatientsSingle episodeReadmissionHospitalizationCare qualityCarePrevalence and Effects of Food Insecurity and Social Support on Financial Toxicity in and Healthcare Use by Patients With Inflammatory Bowel Diseases
Nguyen NH, Khera R, Ohno-Machado L, Sandborn WJ, Singh S. Prevalence and Effects of Food Insecurity and Social Support on Financial Toxicity in and Healthcare Use by Patients With Inflammatory Bowel Diseases. Clinical Gastroenterology And Hepatology 2020, 19: 1377-1386.e5. PMID: 32526341, PMCID: PMC7987215, DOI: 10.1016/j.cgh.2020.05.056.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseEmergency department useCost-related medicationFinancial toxicityBowel diseaseHealthcare useDepartment useSocial supportMedical billsInadequate social supportMultivariable analysisFood insecurityHigh financial toxicityPatientsFinancial hardshipSocial determinantsAbstractTextPopulation healthPrevalenceHealthcare deliveryMedicationsAdultsDiseaseFamily incomeToxicityActive Surveillance of the Implantable Cardioverter-Defibrillator Registry for Defibrillator Lead Failures
Resnic F, Majithia A, Dhruva S, Ssemaganda H, Robbins S, Marinac-Dabic D, Hewitt K, Ohno-Machado L, Reynolds M, Matheny M. Active Surveillance of the Implantable Cardioverter-Defibrillator Registry for Defibrillator Lead Failures. Circulation Cardiovascular Quality And Outcomes 2020, 13: e006105. PMID: 32283971, PMCID: PMC7360169, DOI: 10.1161/circoutcomes.119.006105.Peer-Reviewed Original ResearchConceptsICD RegistryLead failureActive surveillanceNational Cardiovascular Data Registry ICD RegistryImplantable Cardioverter-Defibrillator RegistryPrimary safety end pointPropensity-matched survival analysisRate of freedomSafety end pointLead failure rateLong-term safetySignificant patient harmDefibrillator lead failureEarly lead failureMonitoring of safetyComparator patientsContemporary ICDLead survivalMeaningful differencesOutcome ascertainmentFailure rateNew ICDPatient harmPatientsSurvival analysisEngaging heart failure patients from a clinical data research network: A survey on willingness to participate in different types of research.
Choi Y, López J, Meeker D, Ohno-Machado L, Kim K. Engaging heart failure patients from a clinical data research network: A survey on willingness to participate in different types of research. AMIA Annual Symposium Proceedings 2020, 2019: 305-312. PMID: 32308823, PMCID: PMC7153117.Peer-Reviewed Original ResearchConceptsClinical Data Research NetworkHeart failure patientsLarge cohort studyResearch participationResearch NetworkCohort studyFailure patientsOne-time surveyPatient cohortObservational studyPatient motivationWeight controlSignificant associationClinical researchPatientsPrecision medicineHealth dataRecruitment effortsNational effortsActivity interestsSurgeryCohortPromoting Quality Face-to-Face Communication during Ophthalmology Encounters in the Electronic Health Record Era
Baxter S, Gali H, Chiang M, Hribar M, Ohno-Machado L, El-Kareh R, Huang A, Chen H, Camp A, Kikkawa D, Korn B, Lee J, Longhurst C, Millen M. Promoting Quality Face-to-Face Communication during Ophthalmology Encounters in the Electronic Health Record Era. Applied Clinical Informatics 2020, 11: 130-141. PMID: 32074650, PMCID: PMC7030957, DOI: 10.1055/s-0040-1701255.Peer-Reviewed Original ResearchConceptsElectronic Health Record EraDocumentation efficiencyEHR implementationPhysician-patient interactionAcademic ophthalmology departmentsElectronic health recordsOutpatient ophthalmologyQuality improvement strategiesUse of scribesOutpatient encountersProspective studyOphthalmology departmentQI interventionsQI strategiesPatientsTeam-based workflowsEHR efficiencyNote templateArray of interventionsOphthalmologistsEHR useHealth recordsDocumentation timePhysician burnoutTablet-based application
2019
Impact of Electronic Health Record Implementation on Ophthalmology Trainee Time Expenditures
Gali H, Baxter S, Lander L, Huang A, Millen M, El-Kareh R, Nudleman E, Chao D, Robbins S, Heichel C, Camp A, Korn B, Lee J, Kikkawa D, Longhurst C, Chiang M, Hribar M, Ohno-Machado L. Impact of Electronic Health Record Implementation on Ophthalmology Trainee Time Expenditures. Journal Of Academic Ophthalmology 2019, 11: e65-e72. PMID: 33954272, PMCID: PMC8095731, DOI: 10.1055/s-0039-3401986.Peer-Reviewed Original ResearchTime-motion observationsElectronic health recordsOphthalmology traineesPatient encountersOphthalmology residentsEHR implementationEHR useMean total timeAcademic ophthalmology departmentsTime-motion studyElectronic health record implementationSubspecialty clinicsOphthalmology departmentClinical activityPatientsLinear mixed effects modelsEHR impactTotal timeTrainee burnoutPaper chartsHealth recordsDocumentation timeMixed effects modelsEffects modelWeeksTime Requirements of Paper-Based Clinical Workflows and After-Hours Documentation in a Multispecialty Academic Ophthalmology Practice
Baxter S, Gali H, Huang A, Millen M, El-Kareh R, Nudleman E, Robbins S, Heichel C, Camp A, Korn B, Lee J, Kikkawa D, Longhurst C, Chiang M, Hribar M, Ohno-Machado L. Time Requirements of Paper-Based Clinical Workflows and After-Hours Documentation in a Multispecialty Academic Ophthalmology Practice. American Journal Of Ophthalmology 2019, 206: 161-167. PMID: 30910517, PMCID: PMC6755078, DOI: 10.1016/j.ajo.2019.03.014.Peer-Reviewed Original ResearchConceptsPatient encountersNew patient evaluationsClinical workflowElectronic health record useOutpatient ophthalmology clinicHigh clinical volumeAcademic ophthalmology departmentsAcademic ophthalmology practicePaper-based documentationAge 43.9Postoperative visitRoutine followClinic hoursOphthalmology clinicOphthalmology departmentPatient evaluationOphthalmology practiceOutcome measurementsPatientsPatient careHours workRecord useOphthalmologistsClinical volumeTotal time
2018
Obesity Is Independently Associated With Higher Annual Burden and Costs of Hospitalization in Patients With Inflammatory Bowel Diseases
Nguyen N, Ohno-Machado L, Sandborn W, Singh S. Obesity Is Independently Associated With Higher Annual Burden and Costs of Hospitalization in Patients With Inflammatory Bowel Diseases. Clinical Gastroenterology And Hepatology 2018, 17: 709-718.e7. PMID: 30012429, DOI: 10.1016/j.cgh.2018.07.004.Peer-Reviewed Original ResearchConceptsNon-obese patientsInflammatory bowel diseaseNationwide Readmissions Database 2013Cost of hospitalizationBowel diseaseObese patientsAnnual burdenPropensity scoreHospitalization-related costsOutcomes of hospitalizationRepresentative cohort studyHigh-cost patientsCardiopulmonary complicationsIBD patientsAdjunctive therapyCohort studyIBD phenotypePreventable admissionsHigh burdenPatientsHospitalizationObesityAbstractTextObeseInconsistent associationsA Novel Stakeholder Engagement Approach for Patient-centered Outcomes Research
Kim K, Khodyakov D, Marie K, Taras H, Meeker D, Campos H, Ohno-Machado L. A Novel Stakeholder Engagement Approach for Patient-centered Outcomes Research. Medical Care 2018, 56: s41-s47. PMID: 30074950, PMCID: PMC6143220, DOI: 10.1097/mlr.0000000000000790.Peer-Reviewed Original ResearchConceptsClinical Data Research NetworkPatient-centered outcomes researchEngagement of patientsOutcomes research studiesConditions of focusStakeholder advisory boardPatient-centered outcomes research studiesKawasaki diseaseHeart failurePatient advocatesPatientsClinical sitesOutcomes researchSignificant differencesHealth researchCliniciansResearch NetworkResearch prioritiesSetting of prioritiesEngagement strategiesAdvisory BoardFavorable opinionObesityEngagement principlesDiseaseSu1886 - Burden of Hospitalization and Predictors of High Healthcare Utilization in Patients with Inflammatory Bowel Diseases in the United States
Nguyen N, Ohno-Machado L, Sandborn W, Singh S. Su1886 - Burden of Hospitalization and Predictors of High Healthcare Utilization in Patients with Inflammatory Bowel Diseases in the United States. Gastroenterology 2018, 154: s-620. DOI: 10.1016/s0016-5085(18)32232-7.Peer-Reviewed Original ResearchInfections and Cardiovascular Complications are Common Causes for Hospitalization in Older Patients with Inflammatory Bowel Diseases
Nguyen N, Ohno-Machado L, Sandborn W, Singh S. Infections and Cardiovascular Complications are Common Causes for Hospitalization in Older Patients with Inflammatory Bowel Diseases. Inflammatory Bowel Diseases 2018, 24: 916-923. PMID: 29562273, DOI: 10.1093/ibd/izx089.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseOlder patientsYounger patientsAnnual burdenNationwide Readmissions Database 2013Treatment-related complicationsDisease-related complicationsCause of hospitalizationRepresentative cohort studyCohort studyBowel diseaseHigh riskPatientsMore daysHospitalizationComplicationsBurdenCauseRehospitalizationHospitalTherapyCohortPrevalenceDisease
2017
Burden, Costs and Causes for Hospitalization in Older Patients With Inflammatory Bowel Diseases: A Nationally Representative Cohort Study
Nguyen N, Ohno-Machado L, Sandborn W, Singh S. Burden, Costs and Causes for Hospitalization in Older Patients With Inflammatory Bowel Diseases: A Nationally Representative Cohort Study. The American Journal Of Gastroenterology 2017, 112: s345. DOI: 10.14309/00000434-201710001-00628.Peer-Reviewed Original ResearchObesity Is Associated With Higher Annual Burden and Costs of Hospitalization in Patients With Inflammatory Bowel Diseases: A Nationally Representative Cohort Study
Nguyen N, Ohno-Machado L, Sandborn W, Singh S. Obesity Is Associated With Higher Annual Burden and Costs of Hospitalization in Patients With Inflammatory Bowel Diseases: A Nationally Representative Cohort Study. The American Journal Of Gastroenterology 2017, 112: s345. DOI: 10.14309/00000434-201710001-00629.Peer-Reviewed Original Research