2022
Simplified Machine Learning Models Can Accurately Identify High-Need High-Cost Patients With Inflammatory Bowel Disease
Nguyen N, Patel S, Gabunilas J, Qian A, Cecil A, Jairath V, Sandborn W, Ohno-Machado L, Chen P, Singh S. Simplified Machine Learning Models Can Accurately Identify High-Need High-Cost Patients With Inflammatory Bowel Disease. Clinical And Translational Gastroenterology 2022, 13: e00507. PMID: 35905414, PMCID: PMC10476830, DOI: 10.14309/ctg.0000000000000507.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseUnplanned healthcare utilizationAdult patientsBowel diseaseHealthcare utilizationHealthcare costsLogistic regressionRetrospective cohort studyNationwide Readmissions DatabaseIdentification of patientsAdministrative claims dataHigh-cost patientsHNHC patientsCohort studyHospitalized patientsClaims dataHigh riskPatientsTraditional logistic regressionDerivation dataMean AUCIBDMean areaCharacteristic curveDiseaseEffectiveness and Safety of Biologic Therapy in Hispanic Vs Non-Hispanic Patients With Inflammatory Bowel Diseases: A CA-IBD Cohort Study
Nguyen N, Luo J, Paul P, Kim J, Syal G, Ha C, Rudrapatna V, Park S, Parekh N, Zheng K, Sauk J, Limketkai B, Fleshner P, Eisenstein S, Ramamoorthy S, Melmed G, Dulai P, Boland B, Mahadevan U, Sandborn W, Ohno-Machado L, McGovern D, Singh S. Effectiveness and Safety of Biologic Therapy in Hispanic Vs Non-Hispanic Patients With Inflammatory Bowel Diseases: A CA-IBD Cohort Study. Clinical Gastroenterology And Hepatology 2022, 21: 173-181.e5. PMID: 35644340, PMCID: PMC9701245, DOI: 10.1016/j.cgh.2022.05.008.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseNon-Hispanic patientsBiologic-treated patientsHispanic patientsSerious infectionsBiologic therapyBowel diseasePropensity score-matched cohortBurden of inflammationRisk of hospitalizationHigh ratePropensity-score matchingCause hospitalizationAdult patientsBiologic initiationCohort studyBiologic agentsMedication useHigh burdenHigh riskHospitalizationPatientsSurvival analysisSurgeryAbstractTextInclusion of social determinants of health improves sepsis readmission prediction models
Amrollahi F, Shashikumar S, Meier A, Ohno-Machado L, Nemati S, Wardi G. Inclusion of social determinants of health improves sepsis readmission prediction models. Journal Of The American Medical Informatics Association 2022, 29: 1263-1270. PMID: 35511233, PMCID: PMC9196687, DOI: 10.1093/jamia/ocac060.Peer-Reviewed Original ResearchConceptsUnplanned readmissionSepsis patientsReadmission modelsClinical/laboratory featuresSocial determinantsUnplanned hospital readmissionHigh-risk patientsObjective clinical dataLow predictive valueReadmission prediction modelsSepsis readmissionsLaboratory featuresSepsis casesHospital readmissionPredictive factorsClinical dataReadmissionHigh riskPredictive valueSDH factorsMedical carePatientsDemographic featuresLarger studyProgram cohort
2021
Machine Learning-based Prediction Models for Diagnosis and Prognosis in Inflammatory Bowel Diseases: A Systematic Review
Nguyen N, Picetti D, Dulai P, Jairath V, Sandborn W, Ohno-Machado L, Chen P, Singh S. Machine Learning-based Prediction Models for Diagnosis and Prognosis in Inflammatory Bowel Diseases: A Systematic Review. Journal Of Crohn's And Colitis 2021, 16: 398-413. PMID: 34492100, PMCID: PMC8919806, DOI: 10.1093/ecco-jcc/jjab155.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsInflammatory bowel diseaseBowel diseaseClinical dataHigh riskRisk predictionSystematic reviewAcute severe ulcerative colitisLongitudinal disease activitySevere ulcerative colitisAdverse clinical outcomesBias assessment toolRisk of biasAvailable clinical dataMachine learning-based prediction modelsPrediction model RiskDisease activityCohort studyUlcerative colitisClinical outcomesTreatment responseClinical applicabilityLearning-based prediction modelsExternal validationPatientsRisk
2020
Burden and Outcomes of Fragmentation of Care in Hospitalized Patients With Inflammatory Bowel Diseases: A Nationally Representative Cohort
Nguyen N, Luo J, Ohno-Machado L, Sandborn W, Singh S. Burden and Outcomes of Fragmentation of Care in Hospitalized Patients With Inflammatory Bowel Diseases: A Nationally Representative Cohort. Inflammatory Bowel Diseases 2020, 27: 1026-1034. PMID: 32944753, PMCID: PMC8205632, DOI: 10.1093/ibd/izaa238.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseFragmentation of careHigh riskCohort studyBowel diseaseNationwide Readmissions Database 2013Nationally Representative CohortUS cohort studyRisk of surgeryNumber of patientsRepresentative cohort studyHealth care qualityHospital mortalityHospitalized patientsCohort 2Outpatient careChronic diseasesCohort 1Representative cohortPatientsSingle episodeReadmissionHospitalizationCare qualityCareFrailty Is Independently Associated with Mortality and Readmission in Hospitalized Patients with Inflammatory Bowel Diseases
Qian A, Nguyen N, Elia J, Ohno-Machado L, Sandborn W, Singh S. Frailty Is Independently Associated with Mortality and Readmission in Hospitalized Patients with Inflammatory Bowel Diseases. Clinical Gastroenterology And Hepatology 2020, 19: 2054-2063.e14. PMID: 32801013, PMCID: PMC7930013, DOI: 10.1016/j.cgh.2020.08.010.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseCause of hospitalizationHigh riskFrail patientsBowel diseaseSevere inflammatory bowel diseaseNationwide Readmissions DatabaseRisk of readmissionBurden of hospitalizationRisk of complicationsCost of hospitalizationBenefits of treatmentIndependent effectsRepresentative cohort studyIndex admissionMedian followCause readmissionComorbidity indexIndex hospitalizationCohort studyInpatient mortalityOlder patientsFrailty riskHospitalized patientsLongitudinal burden
2018
Infections and Cardiovascular Complications are Common Causes for Hospitalization in Older Patients with Inflammatory Bowel Diseases
Nguyen N, Ohno-Machado L, Sandborn W, Singh S. Infections and Cardiovascular Complications are Common Causes for Hospitalization in Older Patients with Inflammatory Bowel Diseases. Inflammatory Bowel Diseases 2018, 24: 916-923. PMID: 29562273, DOI: 10.1093/ibd/izx089.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseOlder patientsYounger patientsAnnual burdenNationwide Readmissions Database 2013Treatment-related complicationsDisease-related complicationsCause of hospitalizationRepresentative cohort studyCohort studyBowel diseaseHigh riskPatientsMore daysHospitalizationComplicationsBurdenCauseRehospitalizationHospitalTherapyCohortPrevalenceDisease