2015
Gene expression profiling in pachyonychia congenita skin
Cao YA, Hickerson RP, Seegmiller BL, Grapov D, Gross MM, Bessette MR, Phinney BS, Flores MA, Speaker TJ, Vermeulen A, Bravo AA, Bruckner AL, Milstone LM, Schwartz ME, Rice RH, Kaspar RL. Gene expression profiling in pachyonychia congenita skin. Journal Of Dermatological Science 2015, 77: 156-165. PMID: 25656049, PMCID: PMC4374015, DOI: 10.1016/j.jdermsci.2015.01.001.Peer-Reviewed Original ResearchConceptsPachyonychia congenitaTape-strip samplesPlantar skinSerine protease inhibitorNon-PC controlsPainful plantar keratodermaSkin barrier homeostasisPC patientsPatient groupControl volunteersMajor symptomsSkin biopsiesPC pathogenesisPlantar keratodermaPathogenic sequelaeSkin disordersBarrier homeostasisPatient samplesGene expression profilingKeratinocyte proliferationEnvelope proteinBiopsyMRNA analysisProtease inhibitorsSkin
1988
Human Keratinocytes Catabolize Thymidine
Schwartz P, Kugelman L, Coifman Y, Hough L, Milstone L. Human Keratinocytes Catabolize Thymidine. Journal Of Investigative Dermatology 1988, 90: 8-12. PMID: 3335793, DOI: 10.1111/1523-1747.ep12462412.Peer-Reviewed Original ResearchConceptsHuman keratinocytesHuman neonatal foreskinHuman neonatal foreskin keratinocytesNeonatal foreskin keratinocytesCutaneous diseaseSoluble extractsGuinea pigsNeonatal foreskinKeratinocyte proliferationForeskin keratinocytesStratified culturesRate of incorporationAdult skinRadioactive thymidineKeratinocytesThymidine analogueAmount of thymidineExogenous thymidineSpecies differencesThymidineHuman fibroblastsSkinCatabolismDifferent tissuesCulture medium