2004
Proapoptotic N-truncated BCL-xL protein activates endogenous mitochondrial channels in living synaptic terminals
Jonas EA, Hickman JA, Chachar M, Polster BM, Brandt TA, Fannjiang Y, Ivanovska I, Basañez G, Kinnally KW, Zimmerberg J, Hardwick JM, Kaczmarek LK. Proapoptotic N-truncated BCL-xL protein activates endogenous mitochondrial channels in living synaptic terminals. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 13590-13595. PMID: 15342906, PMCID: PMC518799, DOI: 10.1073/pnas.0401372101.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBcl-X ProteinDecapodiformesElectric ConductivityEndopeptidasesHypoxiaIon ChannelsLiposomesMitochondriaNADPatch-Clamp TechniquesPorinsPresynaptic TerminalsProtein Processing, Post-TranslationalProto-Oncogene Proteins c-bcl-2Sequence DeletionVoltage-Dependent Anion ChannelsConceptsBcl-xLMitochondrial channelsDeath pathwaysMitochondrial membraneBcl-xL.Proapoptotic Bcl-2 family proteinsVoltage-dependent anion channelBcl-2 family proteinsOuter mitochondrial membraneCell death pathwaysHydrophobic C-terminusBcl-xL proteinAntiapoptotic Bcl-xLNeuronal death pathwaysDeath stimuliBH3 domainFamily proteinsSquid presynaptic terminalsMammalian cellsC-terminusAnion channelMitochondriaChannel activityOpposite effectHealthy neurons
1990
Cyclic AMP regulates processing of neuropeptide precursor in bag cell neurons ofAplysia
Azhderian E, Kaczmarek L. Cyclic AMP regulates processing of neuropeptide precursor in bag cell neurons ofAplysia. Journal Of Molecular Neuroscience 1990, 2: 61-70. PMID: 1964064, DOI: 10.1007/bf02876912.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAplysiaColforsinCyclic AMPInvertebrate HormonesNeuronsProtein PrecursorsProtein Processing, Post-TranslationalTetrodotoxinTheophyllineConceptsBag cell neuronsEgg-laying hormoneCell neuronsCAMP levelsPresence of tetrodotoxinBag cell clustersAdenylate cyclase activator forskolinELH prohormoneCyclase activator forskolinElevation of cAMPMembrane-permeant cAMP analogAbdominal ganglionControl clustersPermeant cAMP analogueAction potentialsNeuroactive peptidesTreatment of cellsProtein synthesis inhibitor anisomycinActivator forskolinNeuronsProhormoneAfterdischargesCyclic AMPTetrodotoxinComparative peptide mapping