2023
Subsets of IFN Signaling Predict Response to Immune Checkpoint Blockade in Patients with Melanoma.
Horowitch B, Lee D, Ding M, Martinez-Morilla S, Aung T, Ouerghi F, Wang X, Wei W, Damsky W, Sznol M, Kluger H, Rimm D, Ishizuka J. Subsets of IFN Signaling Predict Response to Immune Checkpoint Blockade in Patients with Melanoma. Clinical Cancer Research 2023, 29: 2908-2918. PMID: 37233452, PMCID: PMC10524955, DOI: 10.1158/1078-0432.ccr-23-0215.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsHuman melanoma cell linesMelanoma cell linesPD-L1Validation cohortYale-New Haven HospitalCombination of ipilimumabPD-L1 markersImmune checkpoint blockadePD-L1 biomarkerNew Haven HospitalSTAT1 levelsCell linesWestern blot analysisCheckpoint inhibitorsCheckpoint blockadeClinical responseOverall survivalImproved survivalResistance of cancersMetastatic melanomaMelanoma responsePredict responseTreatment responseDistinct patterns
2019
Detection of pulmonary ground-glass opacity based on deep learning computer artificial intelligence
Ye W, Gu W, Guo X, Yi P, Meng Y, Han F, Yu L, Chen Y, Zhang G, Wang X. Detection of pulmonary ground-glass opacity based on deep learning computer artificial intelligence. BioMedical Engineering OnLine 2019, 18: 6. PMID: 30670024, PMCID: PMC6343356, DOI: 10.1186/s12938-019-0627-4.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsDatabases, FactualDeep LearningDiagnosis, Computer-AssistedFalse Positive ReactionsHumansImage Processing, Computer-AssistedLungLung NeoplasmsRadiographic Image Interpretation, Computer-AssistedRadiologyReproducibility of ResultsSensitivity and SpecificitySolitary Pulmonary NoduleTomography, X-Ray ComputedConceptsDeep learningF-scoreLung Image Database Consortium and Image Database Resource Initiative (LIDC-IDRI) databaseMethod of deep learningArtificial intelligence systemsInput imageNetwork trainingDetect pulmonary nodulesIdentification of lung nodulesIntelligent systemsNodule classificationGround-glass opacity imagesPreprocessing methodsDetect ground-glass opacitiesEvaluation resultsLearningAccuracyAlexNetResNet50PreprocessingImagesThree-dimensional featuresGround-glass opacitiesNetworkFeatures