2021
Anti-seizure medications and efficacy against focal to bilateral tonic-clonic seizures: A systematic review with relevance for SUDEP prevention
Cutillo G, Tolba H, Hirsch LJ. Anti-seizure medications and efficacy against focal to bilateral tonic-clonic seizures: A systematic review with relevance for SUDEP prevention. Epilepsy & Behavior 2021, 117: 107815. PMID: 33640562, DOI: 10.1016/j.yebeh.2021.107815.Peer-Reviewed Original ResearchConceptsAnti-seizure medicationsBilateral tonic-clonic seizuresTonic-clonic seizuresSUDEP preventionSystematic reviewPlacebo-controlled clinical trialFocal impaired awareness seizuresRisk of SUDEPSudden unexpected deathMajor risk factorAwareness seizuresRisk factorsClinical trialsUnexpected deathFBTCSHigh dosesSeizuresStrong associationSUDEPPreventionMedicationsTiagabineEfficacyLamotrigineBrivaracetam
2012
Sudden unexpected death in epilepsy in lamotrigine randomized‐controlled trials
Tomson T, Hirsch LJ, Friedman D, Bester N, Hammer A, Irizarry M, Ishihara L, Krishen A, Spaulding T, Wamil A, Leadbetter R. Sudden unexpected death in epilepsy in lamotrigine randomized‐controlled trials. Epilepsia 2012, 54: 135-140. PMID: 23030403, DOI: 10.1111/j.1528-1167.2012.03689.x.Peer-Reviewed Original ResearchConceptsSudden unexpected deathProbable SUDEPTreatment armsAntiepileptic drugsClinical trialsOdds ratioUnexpected deathTonic-clonic seizure frequencyRate of SUDEPRisk of SUDEPRandomized clinical trialsRandomized-controlled trialPotential risk factorsCause deathPossible SUDEPStudy medicationPatient yearsSeizure frequencyTreatment deathsComparator armActive comparatorNonrandomized studyUnadjusted ratesComparator groupRisk factors
2011
Abbreviated report of the NIH/NINDS workshop on sudden unexpected death in epilepsy(e–Pub ahead of print)
Hirsch LJ, Donner EJ, So EL, Jacobs M, Nashef L, Noebels JL, Buchhalter JR. Abbreviated report of the NIH/NINDS workshop on sudden unexpected death in epilepsy(e–Pub ahead of print). Neurology 2011, 76: 1932-1938. PMID: 21543734, PMCID: PMC3115809, DOI: 10.1212/wnl.0b013e31821de7de.Peer-Reviewed Original ResearchConceptsSudden infant death syndromeSudden unexpected deathSudden cardiac deathCardiac deathUnexpected deathAwareness of SUDEPPrevention of SUDEPRisk of SUDEPImproved seizure controlInfant death syndromeUnderstanding of SUDEPHealth care practitionersBasic science researchSUDEP incidenceDevastating complicationSeizure controlMulticenter collaborative researchSUDEPDeath syndromeAnimal modelsCare practitionersNeurological disordersEpilepsyPhysiologic featuresGenetic factors
2009
Report of the American Epilepsy Society and the Epilepsy Foundation Joint Task Force on Sudden Unexplained Death in Epilepsy
So EL, Bainbridge J, Buchhalter JR, Donalty J, Donner EJ, Finucane A, Graves NM, Hirsch LJ, Montouris GD, Temkin NR, Wiebe S, Sierzant TL. Report of the American Epilepsy Society and the Epilepsy Foundation Joint Task Force on Sudden Unexplained Death in Epilepsy. Epilepsia 2009, 50: 917-922. PMID: 19054406, DOI: 10.1111/j.1528-1167.2008.01906.x.Peer-Reviewed Original ResearchConceptsSudden unexplained deathAmerican Epilepsy SocietyRisk factorsUnexplained deathEpilepsy SocietyRisk of SUDEPPreventable risk factorsPossible preventive strategiesSurvey of patientsComplete autopsy examinationTask ForceTask Force recommendationsConsortium of centersConvulsive seizuresProspective studyBasic research studiesAutopsy examinationSUDEPSUDEP researchPreventive strategiesPatientsEpilepsy FoundationPosition statementCaregiversMedical examiners