2024
Comorbidity Profiles of Posttraumatic Stress Disorder Across the Medical Phenome
Hicks E, Niarchou M, Goleva S, Kabir D, Johnson J, Johnston K, Ciarcia J, Pathak G, Smoller J, Davis L, Nievergelt C, Koenen K, Huckins L, Choi K, Group P. Comorbidity Profiles of Posttraumatic Stress Disorder Across the Medical Phenome. Biological Psychiatry Global Open Science 2024, 4: 100337. PMID: 39050781, PMCID: PMC11268109, DOI: 10.1016/j.bpsgos.2024.100337.Peer-Reviewed Original ResearchElectronic health recordsClinical knowledge gapsPhysical health problemsPhenome-wide associationPheWAS analysisBiobank participantsHealth recordsEpidemiological researchHealthcare systemTest associationsMedical phenomeAssociated with osteoporosisPulmonary heart diseasePhecodesHealth problemsLogistic regressionPosttraumatic stress disorderSex differencesPheWASComorbidity profilesHeart diseaseStress disorderInteraction termsAssociationPTSD
2023
Modeling Gene by Environment Interactions in Post-Traumatic Stress Disorder Across the Post-Mortem Brain and in hiPSC-Derived Neurons
Seah C, Signer R, Young H, Rusielewicz T, Bader H, Xu C, dePins A, Breen M, Paull D, Girgenti M, Yehuda R, Brennand K, Huckins L. Modeling Gene by Environment Interactions in Post-Traumatic Stress Disorder Across the Post-Mortem Brain and in hiPSC-Derived Neurons. Biological Psychiatry 2023, 93: s11. DOI: 10.1016/j.biopsych.2023.02.048.Peer-Reviewed Original Research
2022
Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression
Seah C, Breen M, Rusielewicz T, Bader H, Xu C, Hunter C, McCarthy B, Deans P, Chattopadhyay M, Goldberg J, Desarnaud F, Makotkine I, Flory J, Bierer L, Staniskyte M, Noggle S, Huckins L, Paull D, Brennand K, Yehuda R. Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression. Nature Neuroscience 2022, 25: 1434-1445. PMID: 36266471, PMCID: PMC9630117, DOI: 10.1038/s41593-022-01161-y.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderPeripheral blood mononuclear cellsGlucocorticoid-induced changesGlucocorticoid-induced gene expressionBlood mononuclear cellsIndividual clinical outcomesEnvironmental risk factorsHuman postmortem brainGlucocorticoid hypersensitivityClinical outcomesGlutamatergic neuronsMononuclear cellsRisk factorsHydrocortisone exposureSevere traumaPostmortem brainsHuman neuronsGlucocorticoid responseInduced neuronsStress disorderNeuronsNew therapeuticsGene expressionGene × environment interactionsCombat veteransTrauma Matters: Integrating Genetic and Environmental Components of PTSD
Marchese S, Huckins L. Trauma Matters: Integrating Genetic and Environmental Components of PTSD. Advanced Genetics 2022, 4: 2200017. PMID: 37766803, PMCID: PMC10520418, DOI: 10.1002/ggn2.202200017.Peer-Reviewed Original Research
2020
Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts
Huckins L, Chatzinakos C, Breen M, Hartmann J, Klengel T, da Silva Almeida A, Dobbyn A, Girdhar K, Hoffman G, Klengel C, Logue M, Lori A, Maihofer A, Morrison F, Nguyen H, Park Y, Ruderfer D, Sloofman L, van Rooij S, Consortium P, Baker D, Chen C, Cox N, Duncan L, Geyer M, Glatt S, Im H, Risbrough V, Smoller J, Stein D, Yehuda R, Liberzon I, Koenen K, Jovanovic T, Kellis M, Miller M, Bacanu S, Nievergelt C, Buxbaum J, Sklar P, Ressler K, Stahl E, Daskalakis N. Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts. Cell Reports 2020, 31: 107716. PMID: 32492425, PMCID: PMC7359754, DOI: 10.1016/j.celrep.2020.107716.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCase-Control StudiesCohort StudiesDexamethasoneDown-RegulationGene Expression RegulationGene Regulatory NetworksGenetic Predisposition to DiseaseHumansLeukocytesMaleMiceMice, Inbred C57BLMilitary PersonnelPrefrontal CortexRepressor ProteinsRibonucleoproteins, Small NuclearRNA InterferenceRNA, Small InterferingStress Disorders, Post-TraumaticConceptsPost-traumatic stress disorderGenetically regulated gene expressionPost-traumatic stress disorder casesDorsolateral prefrontal cortexGene expressionU12 intron splicingPrefrontal cortexStress disorderDeployment stressTranscriptome imputationTissue-specific gene expressionDifferential gene expressionMilitary cohortZNF140U12 intronsGenetic heterogeneityExpression changesFunctional roleExogenous glucocorticoidsPeripheral leukocytesEuropean cohortCortexCohortDisordersExpression
2019
SU11 GENETICALLY PREDICTED GENE EXPRESSION IN THE BRAIN AND PERIPHERAL TISSUES ASSOCIATES WITH PTSD
Huckins L, Girdhar K, Dobbyn A, Jovanovic T, Nievergelt C, Hoffman G, Maihofer A, Stein M, Sklar P, Ressler K, Buxbaum J, Stahl E, Daskalakis N, Consortium T, Group P. SU11 GENETICALLY PREDICTED GENE EXPRESSION IN THE BRAIN AND PERIPHERAL TISSUES ASSOCIATES WITH PTSD. European Neuropsychopharmacology 2019, 29: s892-s893. DOI: 10.1016/j.euroneuro.2017.08.200.Peer-Reviewed Original ResearchPost-traumatic stress disorderPsychiatric disordersBrain regionsPost-traumatic stress disorder patientsPost-traumatic stress disorder developmentGenotype-Tissue ExpressionCommonMind ConsortiumIndividuals exposed to traumaDebilitating psychiatric disorderPeripheral tissuesGene expression prediction modelsGene expressionGene-tissue associationsPGC-PTSDStress disorderPTSD riskExpression prediction modelsTrauma typesMulti-system dysregulationImmune dysregulationGenotype dataDisordersGene associationsReference panelGenetic heterogeneity
2018
Recent Genetics and Epigenetics Approaches to PTSD
Daskalakis N, Rijal C, King C, Huckins L, Ressler K. Recent Genetics and Epigenetics Approaches to PTSD. Current Psychiatry Reports 2018, 20: 30. PMID: 29623448, PMCID: PMC6486832, DOI: 10.1007/s11920-018-0898-7.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderTrauma exposureGenome-wide association studiesEpigenetic approachesTargeted genetic studiesEpigenome-wide studiesInduce epigenetic changesResponse to trauma exposureAssociation studiesAdult trauma exposureGenetic studiesNegative emotional symptomsEpigenetic alterationsEpigenetic changesFunctional regulationEpigenetic riskIntrusive memoriesStress disorderTraumatic exposureImpaired cognitionEmotional symptomsAvoidance behaviorDisability syndromeBiological riskElectronic medical records