2021
Induction of dopaminergic neurons for neuronal subtype-specific modeling of psychiatric disease risk
Powell SK, O’Shea C, Townsley K, Prytkova I, Dobrindt K, Elahi R, Iskhakova M, Lambert T, Valada A, Liao W, Ho SM, Slesinger PA, Huckins LM, Akbarian S, Brennand KJ. Induction of dopaminergic neurons for neuronal subtype-specific modeling of psychiatric disease risk. Molecular Psychiatry 2021, 28: 1970-1982. PMID: 34493831, PMCID: PMC8898985, DOI: 10.1038/s41380-021-01273-0.Peer-Reviewed Original ResearchConceptsInduced dopaminergic neuronsDopaminergic neuronsMidbrain dopaminergic neuron developmentNeuron identityHuman induced pluripotent stem cellsCannabis use disorderDopaminergic neuron developmentAction potential durationGlutamatergic neuronsDopamine synthesisSpontaneous burstsPotential durationUse disordersNeuronal subtypesPsychiatric diseasesBipolar disorderElectrophysiological propertiesDisease riskHyperpolarization potentialPsychiatric disease riskNeuron developmentOscillatory activityNeuronsHeterogenous cell populationsCell populations
2013
Olfaction and olfactory-mediated behaviour in psychiatric disease models
Huckins L, Logan D, Sánchez-Andrade G. Olfaction and olfactory-mediated behaviour in psychiatric disease models. Cell And Tissue Research 2013, 354: 69-80. PMID: 23604803, DOI: 10.1007/s00441-013-1617-7.Peer-Reviewed Original ResearchConceptsOlfactory-mediated behaviorsPsychiatric diseasesRodent models of psychiatric disordersModels of psychiatric disordersModels of psychiatric diseaseTests of aggressionModel psychiatric diseaseAssociated with neuropsychiatric diseasesRodent modelsBehavioral paradigmsPsychiatric disordersOlfactory memoryExcellent sense of smellOlfactory functionNeuropsychiatric diseasesExperimental paradigmOlfactory dysfunctionAberrant behaviorBehavioral responsesOlfactory subsystemsEthological contextOlfactory componentsSense of smellSensory cuesSocial interaction