2018
Bacterial Lipoproteins Constitute the TLR2-Stimulating Activity of Serum Amyloid A
Burgess EJ, Hoyt LR, Randall MJ, Mank MM, Bivona JJ, Eisenhauer PL, Botten JW, Ballif BA, Lam YW, Wargo MJ, Boyson JE, Ather JL, Poynter ME. Bacterial Lipoproteins Constitute the TLR2-Stimulating Activity of Serum Amyloid A. The Journal Of Immunology 2018, 201: 2377-2384. PMID: 30158125, PMCID: PMC6179936, DOI: 10.4049/jimmunol.1800503.Peer-Reviewed Original ResearchConceptsEukaryotic cellsBacterial proteinsSerum amyloid ANumerous bacterial proteinsProteomic analysisMouse cellsRecombinant proteinsBacterial lipoproteinsProteinRecombinant serum amyloid ASAA1 proteinProinflammatory cytokine productionProduction of TNFCytokine productionProinflammatory functionsAmyloid ASerum amyloidCellsLipoprotein lipaseLipoproteinFuture studiesDifferentiationEscherichiaBindingLipopeptides
2016
Weight Loss Decreases Inherent and Allergic Methacholine Hyperresponsiveness in Mouse Models of Diet-Induced Obese Asthma
Ather JL, Chung M, Hoyt LR, Randall MJ, Georgsdottir A, Daphtary NA, Aliyeva MI, Suratt BT, Bates JH, Irvin CG, Russell SR, Forgione PM, Dixon AE, Poynter ME. Weight Loss Decreases Inherent and Allergic Methacholine Hyperresponsiveness in Mouse Models of Diet-Induced Obese Asthma. American Journal Of Respiratory Cell And Molecular Biology 2016, 55: 176-187. PMID: 27064658, PMCID: PMC4979374, DOI: 10.1165/rcmb.2016-0070oc.Peer-Reviewed Original ResearchConceptsDiet-induced weight lossObese asthmaMethacholine hyperresponsivenessWeight lossAsthma phenotypesMouse modelBariatric surgery-induced weight lossSurgery-induced weight lossFirmicutes/Bacteroidetes ratioAllergic asthma phenotypeDietary weight lossObese-asthma phenotypeSurgical weight lossSuccessful weight lossElevated proinflammatory cytokinesCentral airway resistanceDiet-induced obesityEnvironmental allergen exposureAdaptive immune responsesSubstantial weight lossDistinct anatomical compartmentsMethacholine responsivenessAllergic asthmaAllergen exposureAsthma symptoms