Uricase Inhibits Nitrogen Dioxide–Promoted Allergic Sensitization to Inhaled Ovalbumin Independent of Uric Acid Catabolism
Ather JL, Burgess EJ, Hoyt LR, Randall MJ, Mandal MK, Matthews DE, Boyson JE, Poynter ME. Uricase Inhibits Nitrogen Dioxide–Promoted Allergic Sensitization to Inhaled Ovalbumin Independent of Uric Acid Catabolism. The Journal Of Immunology 2016, 197: 1720-1732. PMID: 27465529, PMCID: PMC4992621, DOI: 10.4049/jimmunol.1600336.Peer-Reviewed Original ResearchConceptsAllergic airway diseaseAllergic sensitizationAirway diseaseUric acidDevelopment of OVAOVA-specific responsesAirways of miceUric acid levelsAdaptive immune responsesOVA-specific AbT cell proliferationPowerful inhibitory effectEnvironmental air pollutantsImmune deviationOVA challengeOVA uptakeDendritic cellsCytokine productionAdjuvant activityImmune responseRespiratory diseaseMouse modelUric acid formationInhibitory effectAcid levelsEthanol and Other Short-Chain Alcohols Inhibit NLRP3 Inflammasome Activation through Protein Tyrosine Phosphatase Stimulation
Hoyt LR, Ather JL, Randall MJ, DePuccio DP, Landry CC, Wewers MD, Gavrilin MA, Poynter ME. Ethanol and Other Short-Chain Alcohols Inhibit NLRP3 Inflammasome Activation through Protein Tyrosine Phosphatase Stimulation. The Journal Of Immunology 2016, 197: 1322-1334. PMID: 27421477, PMCID: PMC4975963, DOI: 10.4049/jimmunol.1600406.Peer-Reviewed Original ResearchConceptsTyrosine phosphorylationPattern recognition receptor complexTyrosine phosphatase inhibitor sodiumPhosphatase inhibitor sodiumCellular tyrosine phosphorylationNLRP3 inflammasome activationApical eventsNLRP3 inflammasomeProtein tyrosineMouse macrophage cell lineCARD (ASC) speck formationApoptosis-associated speck-like proteinMacrophage cell lineIL-1βInflammasome activationSpeck-like proteinReceptor complexMouse bone marrow-derived dendritic cellsBone marrow-derived dendritic cellsPhosphorylationMarrow-derived dendritic cellsProinflammatory cytokines IL-1βCell linesInhibitory effectCaspase-1 cleavage