2022
Ketone body augmentation decreases methacholine hyperresponsiveness in mouse models of allergic asthma
Mank M, Reed L, Fastiggi V, Peña-García P, Hoyt L, Van Der Vliet K, Ather J, Poynter M. Ketone body augmentation decreases methacholine hyperresponsiveness in mouse models of allergic asthma. Journal Of Allergy And Clinical Immunology Global 2022, 1: 282-298. PMID: 36466740, PMCID: PMC9718535, DOI: 10.1016/j.jacig.2022.08.001.Peer-Reviewed Original ResearchKetone ester supplementationMethacholine hyperresponsivenessAllergic asthmaAirway epithelial cellsKetogenic dietDose-dependent mannerKetone bodiesMouse modelElicit anti-inflammatory activityAllergic asthmatic individualsBronchial smooth muscle cellsChronic allergic asthmaHuman airway epithelial cellsEpithelial cellsProinflammatory cytokine secretionIL-8 secretionAnti-inflammatory activityBHB concentrationsSmooth muscle cellsKetone body precursorsRange of mildHDM sensitizationObese asthmaCell typesCorticosteroid treatment
2016
465 Protein S-Acylation in Pulmonary Disease
Randall M, Ather J, Hoyt L, Dixon A, Poynter M. 465 Protein S-Acylation in Pulmonary Disease. Free Radical Biology And Medicine 2016, 100: s193. DOI: 10.1016/j.freeradbiomed.2016.10.528.Peer-Reviewed Original ResearchHigh-fat dietHouse dust miteNasal epithelial cellsLung tissueMurine lung tissueWhole lung tissueReactive oxygen speciesEpithelial cellsPrimary nasal epithelial cellsPoor symptom controlHuman nasal epithelial cellsNon-asthmatic patientsPathophysiology of asthmaMajor risk factorFrequent exacerbationsObese asthmaticsSymptom controlComorbid diseasesObese controlsPulmonary diseaseC57BL/6 miceLung diseaseDust miteRisk factorsWestern diet
2015
Anti-Inflammatory Effects of Levalbuterol-Induced 11β-Hydroxysteroid Dehydrogenase Type 1 Activity in Airway Epithelial Cells
Randall MJ, Kostin SF, Burgess EJ, Hoyt LR, Ather JL, Lundblad LK, Poynter ME. Anti-Inflammatory Effects of Levalbuterol-Induced 11β-Hydroxysteroid Dehydrogenase Type 1 Activity in Airway Epithelial Cells. Frontiers In Endocrinology 2015, 5: 236. PMID: 25628603, PMCID: PMC4290686, DOI: 10.3389/fendo.2014.00236.Peer-Reviewed Original ResearchAirway epithelial cellsPro-inflammatory cytokine productionNF-κB activationAsthmatic subjectsCytokine productionRacemic albuterolEpithelial cellsEpithelial NF-κB activationAnti-inflammatory effectsNF-κB transcriptional activityTumor necrosis factorType 1 activityNF-κB activityAirway inflammationAllergic asthmaEndogenous glucocorticoidsLung functionCombination therapyNecrosis factorCorticosteroidsLuc activityAugments expressionAlbuterolMouse modelNF-κB