2021
Oral anaphylaxis to peanut in a mouse model is associated with gut permeability but not with Tlr4 or Dock8 mutations
Gertie JA, Zhang B, Liu EG, Hoyt LR, Yin X, Xu L, Long LL, Soldatenko A, Gowthaman U, Williams A, Eisenbarth SC. Oral anaphylaxis to peanut in a mouse model is associated with gut permeability but not with Tlr4 or Dock8 mutations. Journal Of Allergy And Clinical Immunology 2021, 149: 262-274. PMID: 34051223, PMCID: PMC8626534, DOI: 10.1016/j.jaci.2021.05.015.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAnimalsArachisDisease Models, AnimalFemaleGastrointestinal MicrobiomeGenetic Predisposition to DiseaseGuanine Nucleotide Exchange FactorsIntestinal MucosaMaleMice, Inbred C3HMice, Inbred C57BLMutationPassive Cutaneous AnaphylaxisPeanut HypersensitivityPermeabilitySpecies SpecificityToll-Like Receptor 4ConceptsC3H/HeJ miceGut permeabilityHeJ miceOral anaphylaxisPeanut challengeFood allergyMouse modelToll-like receptor 4BALB/c miceCytokinesis 8 (DOCK8) mutationsEnhanced gut permeabilityOral peanut challengesDOCK8 functionIngested allergenImmunologic mechanismsAnaphylaxis responsesImmunologic pathwaysAllergic diseasesC57BL/6 micePeanut allergyAntibody responseC miceReceptor 4DOCK8 mutationsIntraperitoneal challenge
2016
465 Protein S-Acylation in Pulmonary Disease
Randall M, Ather J, Hoyt L, Dixon A, Poynter M. 465 Protein S-Acylation in Pulmonary Disease. Free Radical Biology And Medicine 2016, 100: s193. DOI: 10.1016/j.freeradbiomed.2016.10.528.Peer-Reviewed Original ResearchHigh-fat dietHouse dust miteNasal epithelial cellsLung tissueMurine lung tissueWhole lung tissueReactive oxygen speciesEpithelial cellsPrimary nasal epithelial cellsPoor symptom controlHuman nasal epithelial cellsNon-asthmatic patientsPathophysiology of asthmaMajor risk factorFrequent exacerbationsObese asthmaticsSymptom controlComorbid diseasesObese controlsPulmonary diseaseC57BL/6 miceLung diseaseDust miteRisk factorsWestern diet