2016
Downregulation of ST6GALNAC1 is associated with esophageal squamous cell carcinoma development
Iwaya T, Sawada G, Amano S, Kume K, Ito C, Endo F, Konosu M, Shioi Y, Akiyama Y, Takahara T, Otsuka K, Nitta H, Koeda K, Mizuno M, Nishizuka S, Sasaki A, Mimori K. Downregulation of ST6GALNAC1 is associated with esophageal squamous cell carcinoma development. International Journal Of Oncology 2016, 50: 441-447. PMID: 28035351, DOI: 10.3892/ijo.2016.3817.Peer-Reviewed Original ResearchMeSH KeywordsAgedCarcinogenesisCarcinoma, Squamous CellChromosomes, Human, Pair 17Down-RegulationEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansLoss of HeterozygosityMaleReal-Time Polymerase Chain ReactionSialyltransferasesTranscriptomeConceptsQuantitative real-time reverse transcription PCRSporadic esophageal squamous cell carcinomasResponsible geneRNA sequence analysisClinical ESCC samplesPutative tumor suppressor geneCell linesTumor suppressor geneChromosome 17q25.1Esophageal squamous cell carcinoma (ESCC) developmentReal-time reverse transcription PCREsophageal squamous cell carcinomaMultiple genesCandidate genesExpression patternsChromosome 17q25Reverse transcription-PCRSequence analysisSuppressor geneGenesMethylation analysisCorresponding normal tissuesST6GALNAC1Transcription-PCRESCC developmentDuctular reactions in the liver regeneration process with local inflammation after physical partial hepatectomy
Suzuki Y, Katagiri H, Wang T, Kakisaka K, Kume K, Nishizuka SS, Takikawa Y. Ductular reactions in the liver regeneration process with local inflammation after physical partial hepatectomy. Laboratory Investigation 2016, 96: 1211-1222. PMID: 27617400, DOI: 10.1038/labinvest.2016.97.Peer-Reviewed Original ResearchConceptsLiver regeneration processDuctular reactionMurine liver injury modelsLocal inflammatory responseLiver injury modelExtracellular matrix-associated genesPartial hepatectomy modelMatrix-associated genesStem/progenitor cellsLiver stem/progenitor cellsTissue repair processLiver regeneration studiesSystematic remodelingExtracellular matrix remodelingLeft lobeInflammatory cytokinesLocal inflammationLiver weightHepatocyte hypertrophyInflammatory responseInjury modelLocal injuryKi67 stainingSurgical proceduresEntire liver
2014
A Compensatory Role of NF-κB to p53 in Response to 5-FU–Based Chemotherapy for Gastric Cancer Cell Lines
Endo F, Nishizuka SS, Kume K, Ishida K, Katagiri H, Ishida K, Sato K, Iwaya T, Koeda K, Wakabayashi G. A Compensatory Role of NF-κB to p53 in Response to 5-FU–Based Chemotherapy for Gastric Cancer Cell Lines. PLOS ONE 2014, 9: e90155. PMID: 24587255, PMCID: PMC3937424, DOI: 10.1371/journal.pone.0090155.Peer-Reviewed Original ResearchMeSH KeywordsAntimetabolites, AntineoplasticCell Line, TumorCodonDrug Resistance, NeoplasmFluorouracilGene Expression ProfilingGene Expression Regulation, NeoplasticGene Knockdown TechniquesHumansNF-kappa BProtein BindingProtein TransportStomach NeoplasmsTranscription Factor RelATumor Suppressor Protein p53ConceptsGastric cancer cell linesCancer cell linesNF-κBAdjuvant chemotherapyPrediction markersCell linesNF-κB-dependent mannerGastric cancer patientsKnockdown of RelANF-κB bindingArg homozygosityCurative resectionRelapse rateCancer patientsGastric cancerPrediction biomarkersChemotherapyP65 subunitTP53 knockdownChemotherapeutic efficacyProtein levelsCompensatory roleP53Target protein levelsTreatment