2024
Sleep Deficiency and Opioid Use Disorder Trajectory, Mechanisms, and Interventions
Langstengel J, Yaggi H. Sleep Deficiency and Opioid Use Disorder Trajectory, Mechanisms, and Interventions. Sleep Medicine Clinics 2024, 19: 625-638. PMID: 39455182, DOI: 10.1016/j.jsmc.2024.07.009.Peer-Reviewed Original ResearchConceptsOpioid use disorderRelapsing brain diseaseSleep deficiencyLoss of controlOpioid usePain perceptionUse disorderMultiple potential causesCognitive functionPoor sleep qualitySleep disordersAutonomic activityTherapeutic targetDisrupted sleepCircadian disruptionOpioidSleep qualityBrain diseasesPotential causesDisordersSleepDeficiencyBidirectional mechanismPainPatientsArousal threshold modifies the effect of CPAP on executive function among individuals with obstructive sleep apnea.
Zinchuk A, Kushida C, Walker A, Wellman A, Azarbarzin A, Alex R, Varga A, Sands S, Yaggi H. Arousal threshold modifies the effect of CPAP on executive function among individuals with obstructive sleep apnea. European Respiratory Journal 2024, 2401183. PMID: 39572221, DOI: 10.1183/13993003.01183-2024.Peer-Reviewed Original ResearchEffect of continuous positive airway pressureContinuous positive airway pressureObstructive sleep apneaSleep apneaArousal thresholdApnea Positive Pressure Long-term Efficacy StudySham continuous positive airway pressureEffect of CPAP treatmentPositive airway pressureLong-term efficacy studiesAssociated with neurocognitive dysfunctionCPAP treatmentAirway pressureSham-controlled trialApneaRandomized trialsSecondary outcomesNeurocognitive dysfunctionNeurocognitive outcomesTotal timeEfficacy studiesNeurocognitive functionSecondary analysisArTHExecutive functionThe Great Controversy of Obstructive Sleep Apnea Treatment for Cardiovascular Risk Benefit: Advancing the Science Through Expert Consensus. An Official American Thoracic Society Workshop Report.
Cohen O, Kundel V, Barbé F, Peker Y, McEvoy D, Sánchez-de-la-Torre M, Gottlieb D, Bradley T, Suárez-Fariñas M, Zinchuk A, Azarbarzin A, Malhotra A, Schotland H, Gozal D, Jelic S, Ramos A, Martin J, Pamidi S, Johnson D, Mehra R, Somers V, Hoyos C, Jackson C, Alcantara C, Billings M, Bhatt D, Patel S, Redline S, Yaggi H, Shah N. The Great Controversy of Obstructive Sleep Apnea Treatment for Cardiovascular Risk Benefit: Advancing the Science Through Expert Consensus. An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2024 PMID: 39513996, DOI: 10.1513/annalsats.202409-981st.Peer-Reviewed Original ResearchObstructive sleep apneaPositive airway pressureRandomized controlled trialsCardiovascular diseaseImpact of obstructive sleep apneaPrevalence of obstructive sleep apneaOSA subtypesSubgroup of OSA patientsObstructive sleep apnea syndromeObstructive sleep apnea treatmentIncidence of comorbid conditionsSleep apnea treatmentCardiovascular risk benefitMulti-modality therapeutic approachSleep clinic patientsPersonalized therapeutic strategiesTreat symptomatic patientsResponse to treatmentSecondary CVD eventsCost-effective diagnosisComposite CVD outcomeOSA patientsPAP adherenceSleep apneaAssessment of symptomsLessons about Low-Dose Morphine at the Intersection of Sleep and Breathlessness
Domnik N, Yaggi H. Lessons about Low-Dose Morphine at the Intersection of Sleep and Breathlessness. American Journal Of Respiratory And Critical Care Medicine 2024, 210: 1071-1073. PMID: 38843192, PMCID: PMC11544365, DOI: 10.1164/rccm.202404-0682ed.Peer-Reviewed Original ResearchAssociations Among Sleep, Pain, and Medications for Opioid Use Disorder: a Scoping Review
Hsaio C, DiMeola K, Jegede O, Funaro M, Langstengel J, Yaggi H, Barry D. Associations Among Sleep, Pain, and Medications for Opioid Use Disorder: a Scoping Review. Current Addiction Reports 2024, 1-17. DOI: 10.1007/s40429-024-00606-7.Peer-Reviewed Original ResearchOpioid use disorderOUD severityUse disorderTreatment characteristicsOpioid use disorder treatment settingsTreatment of sleepDosing scheduleDisorder severityOpioidPainWeb of ScienceAssessed patientsCochrane LibraryMeasures of sleepMOUD treatmentCurrent evidenceMOUDSleepSleep disturbanceProvider preferencesPatientsStudy examined sleepDisordersTreatment settingsMedicationThe connection between sleep deficiency and coronary artery disease: Complexities and controversies
Ujjawal A, Lobo T, Yaggi H, Neeland I. The connection between sleep deficiency and coronary artery disease: Complexities and controversies. Progress In Cardiovascular Diseases 2024 PMID: 39384126, DOI: 10.1016/j.pcad.2024.10.002.Peer-Reviewed Original ResearchCoronary artery diseaseArtery diseaseBurden of coronary artery diseaseRisk of coronary artery diseaseActivation of pro-inflammatory cytokinesPathophysiology of coronary artery diseasePro-inflammatory cytokinesSleep deficiencyAssociation of sleepPathophysiological mechanismsNovel treatmentSleep physiologyEtiological relationshipDisease processSleepDiseaseDeficiencyPhysiological phenomenaMorbidityCytokinesPathophysiologyNovel physiologic predictors of positive airway pressure effectiveness (NICEPAP) study: rationale, design and methods
Anwar A, Byrne S, Sharma A, Sands S, Wellman A, Redeker N, Yaggi H, Zinchuk A. Novel physiologic predictors of positive airway pressure effectiveness (NICEPAP) study: rationale, design and methods. Sleep And Breathing 2024, 28: 2005-2015. PMID: 38995327, DOI: 10.1007/s11325-024-03099-w.Peer-Reviewed Original ResearchObstructive sleep apneaPositive airway pressure effectObstructive sleep apnea traitsCPAP effectsCPAP adherencePrimary outcomePurposeContinuous positive airway pressureFunctional Outcomes of Sleep QuestionnaireEffects of CPAPPositive airway pressureAcademic sleep centerObservational cohort studyPrecision medicine approachCPAP dataCPAP efficacyBaseline polysomnographySleep apneaPrimary therapyAirway pressureSleep centerArousal thresholdPatient-centered outcomesPharyngeal collapseSleep qualityCPAPLinks Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes
Aneni E, Sinusas A, Emokpae M, Thorn S, Yaggi H, Miller E. Links Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes. Current Cardiology Reports 2024, 26: 723-734. PMID: 38806976, DOI: 10.1007/s11886-024-02072-z.Peer-Reviewed Original ResearchObstructive sleep apneaCoronary microvascular dysfunctionAbnormal myocardial blood flowSevere obstructive sleep apneaMyocardial flow reserveMyocardial blood flowSleep apneaModerate to severe obstructive sleep apneaAbnormal myocardial flow reserveRecent FindingsRecent studiesDisease-related outcomesBlood flow changesMyocardial blood flow changesCardiovascular disease-related outcomesMicrovascular dysfunctionClinical impactCPAPReviewRecent studiesStructural abnormalitiesCoronary microcirculationFindingsRecent studiesFlow reserveCardiac workBlood flowApneaInvestigating Brain State Engagement Variability in Individuals With Opioid Use Disorder Using Naturalistic and Task-Based fMRI Data
Ye J, Mehta S, Peterson H, Ibrahim A, Saeed G, Linsky S, Kreinin I, Tsang S, Nwanaji-Enwerem U, Raso A, Yip S, Tokoglu F, Arora J, Constable R, Barry D, Redeker N, Yaggi H, Scheinost D. Investigating Brain State Engagement Variability in Individuals With Opioid Use Disorder Using Naturalistic and Task-Based fMRI Data. Biological Psychiatry 2024, 95: s6. DOI: 10.1016/j.biopsych.2024.02.022.Peer-Reviewed Original Research1. Multimodal Neuroimaging Findings in Individuals With Opioid Use Disorder
Mehta S, Peterson H, Ibrahim A, Saeed G, Linsky S, Kreinin I, Tsang S, Nwanaji-Enwerem U, Raso A, Arora J, Tokoglu F, Hahn C, Lacadie C, Greene A, Constable T, Barry D, Redeker N, Yaggi H, Scheinost D. 1. Multimodal Neuroimaging Findings in Individuals With Opioid Use Disorder. Biological Psychiatry 2024, 95: s99. DOI: 10.1016/j.biopsych.2024.02.236.Peer-Reviewed Original ResearchSalty, Sweet, and Severe: A Case of Linagliptin-induced Severe Hyponatremia
Renzetti M, Potnis K, Vemmou E, Hansen B, Lin D, Yaggi H. Salty, Sweet, and Severe: A Case of Linagliptin-induced Severe Hyponatremia. 2024, a7036-a7036. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a7036.Peer-Reviewed Original ResearchScreen time, sleep, brain structural neurobiology, and sequential associations with child and adolescent psychopathology: Insights from the ABCD study
Zhao Y, Paulus M, Tapert S, Bagot K, Constable R, Yaggi H, Redeker N, Potenza M. Screen time, sleep, brain structural neurobiology, and sequential associations with child and adolescent psychopathology: Insights from the ABCD study. Journal Of Behavioral Addictions 2024, 13: 542-553. PMID: 38662452, PMCID: PMC11220810, DOI: 10.1556/2006.2024.00016.Peer-Reviewed Original ResearchCross-lagged panel modelScreen media activitySleep problemsExternalizing symptomsAdolescent Brain Cognitive Development StudyLate childhoodCognitive Development StudyPredicted sleep problemsSleep durationAssociated with childrenAdolescent psychopathologyPsychopathological symptomsInternalizing symptomsExternalizing behaviorsPsychopathologyABCD studyStructural covarianceBidirectional associationsSleep concernsPredictive relationshipSleep disturbanceShort sleep durationPanel modelBrain covariesSleep0230 Comparing Subjective and Objective Measures of Chronotypes and Their Associations with Age in Older Adults
Pan Y, Cho G, Burzynski C, Polisetty L, Doyle M, Iannone L, Knauert M, Yaggi H, Gill T, Miner B. 0230 Comparing Subjective and Objective Measures of Chronotypes and Their Associations with Age in Older Adults. Sleep 2024, 47: a99-a99. DOI: 10.1093/sleep/zsae067.0230.Peer-Reviewed Original ResearchOlder adultsAssociated with ageCommunity-living older adultsSleep midpointSeven-daySelf-reported sleep complaintsDays of actigraphyChi-square testTwo-sample t-testActivity countsNo significant differencePearson correlation coefficientAdverse outcomesCT groupMinority raceVariability of chronotypeAdvanced ageObservational studyMorningness-Eveningness QuestionnaireMeasures of chronotypeDemographic factorsSleep onsetModerate correlationSleep disturbanceSignificant difference0309 Concordance in Electroencephalography-Headband versus Polysomnography by Demographics and Cognitive Status
Miner B, Pan Y, Cho G, Burzynski C, Polisetty L, Doyle M, Iannone L, Knauert M, Gill T, Yaggi H. 0309 Concordance in Electroencephalography-Headband versus Polysomnography by Demographics and Cognitive Status. Sleep 2024, 47: a133-a133. DOI: 10.1093/sleep/zsae067.0309.Peer-Reviewed Original ResearchTotal sleep timeIntraclass correlation coefficientMeasure total sleep timeMild cognitive impairmentCognitive statusSleep complaintsNight of home-based polysomnographyHome-based polysomnographySelf-reported sleep complaintsCommunity-living older adultsBetween-group differencesPaired t-testPresence of mild cognitive impairmentExcellent concordanceSleep timeAcceptable alternativeWASOPolysomnographyReduced concordancePSGSleep disturbanceOlder personsOlder adultsPeople of colorWomen0757 Association of Insomnia with Objective Short Sleep Duration and Other Phenotypes with Mortality in Older Persons
Miner B, Pan Y, Cho G, Knauert M, Yaggi H, Gill T, Stone K, Ensrud K, Zeitzer J, Yaffe K, Doyle M. 0757 Association of Insomnia with Objective Short Sleep Duration and Other Phenotypes with Mortality in Older Persons. Sleep 2024, 47: a324-a325. DOI: 10.1093/sleep/zsae067.0757.Peer-Reviewed Original ResearchAssociated with increased mortality riskAssociation of insomniaMortality riskOlder personsShort sleep durationOsteoporotic fracturesAdjusted modelsStudy of Osteoporotic FracturesSleep durationHigher mortality riskCox proportional hazards modelsMen Sleep StudyNormal sleepProportional hazards modelAssociated with mortalitySevere sleep-disordered breathingUnadjusted modelsUnadjusted analysisCausal pathwaysSleep-disordered breathingFollow-up timePrevalence ratesReference groupHazards modelRisk phenotypes0680 Body Clock and Aging: Relationships of Circadian Rhythm with Sleep Quality, Mental Health and Geriatric Conditions
Adirim Z, Pan Y, Doyle M, Knauert M, Yaggi H, Miner B. 0680 Body Clock and Aging: Relationships of Circadian Rhythm with Sleep Quality, Mental Health and Geriatric Conditions. Sleep 2024, 47: a291-a291. DOI: 10.1093/sleep/zsae067.0680.Peer-Reviewed Original ResearchOlder adult populationMental healthGeriatric conditionsSleep midpointSleep qualityAssociated with cognitive dysfunctionOlder adultsAdult populationAssociated with mental health diagnosesCommunity-dwelling older adultsAssociated with lower cognitive scoresMental health diagnosesAssociated with sleep qualityMental health conditionsSubjective sleep qualityReduced total sleep timeLower cognitive scoresCross-sectional studyGeneral adult populationPsychiatric symptomsTotal sleep timeSelf-reported sleep complaintsCognitive dysfunctionCircadian rhythmLater sleep midpoint0495 Association of Cannabis Use and Symptoms Among Patients with Obstructive Sleep Apnea
Inaya A, Baldassarri S, Sands S, Yaggi H, Wellman A, Redeker N, Zinchuk A. 0495 Association of Cannabis Use and Symptoms Among Patients with Obstructive Sleep Apnea. Sleep 2024, 47: a213-a213. DOI: 10.1093/sleep/zsae067.0495.Peer-Reviewed Original ResearchAssociation of cannabis useCannabis useSleep latencyCannabis usersParticipants self-reported cannabis useLong-term cannabis useLong-term effects of cannabisSelf-reported cannabis useHigh prevalence of painObstructive sleep apneaEffects of cannabisPrevalence of painHigher consumption of alcoholProportion of painNo differenceUsers of cannabisSymptoms of painMann-Whitney U testIncreased sleep latencySleep durationRegular alcohol useSlow wave sleepCPAP effectsOSA severityOSA symptoms0488 Exploring Study Recruitment Trends in the Acute Post-Stroke Setting
Schwarz J, Masroor K, Radulescu R, Tsang S, Sheth K, Redeker N, Yaggi H, Geer J. 0488 Exploring Study Recruitment Trends in the Acute Post-Stroke Setting. Sleep 2024, 47: a210-a210. DOI: 10.1093/sleep/zsae067.0488.Peer-Reviewed Original ResearchContinuous positive airway pressureObstructive sleep apneaPositive airway pressureAcute ischemic strokeAirway pressureUpper airway closureSleep-disordered breathingYale-New Haven HospitalCerebral blood flowOSA screeningOSA treatmentSleep apneaImpact cerebral blood flowAcademic medical centerSympathetic activityClinical trialsPatient populationHemodynamic changesRisk factorsPatientsFunctional recoveryExclusion criteriaAirway closureCardiovascular diseaseBlood flow0486 Performing Polysomnography in the Acute Post-stroke Setting
Masroor K, Schwarz J, Radulescu R, Tsang S, Sheth K, Redeker N, Yaggi H, Geer J. 0486 Performing Polysomnography in the Acute Post-stroke Setting. Sleep 2024, 47: a209-a209. DOI: 10.1093/sleep/zsae067.0486.Peer-Reviewed Original ResearchObstructive sleep apneaSleep apneaRates of obstructive sleep apneaSymptoms of obstructive sleep apneaSevere obstructive sleep apneaObstructive sleep apnea diagnosisAcute settingSleep-disordered breathingPercentage of patientsProportion of patientsYale-New Haven HospitalAHI cutoffOSA prevalenceOSA diagnosisPreventing recurrent strokeImprove stroke recoveryPolysomnography testNew Haven HospitalPolysomnographyScreening patientsTherapeutic windowApneaPatientsRisk factorsMedical recordsArousal threshold modifies the effects of CPAP therapy on neurocognition in men and women in the APPLES study
Zinchuk A, Walker A, Kushida C, Wellman A, Yaggi H, Sands S. Arousal threshold modifies the effects of CPAP therapy on neurocognition in men and women in the APPLES study. Sleep Medicine 2024, 115: 324-325. DOI: 10.1016/j.sleep.2023.11.876.Peer-Reviewed Original Research