2024
Arousal threshold modifies the effect of CPAP on executive function among individuals with obstructive sleep apnea.
Zinchuk A, Kushida C, Walker A, Wellman A, Azarbarzin A, Alex R, Varga A, Sands S, Yaggi H. Arousal threshold modifies the effect of CPAP on executive function among individuals with obstructive sleep apnea. European Respiratory Journal 2024, 2401183. PMID: 39572221, DOI: 10.1183/13993003.01183-2024.Peer-Reviewed Original ResearchEffect of continuous positive airway pressureContinuous positive airway pressureObstructive sleep apneaSleep apneaArousal thresholdApnea Positive Pressure Long-term Efficacy StudySham continuous positive airway pressureEffect of CPAP treatmentPositive airway pressureLong-term efficacy studiesAssociated with neurocognitive dysfunctionCPAP treatmentAirway pressureSham-controlled trialApneaRandomized trialsSecondary outcomesNeurocognitive dysfunctionNeurocognitive outcomesTotal timeEfficacy studiesNeurocognitive functionSecondary analysisArTHExecutive functionThe Great Controversy of Obstructive Sleep Apnea Treatment for Cardiovascular Risk Benefit: Advancing the Science Through Expert Consensus. An Official American Thoracic Society Workshop Report.
Cohen O, Kundel V, Barbé F, Peker Y, McEvoy D, Sánchez-de-la-Torre M, Gottlieb D, Bradley T, Suárez-Fariñas M, Zinchuk A, Azarbarzin A, Malhotra A, Schotland H, Gozal D, Jelic S, Ramos A, Martin J, Pamidi S, Johnson D, Mehra R, Somers V, Hoyos C, Jackson C, Alcantara C, Billings M, Bhatt D, Patel S, Redline S, Yaggi H, Shah N. The Great Controversy of Obstructive Sleep Apnea Treatment for Cardiovascular Risk Benefit: Advancing the Science Through Expert Consensus. An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2024 PMID: 39513996, DOI: 10.1513/annalsats.202409-981st.Peer-Reviewed Original ResearchObstructive sleep apneaPositive airway pressureRandomized controlled trialsCardiovascular diseaseImpact of obstructive sleep apneaPrevalence of obstructive sleep apneaOSA subtypesSubgroup of OSA patientsObstructive sleep apnea syndromeObstructive sleep apnea treatmentIncidence of comorbid conditionsSleep apnea treatmentCardiovascular risk benefitMulti-modality therapeutic approachSleep clinic patientsPersonalized therapeutic strategiesTreat symptomatic patientsResponse to treatmentSecondary CVD eventsCost-effective diagnosisComposite CVD outcomeOSA patientsPAP adherenceSleep apneaAssessment of symptomsNovel physiologic predictors of positive airway pressure effectiveness (NICEPAP) study: rationale, design and methods
Anwar A, Byrne S, Sharma A, Sands S, Wellman A, Redeker N, Yaggi H, Zinchuk A. Novel physiologic predictors of positive airway pressure effectiveness (NICEPAP) study: rationale, design and methods. Sleep And Breathing 2024, 28: 2005-2015. PMID: 38995327, DOI: 10.1007/s11325-024-03099-w.Peer-Reviewed Original ResearchObstructive sleep apneaPositive airway pressure effectObstructive sleep apnea traitsCPAP effectsCPAP adherencePrimary outcomePurposeContinuous positive airway pressureFunctional Outcomes of Sleep QuestionnaireEffects of CPAPPositive airway pressureAcademic sleep centerObservational cohort studyPrecision medicine approachCPAP dataCPAP efficacyBaseline polysomnographySleep apneaPrimary therapyAirway pressureSleep centerArousal thresholdPatient-centered outcomesPharyngeal collapseSleep qualityCPAPLinks Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes
Aneni E, Sinusas A, Emokpae M, Thorn S, Yaggi H, Miller E. Links Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes. Current Cardiology Reports 2024, 26: 723-734. PMID: 38806976, DOI: 10.1007/s11886-024-02072-z.Peer-Reviewed Original ResearchObstructive sleep apneaCoronary microvascular dysfunctionAbnormal myocardial blood flowSevere obstructive sleep apneaMyocardial flow reserveMyocardial blood flowSleep apneaModerate to severe obstructive sleep apneaAbnormal myocardial flow reserveRecent FindingsRecent studiesDisease-related outcomesBlood flow changesMyocardial blood flow changesCardiovascular disease-related outcomesMicrovascular dysfunctionClinical impactCPAPReviewRecent studiesStructural abnormalitiesCoronary microcirculationFindingsRecent studiesFlow reserveCardiac workBlood flowApnea0495 Association of Cannabis Use and Symptoms Among Patients with Obstructive Sleep Apnea
Inaya A, Baldassarri S, Sands S, Yaggi H, Wellman A, Redeker N, Zinchuk A. 0495 Association of Cannabis Use and Symptoms Among Patients with Obstructive Sleep Apnea. Sleep 2024, 47: a213-a213. DOI: 10.1093/sleep/zsae067.0495.Peer-Reviewed Original ResearchAssociation of cannabis useCannabis useSleep latencyCannabis usersParticipants self-reported cannabis useLong-term cannabis useLong-term effects of cannabisSelf-reported cannabis useHigh prevalence of painObstructive sleep apneaEffects of cannabisPrevalence of painHigher consumption of alcoholProportion of painNo differenceUsers of cannabisSymptoms of painMann-Whitney U testIncreased sleep latencySleep durationRegular alcohol useSlow wave sleepCPAP effectsOSA severityOSA symptoms0488 Exploring Study Recruitment Trends in the Acute Post-Stroke Setting
Schwarz J, Masroor K, Radulescu R, Tsang S, Sheth K, Redeker N, Yaggi H, Geer J. 0488 Exploring Study Recruitment Trends in the Acute Post-Stroke Setting. Sleep 2024, 47: a210-a210. DOI: 10.1093/sleep/zsae067.0488.Peer-Reviewed Original ResearchContinuous positive airway pressureObstructive sleep apneaPositive airway pressureAcute ischemic strokeAirway pressureUpper airway closureSleep-disordered breathingYale-New Haven HospitalCerebral blood flowOSA screeningOSA treatmentSleep apneaImpact cerebral blood flowAcademic medical centerSympathetic activityClinical trialsPatient populationHemodynamic changesRisk factorsPatientsFunctional recoveryExclusion criteriaAirway closureCardiovascular diseaseBlood flow0486 Performing Polysomnography in the Acute Post-stroke Setting
Masroor K, Schwarz J, Radulescu R, Tsang S, Sheth K, Redeker N, Yaggi H, Geer J. 0486 Performing Polysomnography in the Acute Post-stroke Setting. Sleep 2024, 47: a209-a209. DOI: 10.1093/sleep/zsae067.0486.Peer-Reviewed Original ResearchObstructive sleep apneaSleep apneaRates of obstructive sleep apneaSymptoms of obstructive sleep apneaSevere obstructive sleep apneaObstructive sleep apnea diagnosisAcute settingSleep-disordered breathingPercentage of patientsProportion of patientsYale-New Haven HospitalAHI cutoffOSA prevalenceOSA diagnosisPreventing recurrent strokeImprove stroke recoveryPolysomnography testNew Haven HospitalPolysomnographyScreening patientsTherapeutic windowApneaPatientsRisk factorsMedical recordsAssociation of Periodic Limb Movements and Obstructive Sleep Apnea With Risk of Cardiovascular Disease and Mortality
Zinchuk A, Srivali N, Qin L, Jeon S, Ibrahim A, Sands S, Koo B, Yaggi H. Association of Periodic Limb Movements and Obstructive Sleep Apnea With Risk of Cardiovascular Disease and Mortality. Journal Of The American Heart Association 2024, 13: e031630. PMID: 38240208, PMCID: PMC11056155, DOI: 10.1161/jaha.123.031630.Peer-Reviewed Original ResearchConceptsPeriodic limb movement indexApnea-hypopnea indexObstructive sleep apneaPeriodic limb movementsSleep apneaIncident cardiovascular diseasePrimary outcomeCardiovascular diseaseAssociation of apnea-hypopnea indexIncreased risk of primary outcomeIncreased riskRisk factorsRisk of primary outcomeAssociated with primary outcomeMedian follow-upBaseline risk of mortalityCox proportional hazards regressionRisk of cardiovascular diseaseLimb movement indexCharlson Comorbidity IndexFramingham risk scoreProportional hazards regressionRisk of mortalityCardiovascular disease eventsFollow-up
2023
Insomnia and Early Incident Atrial Fibrillation: A 16‐Year Cohort Study of Younger Men and Women Veterans
Gaffey A, Rosman L, Lampert R, Yaggi H, Haskell S, Brandt C, Enriquez A, Mazzella A, Skanderson M, Burg M. Insomnia and Early Incident Atrial Fibrillation: A 16‐Year Cohort Study of Younger Men and Women Veterans. Journal Of The American Heart Association 2023, 12: e030331. PMID: 37791503, PMCID: PMC10757545, DOI: 10.1161/jaha.123.030331.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaIncident atrial fibrillationAtrial fibrillationHealth care utilizationSleep apneaAF onsetCohort studyCare utilizationAF riskMultivariate Cox proportional hazards modelVeterans Health Administration (VHA) careRisk of AFCox proportional hazards modelCases of AFEarly cardiovascular riskIncident AF riskAssociation of insomniaProportional hazards modelCommon sleep disorderPost-9/11 veteransElectronic health recordsAF incidenceCardiovascular riskClinical comorbiditiesLifestyle factorsEXCESSIVE DAYTIME SLEEPINESS IS ASSOCIATED WITH INCIDENT HEART FAILURE IN A CLINICAL POPULATION WITH OBSTRUCTIVE SLEEP APNEA
SAEED G, OGUNMOLA I, OTITE F, LAMIKANRA O, OSONDU C, MEZUE K, FEHER A, YAGGI H, ANENI E. EXCESSIVE DAYTIME SLEEPINESS IS ASSOCIATED WITH INCIDENT HEART FAILURE IN A CLINICAL POPULATION WITH OBSTRUCTIVE SLEEP APNEA. CHEST Journal 2023, 164: a6312. DOI: 10.1016/j.chest.2023.07.4065.Peer-Reviewed Original ResearchSex‐Specific Associations of Obstructive Sleep Apnea Risk With Patient Characteristics and Functional Outcomes After Acute Myocardial Infarction: Evidence From the VIRGO Study
Gupta A, Barthel A, Mahajan S, Dreyer R, Yaggi H, Bueno H, Lichtman J, Krumholz H. Sex‐Specific Associations of Obstructive Sleep Apnea Risk With Patient Characteristics and Functional Outcomes After Acute Myocardial Infarction: Evidence From the VIRGO Study. Journal Of The American Heart Association 2023, 12: e027225. PMID: 37702090, PMCID: PMC10547292, DOI: 10.1161/jaha.122.027225.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaAcute myocardial infarctionHigh OSA riskOSA riskSex-specific associationsFunctional outcomeHealth statusHigh riskVIRGO StudyMyocardial infarctionDepressive symptomsHistory of OSATime of AMIImpact of OSAObstructive sleep apnea riskLow-risk patientsSleep apnea riskMajority of patientsTime of presentationSex-specific outcomesWorse health statusHigh-risk menPoor health statusMental health statusPoor health outcomesMorning Chronotype Is Associated with Improved Adherence to Continuous Positive Airway Pressure among Individuals with Obstructive Sleep Apnea.
Knauert M, Adekolu O, Xu Z, Deng A, Chu J, Baldassarri S, Kushida C, Yaggi H, Zinchuk A. Morning Chronotype Is Associated with Improved Adherence to Continuous Positive Airway Pressure among Individuals with Obstructive Sleep Apnea. Annals Of The American Thoracic Society 2023, 20: 1182-1191. PMID: 36917194, PMCID: PMC10405611, DOI: 10.1513/annalsats.202210-885oc.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaCPAP adherenceMorning chronotypeCPAP useSleep apneaClinical trialsMorningness-Eveningness QuestionnaireSleep durationContinuous positive airway pressure therapyPositive airway pressure therapyContinuous positive airway pressureSevere obstructive sleep apneaChronotype of patientsDaily CPAP useAirway pressure therapyPositive airway pressureShort sleep durationCPAP armAirway pressureObese menPressure therapyPoor adherenceWeekend catchAdherence dataEvening chronotype0480 Psychoactive Substance Use and Sleep Characteristics Among Individuals with Untreated Obstructive Sleep Apnea
Walker A, Baldassarri S, Chu J, Deng A, Xu Z, Blohowiak R, Byrne S, Kushida C, Yaggi H, Zinchuk A. 0480 Psychoactive Substance Use and Sleep Characteristics Among Individuals with Untreated Obstructive Sleep Apnea. Sleep 2023, 46: a213-a214. DOI: 10.1093/sleep/zsad077.0480.Peer-Reviewed Original ResearchObstructive sleep apneaUntreated obstructive sleep apneaApnea Positive Pressure Long-term Efficacy StudyPsychoactive substance useDaytime symptomsSleep architectureSubstance useSleep characteristicsSleep durationIntroduction Obstructive sleep apneaCaffeine useModerate caffeine useNormal sleep architectureLong-term Efficacy StudyCo-morbid conditionsCurrent cigarette smokersShort sleep durationRecurrent airway obstructionLonger sleep latencyLower sleep durationHeavy alcohol usersObjective sleep characteristicsHeavy alcohol useCross-sectional analysisAirway obstructionNicotine, alcohol, and caffeine use among individuals with untreated obstructive sleep apnea
Baldassarri S, Chu J, Deng A, Xu Z, Blohowiak R, Byrne S, Kushida C, Yaggi H, Zinchuk A. Nicotine, alcohol, and caffeine use among individuals with untreated obstructive sleep apnea. Sleep And Breathing 2023, 27: 2479-2490. PMID: 37058215, PMCID: PMC10576010, DOI: 10.1007/s11325-023-02830-3.Peer-Reviewed Original ResearchConceptsUntreated obstructive sleep apneaObstructive sleep apneaApnea Positive Pressure Long-term Efficacy StudySubstance useDaytime symptomsSleep characteristicsSleep durationCaffeine useModerate caffeine useLong-term Efficacy StudyCurrent cigarette smokersHeavy caffeine usersObjective sleep characteristicsShort sleep durationModerate alcohol useMore REM sleepLower sleep durationHeavy alcohol usersCross-sectional analysisPsychoactive substance useCurrent smokersCurrent smokingComorbid conditionsMedian BMISleep apneaThe Association Between Obstructive Sleep Apnea and Abnormal 82Rubidium Cardiac PET Perfusion Myocardial Flow Reserve
Aneni E, Thorn S, Feher A, Hong Chen J, Sinusas A, Yaggi H, Miller E. The Association Between Obstructive Sleep Apnea and Abnormal 82Rubidium Cardiac PET Perfusion Myocardial Flow Reserve. JACC Cardiovascular Imaging 2023, 16: 856-858. PMID: 36881426, PMCID: PMC10718199, DOI: 10.1016/j.jcmg.2022.11.024.Peer-Reviewed Original ResearchSleep apnea and stroke
Geer J, Karagoz E, Yaggi H. Sleep apnea and stroke. 2023, 271-277. DOI: 10.1016/b978-0-12-822963-7.00325-x.Peer-Reviewed Original ResearchObstructive sleep apneaCerebrovascular diseaseRisk factorsImportant public health issueIndependent risk factorModifiable risk factorsMechanism of strokeSleep-disordered breathingPotential treatment modalityPublic health issueParadoxical embolismSystemic inflammationIntermittent hypoxiaSleep apneaSympathetic activationTreatment modalitiesLeading causeMetabolic dysfunctionStrokeHealth issuesApneaCurrent literatureDiseaseEmbolismAtherosclerosis
2022
0158 Risk perception, outcome expectancy, and treatment self-efficacy among women and men with obstructive sleep apnea (OSA)
Sharma A, Byrne S, Deng A, Chu J, Sands S, Wellman A, Redeke N, Yaggi H, Zinchuk A. 0158 Risk perception, outcome expectancy, and treatment self-efficacy among women and men with obstructive sleep apnea (OSA). Sleep 2022, 45: a73-a73. DOI: 10.1093/sleep/zsac079.156.Peer-Reviewed Original ResearchOutcome expectanciesContinuous positive airway pressureObstructive sleep apneaSub-scale scoresRisk perceptionSelf-efficacy measuresCPAP adherenceIndividual risk perceptionInsomnia Severity Index scoreCPAP therapyEffectiveness of CPAPNon-CPAP therapiesUnstable medical conditionsCo-primary outcomesFirst-line therapyPositive airway pressureApnea-hypopnea indexSeverity Index scoreEpworth Sleepiness ScalePerceptionSex differencesCPAP useOSA severityAirway pressureDaytime symptoms
2021
Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes: Results from the DREAM Study.
Ding Q, Qin L, Wojeck B, Inzucchi SE, Ibrahim A, Bravata DM, Strohl KP, Yaggi HK, Zinchuk AV. Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes: Results from the DREAM Study. Annals Of The American Thoracic Society 2021, 18: 2067-2078. PMID: 34185617, PMCID: PMC8641817, DOI: 10.1513/annalsats.202012-1556oc.Peer-Reviewed Original ResearchConceptsApnea-hypopnea indexObstructive sleep apneaPolysomnographic phenotypeIncident T2DMRisk of T2DMPredictive valueSleep apneaBlood glucoseRisk factorsCardiovascular diseaseMild obstructive sleep apneaIncident type 2 diabetesMultivariable-adjusted regression modelsCox proportional hazards regressionNew physician diagnosisT2DM risk predictionIncident cardiovascular diseaseIncident type 2Body mass indexProportional hazards regressionT2DM risk factorsBehavioral risk factorsType 2 diabetesMale veteran populationRisk regression modelsPrevalence of Obstructive Sleep Apnea in a Cohort of Veterans with Chronic Pain and Active Smoking History
Kunitomo Y, Lee M, DeRycke E, Yaggi H, Bastian L. Prevalence of Obstructive Sleep Apnea in a Cohort of Veterans with Chronic Pain and Active Smoking History. 2021, a1564-a1564. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1564.Peer-Reviewed Original ResearchAssociations Between Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes
Ding Q, Qin L, Wojeck B, Inzucchi S, Ibrahim A, Bravata D, Strohl K, Yaggi H, Zinchuk A. Associations Between Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes. 2021, a4679-a4679. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4679.Peer-Reviewed Original Research