2024
Reliability of dynamic causal modelling of resting‐state magnetoencephalography
Jafarian A, Assem M, Kocagoncu E, Lanskey J, Williams R, Cheng Y, Quinn A, Pitt J, Raymont V, Lowe S, Singh K, Woolrich M, Nobre A, Henson R, Friston K, Rowe J. Reliability of dynamic causal modelling of resting‐state magnetoencephalography. Human Brain Mapping 2024, 45: e26782. PMID: 38989630, PMCID: PMC11237883, DOI: 10.1002/hbm.26782.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlzheimer DiseaseBayes TheoremFemaleHumansMagnetoencephalographyMaleModels, NeurologicalReproducibility of Results
2022
New Therapeutics in Alzheimer’s Disease Longitudinal Cohort study (NTAD): study protocol
Lanskey J, Kocagoncu E, Quinn A, Cheng Y, Karadag M, Pitt J, Lowe S, Perkinton M, Raymont V, Singh K, Woolrich M, Nobre A, Henson R, Rowe J. New Therapeutics in Alzheimer’s Disease Longitudinal Cohort study (NTAD): study protocol. BMJ Open 2022, 12: e055135. PMID: 36521898, PMCID: PMC9756184, DOI: 10.1136/bmjopen-2021-055135.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentEarly-stage Alzheimer's diseaseCognitive impairmentPeer-reviewed scientific journalsLongitudinal cohort studyResearch Ethics CommitteeAlzheimer's diseaseAmyloid-positive mild cognitive impairmentAlzheimer's disease studyConference presentationsCohort studyMeasures of diseaseCognitive AssessmentDisease StudyStudy protocolPrimary analysisEthics CommitteeLongitudinal changesParticipantsCognitive changesWebsite publicationClinical trial durationNew therapeuticsEast of England-Cambridge Central Research Ethics CommitteeProgression of Alzheimer's disease
2020
Superior short-term memory in APOE ε2 carriers across the age range
Zokaei N, Board A, Slavkova E, Mackay C, Nobre A, Husain M. Superior short-term memory in APOE ε2 carriers across the age range. Behavioural Brain Research 2020, 397: 112918. PMID: 32961217, PMCID: PMC7732594, DOI: 10.1016/j.bbr.2020.112918.Peer-Reviewed Original ResearchConceptsShort-term memoryMemory advantageAssociated with individual differencesShort-term memory taskSignificant memory advantageAlzheimer's diseaseMemory performanceIndividual differencesTask difficultyAD-related pathologyAge rangeCognitive healthE3/E3 carriersSensitive to subtle changesAt-risk cohortElderly adultsApolipoprotein E4 alleleMemoryCognitionCohort of individualsMiddle-agedDevelopment of ADE4 alleleIndividualsPhenotypic effects
2018
Dissociable effects of the apolipoprotein-E (APOE) gene on short- and long-term memories
Zokaei N, Čepukaitytė G, Board A, Mackay C, Husain M, Nobre A. Dissociable effects of the apolipoprotein-E (APOE) gene on short- and long-term memories. Neurobiology Of Aging 2018, 73: 115-122. PMID: 30342272, PMCID: PMC6261846, DOI: 10.1016/j.neurobiolaging.2018.09.017.Peer-Reviewed Original ResearchConceptsLong-term memoryFunction of apolipoproteinsLong-term memory impairmentLong-term memory performanceMeasures of reportingPreclinical Alzheimer's diseasePhenotypic effectsMemory advantageNeural underpinningsItem identityMemory impairmentMemory performanceMeasure memoryShort-term memoryAlzheimer's diseaseDissociative effectsE4 alleleEffect of genotypeE4 carriersAllelesMemoryObject locationGenotypesApolipoproteinShort-APOE genotype and cognition in healthy individuals at risk of Alzheimer's disease: A review
O'Donoghue M, Murphy S, Zamboni G, Nobre A, Mackay C. APOE genotype and cognition in healthy individuals at risk of Alzheimer's disease: A review. Cortex 2018, 104: 103-123. PMID: 29800787, DOI: 10.1016/j.cortex.2018.03.025.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAnimalsApolipoprotein E4CognitionCognition DisordersCognitive DysfunctionHumansMemoryConceptsNeurobiological mechanismsCognitive deficitsAPOE-e4Sensitive measures of cognitionAPOE genotypeMeasures of cognitionNon-demented adultsAlzheimer's diseaseHealthy adultsCognitive agingInfluence of APOENeurobiological processesLiterature reporting effectsCognitive effectsInfluence cognitionCognitive consequencesBehavioral evidenceCognitive differencesRisk of Alzheimer's diseaseCognitionAPOE-e4 carriersDementia pathologyInfluence of APOE genotypeProdromal periodMid-adulthood
2016
Sex and APOE: A memory advantage in male APOE ε4 carriers in midlife
Zokaei N, Giehl K, Sillence A, Neville M, Karpe F, Nobre A, Husain M. Sex and APOE: A memory advantage in male APOE ε4 carriers in midlife. Cortex 2016, 88: 98-105. PMID: 28086184, PMCID: PMC5333781, DOI: 10.1016/j.cortex.2016.12.016.Peer-Reviewed Original ResearchConceptsMedial temporal lobeMisbinding errorsShort-term memoryDelayed estimation taskE4 carriersInteraction of genderMemory advantageInfluence of APOEMeasure memoryBehavioral advantageAntagonistic pleiotropy hypothesisTemporal lobeFeature bindingMemory decaySensitive tasksAPOE e4 carriersEstimation taskMemoryMisbindingPleiotropy hypothesisMiddle-aged individualsGene dosageMidlifeAPOE genotypeAPOE alleles