2024
Neural dynamics of shifting attention between perception and working-memory contents
Gresch D, Boettcher S, Gohil C, van Ede F, Nobre A. Neural dynamics of shifting attention between perception and working-memory contents. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2406061121. PMID: 39536078, PMCID: PMC11588118, DOI: 10.1073/pnas.2406061121.Peer-Reviewed Original ResearchConceptsAttention shiftsBrain activityNeural dynamicsPatterns of human brain activityWorking-memory taskWorking-memory contentsVisual contentInternal memory representationsWorking memoryMemory representationsSequential cuesHuman brain activityMultivariate decodingAlpha lateralizationSpatial attentionNeural statesCuesSensory environmentEveryday tasksTaskPerceptionCombined perceptionAttentionAlternative domainsMagnetoencephalographyA Neural Decision Signal during Internal Sampling from Working Memory in Humans
van Ede F, Nobre A. A Neural Decision Signal during Internal Sampling from Working Memory in Humans. Journal Of Neuroscience 2024, 44: e1475232024. PMID: 38538144, PMCID: PMC11079964, DOI: 10.1523/jneurosci.1475-23.2024.Peer-Reviewed Original ResearchConceptsWorking memoryDomains of working memoryMemory-guided behaviorEvolving decision processesInternal visual representationsNeural evidenceParietal positivitySensory evidenceMental contentMemory contentPurposeful behaviorDecision signalsTime participantsMemorySensory informationInternational sampleMultiple contentsDecision processVisual representationPsychologyDecision-making frameworkNeuroscienceEvidenceBehaviorParticipantsShifting attention between perception and working memory
Gresch D, Boettcher S, van Ede F, Nobre A. Shifting attention between perception and working memory. Cognition 2024, 245: 105731. PMID: 38278040, DOI: 10.1016/j.cognition.2024.105731.Peer-Reviewed Original ResearchConceptsWorking memoryExperiment 1Working-memory taskShifts of attentionStay trialsAttentional orientingAttention domainEveryday cognitionAttention shiftsExperiment 2Shift trialsSpatial attentionAdaptive behaviorBaseline conditionsMemoryEveryday tasksSensory stimulationSensory signalsParticipantsTaskItemsPerceptionCognitionAttentionInternal domain
2023
Heading Direction Tracks Internally Directed Selective Attention in Visual Working Memory
Thom J, Nobre A, van Ede F, Draschkow D. Heading Direction Tracks Internally Directed Selective Attention in Visual Working Memory. Journal Of Cognitive Neuroscience 2023, 35: 856-868. PMID: 36802368, DOI: 10.1162/jocn_a_01976.Peer-Reviewed Original ResearchConceptsVisual working memoryWorking memorySelective attentionOrienting of attentionWorking memory delaysVirtual reality experienceCentral coloured cueGaze biasMemory delayVisual itemsNeural circuitryMemorized locationReality experienceColor cuesOrienting responseVisual representationMemorySensory informationSpatial layoutHead movementsCuesHead orientation responsesExternal environmentItemsMultiple and Dissociable Effects of Sensory History on Working-Memory Performance
Hajonides J, van Ede F, Stokes M, Nobre A, Myers N. Multiple and Dissociable Effects of Sensory History on Working-Memory Performance. Journal Of Neuroscience 2023, 43: 2730-2740. PMID: 36868858, PMCID: PMC10089243, DOI: 10.1523/jneurosci.1200-22.2023.Peer-Reviewed Original ResearchConceptsWorking-memory taskNeural activity patternsRepulsive biasSensory processingBehavioral reportsEarly sensory processing stagesWorking-memory performanceEarly sensory processingSensory processing stageLevels of sensory processingActivity patternsSensory informationPostperceptual processesStimulus encodingAttractiveness biasPostperceptual stagesNeural representationNeural activityWithin-trialEncoding orientationDissociative effectsBehavioral responsesParticipants' reportsHuman brainStimulus history
2022
Functional but not obligatory link between microsaccades and neural modulation by covert spatial attention
Liu B, Nobre A, van Ede F. Functional but not obligatory link between microsaccades and neural modulation by covert spatial attention. Nature Communications 2022, 13: 3503. PMID: 35715471, PMCID: PMC9205986, DOI: 10.1038/s41467-022-31217-3.Peer-Reviewed Original ResearchConceptsCompared to trialsSpatial attentionCovert spatial attentionModulation of alpha activityVisual working memoryModulation of neural activitySpatial modulationNeural modulationEEG alpha activityAlpha activityWorking memoryNeural signaturesNeural activityDirectional biasMemorised locationEye movementsFixational eye movementsMicrosaccades
2021
Temporal orienting in Parkinson’s disease
Zokaei N, Gillebert C, Chauvin J, Gresch D, Board A, Rolinski M, Hu M, Nobre A. Temporal orienting in Parkinson’s disease. European Journal Of Neuroscience 2021, 53: 2713-2725. PMID: 33450082, PMCID: PMC8290223, DOI: 10.1111/ejn.15114.Peer-Reviewed Original ResearchConceptsSpeeded-response taskPerceptual discriminationTemporal orientationIndependent group of individualsParkinson's diseasePerceptual-discrimination taskTemporal orienting of attentionMultiple stages of processingTemporal orienting effectsStream of lettersOrienting of attentionDetect target stimuliImproved perceptual discriminationStages of processingDistracter lettersTarget letterTarget stimuliTask demandsExperiment 1Experiment 2Motor preparationTask contextDopaminergic medicationTemporal expectationsAdaptive behavior
2020
Purpose-Dependent Consequences of Temporal Expectations Serving Perception and Action
van Ede F, Rohenkohl G, Gould I, Nobre A. Purpose-Dependent Consequences of Temporal Expectations Serving Perception and Action. Journal Of Neuroscience 2020, 40: 7877-7886. PMID: 32900836, PMCID: PMC7548698, DOI: 10.1523/jneurosci.1134-20.2020.Peer-Reviewed Original ResearchConceptsTemporal expectationsBrain activityBrain statesFrequency-specific mannerUpcoming perceptionSources of temporal expectationsOscillatory brain activityVisual-motor taskAffected response timesNeurophysiological brain activityBehavioral relevancePerceptual accuracyNeural activityNeural lateralizationNeural statesFemale human volunteersRelevant dimensionsBrainModality-StateTaskHuman volunteersPerceptionResponse speedResponse timeComparing the prioritization of items and feature-dimensions in visual working memory
Hajonides J, van Ede F, Stokes M, Nobre A. Comparing the prioritization of items and feature-dimensions in visual working memory. Journal Of Vision 2020, 20: 25-25. PMID: 32841318, PMCID: PMC7453048, DOI: 10.1167/jov.20.8.25.Peer-Reviewed Original ResearchConceptsVisual working memoryRetro-cueRetrospective cuesWorking memoryNeutral retro-cuesInternal sensory representationsMemory recall performancePosterior alpha oscillationsItem cuesPrioritization of itemsCueing benefitsAttentional prioritizationNeural basisRecall performanceAttentional benefitsBehavioral resultsRecall accuracyTask performanceFeature-dimensionSensory representationsItem levelAlpha oscillationsItem-basedInformation—atCuesOne Thing Leads to Another: Anticipating Visual Object Identity Based on Associative-Memory Templates
Boettcher S, Stokes M, Nobre A, van Ede F. One Thing Leads to Another: Anticipating Visual Object Identity Based on Associative-Memory Templates. Journal Of Neuroscience 2020, 40: 4010-4020. PMID: 32284338, PMCID: PMC7219293, DOI: 10.1523/jneurosci.2751-19.2020.Peer-Reviewed Original ResearchConceptsContingent negative variationTemporal anticipationElectrophysiological signaturesMemory templatesProbabilistic associationsNegative variationAnticipatory mechanismsAlpha oscillationsAlpha-band oscillationsField of attentionAttentional templatesMemory cuesNeural substratesPreparatory attentionTask-relevantExperiment 2Neural mechanismsBehavioral consequencesBehavioral benefitsObject identityMotor responsePerceptual identityElectrophysiological substrateHuman electrophysiologyAnticipatory states
2018
Decoding the influence of anticipatory states on visual perception in the presence of temporal distractors
van Ede F, Chekroud S, Stokes M, Nobre A. Decoding the influence of anticipatory states on visual perception in the presence of temporal distractors. Nature Communications 2018, 9: 1449. PMID: 29654312, PMCID: PMC5899132, DOI: 10.1038/s41467-018-03960-z.Peer-Reviewed Original ResearchConceptsAnticipatory statesTarget representationDistractor resistanceAnticipatory cuesDistractor stimuliBrain responsesPerceptual targetCognitive influencesDistractorsTarget processingVisual perceptionProtective windowStimuliMultivariate stimuliTarget decoderElectroencephalography recordingsIdentity informationStateBenefits of Flexible Prioritization in Working Memory Can Arise Without Costs
Myers N, Chekroud S, Stokes M, Nobre A. Benefits of Flexible Prioritization in Working Memory Can Arise Without Costs. Journal Of Experimental Psychology Human Perception & Performance 2018, 44: 398-411. PMID: 28816476, PMCID: PMC5868459, DOI: 10.1037/xhp0000449.Peer-Reviewed Original Research
2017
Task relevance modulates the behavioural and neural effects of sensory predictions
Auksztulewicz R, Friston K, Nobre A. Task relevance modulates the behavioural and neural effects of sensory predictions. PLOS Biology 2017, 15: e2003143. PMID: 29206225, PMCID: PMC5730187, DOI: 10.1371/journal.pbio.2003143.Peer-Reviewed Original ResearchConceptsTask-relevantMeasure participants' brain activityParticipants' brain activityInfluence of predictabilityGamma-band activityAlpha-band activityIdeal observer modelNeural effectsPredictive signalsTask demandsBrain activityNeural responsesTask performanceSpatial/temporal informationSensory predictionsVisual regionsBrain functionBehavioral responsesSpectral correlationAuditory regionsAuditory cuesInternal predictionsSubjects' predictionsVisual targetDiscrimination accuracyIncreased rostral anterior cingulate activity following positive mental imagery training in healthy older adults
Murphy S, O’Donoghue M, Blackwell S, Nobre A, Browning M, Holmes E. Increased rostral anterior cingulate activity following positive mental imagery training in healthy older adults. Social Cognitive And Affective Neuroscience 2017, 12: 1950-1958. PMID: 29069519, PMCID: PMC5716192, DOI: 10.1093/scan/nsx120.Peer-Reviewed Original ResearchConceptsRostral anterior cingulate cortexRostral anterior cingulate cortex activationHealthy older adultsPositive imageryCognitive trainingRostral anterior cingulate activityFunctional magnetic resonance imaging scansControl trainingMental imagesAmbiguous sentences taskAnterior cingulate activityBilateral hippocampal activationAmbiguous social eventsAnterior cingulate cortexImagery trainingOlder adultsResponse to cuesConsistent with other evidenceProspective imageryCingulate activityMental imagery trainingCingulate cortexAffective episodesHippocampal activitySentence taskMethylphenidate enhances implicit learning in healthy adults
Klinge C, Shuttleworth C, Muglia P, Nobre A, Harmer C, Murphy S. Methylphenidate enhances implicit learning in healthy adults. Journal Of Psychopharmacology 2017, 32: 70-80. PMID: 28946787, DOI: 10.1177/0269881117731472.Peer-Reviewed Original ResearchConceptsMeasures of cognitionImplicit cognition measuresEffects of methylphenidateCognitive measuresImplicit learningImplicit measures of cognitionDose of methylphenidateTask-switching taskCognition-enhancing effectsSensitivity to pharmacological interventionExperimental medicine studiesPharmacological interventionsPriming taskImplicit cognitionDevelopment of pharmacological interventionsImplicit measuresCognitive effectsExplicit measuresEnhance cognitionMethylphenidateHealthy volunteersCognitionAbsence of biomarkersImprove learningMale volunteersPreparatory α-band oscillations reflect spatial gating independently of predictions regarding target identity
Wildegger T, van Ede F, Woolrich M, Gillebert C, Nobre A. Preparatory α-band oscillations reflect spatial gating independently of predictions regarding target identity. Journal Of Neurophysiology 2017, 117: 1385-1394. PMID: 28077669, PMCID: PMC5350265, DOI: 10.1152/jn.00856.2016.Peer-Reviewed Original ResearchConceptsSpatial gatingGating of informationAttentional cuesHuman brain oscillationsTarget identityFeature-based predictionsCue-target intervalVisual targetVisual detection taskFeature-based attentionUpcoming visual targetSpatial attention cuesCovert spatial attentionOscillationsUninformative cuesBehavioral benefitsBrain activityBehavioral levelAnticipatory attentionCortical regionsSpatial attentionA-bandAttended locationSpatial cuesBrain oscillations
2016
Retrospective Attention Interacts with Stimulus Strength to Shape Working Memory Performance
Wildegger T, Humphreys G, Nobre A. Retrospective Attention Interacts with Stimulus Strength to Shape Working Memory Performance. PLOS ONE 2016, 11: e0164174. PMID: 27706240, PMCID: PMC5051714, DOI: 10.1371/journal.pone.0164174.Peer-Reviewed Original ResearchConceptsWorking memoryWM performanceExperiment 2Working memory performanceRetrospective attentionWM taskWM maintenanceWM representationsStimulus contrastOrienting attentionHigh-contrast stimuliMemory performanceExperiment 3Perceptual representationsExperiment 1RetrocueLow-contrast stimuliSpatial attentionInfluence performanceStimuliSub-threshold stimuliMixture-model approachRetrospective orientationStimulus strengthEncodingTemporal Orienting of Attention Can Be Preserved in Normal Aging
Chauvin J, Gillebert C, Rohenkohl G, Humphreys G, Nobre A. Temporal Orienting of Attention Can Be Preserved in Normal Aging. Psychology And Aging 2016, 31: 442-455. PMID: 27294712, PMCID: PMC4976797, DOI: 10.1037/pag0000105.Peer-Reviewed Original ResearchConceptsBehavioral performanceTemporal expectationsRapid serial visual presentation taskTemporal orientationTemporal orienting of attentionOrienting of attentionPredictive temporal cuesYoung adultsLong temporal intervalsReaction timeNeutral cuesTarget stimuliLong foreperiodsTarget itemsVisual discriminationPerceptual functionsOlder individualsNormal agingShort foreperiodsYounger participantsAuditory cuesTemporal cuesCuesValidity benefitsTemporal intervalsBehavioral and Neural Markers of Flexible Attention over Working Memory in Aging
Mok R, Myers N, Wallis G, Nobre A. Behavioral and Neural Markers of Flexible Attention over Working Memory in Aging. Cerebral Cortex 2016, 26: 1831-1842. PMID: 26865653, PMCID: PMC4785959, DOI: 10.1093/cercor/bhw011.Peer-Reviewed Original ResearchConceptsRetro-cueWorking memoryOlder adultsMeasured magnetoencephalographyHigher order cognitionPerformance of older adultsOrienting of attentionWM performanceCueing benefitsWM maintenanceWM representationsMitigate cognitive declineFlexible attentionMemory precisionAttentional benefitsNeural markersOscillatory powerCognitive declineNeural dynamicsMEG recordingsMemoryHealthy agingPreservation of controllabilityRelevant itemsModel-based analysis
2015
Temporal Dynamics of Attention during Encoding versus Maintenance of Working Memory: Complementary Views from Event-related Potentials and Alpha-band Oscillations
Myers N, Walther L, Wallis G, Stokes M, Nobre A. Temporal Dynamics of Attention during Encoding versus Maintenance of Working Memory: Complementary Views from Event-related Potentials and Alpha-band Oscillations. Journal Of Cognitive Neuroscience 2015, 27: 492-508. PMID: 25244118, PMCID: PMC4678590, DOI: 10.1162/jocn_a_00727.Peer-Reviewed Original ResearchConceptsVisual WM taskWorking memoryWM taskMaintenance of working memoryTemporal dynamics of attentionFrontoparietal control networkPatterns of ERPsEvent-related potentialsShifts of attentionDynamics of attentionAlpha-band lateralizationAlpha-band oscillationsAttention-guiding cuesERP profileERP patternsTarget anticipationRobust lateralizationUpcoming informationCue conditionCue typesRecall performanceProcessing differencesRetrocueAnticipatory attentionStimulus anticipation