2024
Neural dynamics of shifting attention between perception and working-memory contents
Gresch D, Boettcher S, Gohil C, van Ede F, Nobre A. Neural dynamics of shifting attention between perception and working-memory contents. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2406061121. PMID: 39536078, PMCID: PMC11588118, DOI: 10.1073/pnas.2406061121.Peer-Reviewed Original ResearchConceptsAttention shiftsBrain activityNeural dynamicsPatterns of human brain activityWorking-memory taskWorking-memory contentsVisual contentInternal memory representationsWorking memoryMemory representationsSequential cuesHuman brain activityMultivariate decodingAlpha lateralizationSpatial attentionNeural statesCuesSensory environmentEveryday tasksTaskPerceptionCombined perceptionAttentionAlternative domainsMagnetoencephalographyA Neural Decision Signal during Internal Sampling from Working Memory in Humans
van Ede F, Nobre A. A Neural Decision Signal during Internal Sampling from Working Memory in Humans. Journal Of Neuroscience 2024, 44: e1475232024. PMID: 38538144, PMCID: PMC11079964, DOI: 10.1523/jneurosci.1475-23.2024.Peer-Reviewed Original ResearchConceptsWorking memoryDomains of working memoryMemory-guided behaviorEvolving decision processesInternal visual representationsNeural evidenceParietal positivitySensory evidenceMental contentMemory contentPurposeful behaviorDecision signalsTime participantsMemorySensory informationInternational sampleMultiple contentsDecision processVisual representationPsychologyDecision-making frameworkNeuroscienceEvidenceBehaviorParticipants
2021
Rhythmic Modulation of Visual Perception by Continuous Rhythmic Auditory Stimulation
Bauer A, van Ede F, Quinn A, Nobre A. Rhythmic Modulation of Visual Perception by Continuous Rhythmic Auditory Stimulation. Journal Of Neuroscience 2021, 41: 7065-7075. PMID: 34261698, PMCID: PMC8372019, DOI: 10.1523/jneurosci.2980-20.2021.Peer-Reviewed Original ResearchConceptsAlignment of neural activityRhythmic structureModulation of neural activityCross-modal entrainmentVisual neural activityRhythmic modulationAuditory stimulationVisual areasFrequency-modulatedRhythmic auditory stimulationNeural activityCross-modal influencesSystematic fluctuationsVisual cortical activityVisual perceptionModulation of visual perceptionVisual stimuliMulti-sensoryCross-modal effectsPerceptual discriminationFluctuationsSensory modalitiesEnergyPacing signalHuman electroencephalographyDecoding visual colour from scalp electroencephalography measurements
Hajonides J, Nobre A, van Ede F, Stokes M. Decoding visual colour from scalp electroencephalography measurements. NeuroImage 2021, 237: 118030. PMID: 33836272, PMCID: PMC8285579, DOI: 10.1016/j.neuroimage.2021.118030.Peer-Reviewed Original Research
2020
Functional biases in attentional templates from associative memory
Boettcher S, van Ede F, Nobre A. Functional biases in attentional templates from associative memory. Journal Of Vision 2020, 20: 7-7. PMID: 33296459, PMCID: PMC7729124, DOI: 10.1167/jov.20.13.7.Peer-Reviewed Original ResearchConceptsParticipants learned associationsCurrent task demandsLong-term memoryAttentional templatesTask demandsTask performanceBehavioral responsesExperimental blocksAssociative memoryMemoryLuresFunctional biasParticipantsContext-dependentEncode informationNonmatchEveryday lifeAssociationFeature dimensionsCombination of colorColored gratingsTaskRetrievalPerceptionHypothesisSuperior short-term memory in APOE ε2 carriers across the age range
Zokaei N, Board A, Slavkova E, Mackay C, Nobre A, Husain M. Superior short-term memory in APOE ε2 carriers across the age range. Behavioural Brain Research 2020, 397: 112918. PMID: 32961217, PMCID: PMC7732594, DOI: 10.1016/j.bbr.2020.112918.Peer-Reviewed Original ResearchConceptsShort-term memoryMemory advantageAssociated with individual differencesShort-term memory taskSignificant memory advantageAlzheimer's diseaseMemory performanceIndividual differencesTask difficultyAD-related pathologyAge rangeCognitive healthE3/E3 carriersSensitive to subtle changesAt-risk cohortElderly adultsApolipoprotein E4 alleleMemoryCognitionCohort of individualsMiddle-agedDevelopment of ADE4 alleleIndividualsPhenotypic effectsGoal-directed and stimulus-driven selection of internal representations
van Ede F, Board A, Nobre A. Goal-directed and stimulus-driven selection of internal representations. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 24590-24598. PMID: 32929036, PMCID: PMC7533705, DOI: 10.1073/pnas.2013432117.Peer-Reviewed Original ResearchConceptsGoal-directedWorking memoryInternal representationInfluence memory performanceVisual working memoryMemory-guided behaviorGuidance of attentionInternal memory representationsStimulus-driven factorsStimulus-driven selectionRelevant sensory informationMemory representationsMemory performanceSelection of relevant sensory informationGaze biasStimulus-drivenAdaptive behaviorMemorySensory informationStimuliPurpose-Dependent Consequences of Temporal Expectations Serving Perception and Action
van Ede F, Rohenkohl G, Gould I, Nobre A. Purpose-Dependent Consequences of Temporal Expectations Serving Perception and Action. Journal Of Neuroscience 2020, 40: 7877-7886. PMID: 32900836, PMCID: PMC7548698, DOI: 10.1523/jneurosci.1134-20.2020.Peer-Reviewed Original ResearchConceptsTemporal expectationsBrain activityBrain statesFrequency-specific mannerUpcoming perceptionSources of temporal expectationsOscillatory brain activityVisual-motor taskAffected response timesNeurophysiological brain activityBehavioral relevancePerceptual accuracyNeural activityNeural lateralizationNeural statesFemale human volunteersRelevant dimensionsBrainModality-StateTaskHuman volunteersPerceptionResponse speedResponse timeComparing the prioritization of items and feature-dimensions in visual working memory
Hajonides J, van Ede F, Stokes M, Nobre A. Comparing the prioritization of items and feature-dimensions in visual working memory. Journal Of Vision 2020, 20: 25-25. PMID: 32841318, PMCID: PMC7453048, DOI: 10.1167/jov.20.8.25.Peer-Reviewed Original ResearchConceptsVisual working memoryRetro-cueRetrospective cuesWorking memoryNeutral retro-cuesInternal sensory representationsMemory recall performancePosterior alpha oscillationsItem cuesPrioritization of itemsCueing benefitsAttentional prioritizationNeural basisRecall performanceAttentional benefitsBehavioral resultsRecall accuracyTask performanceFeature-dimensionSensory representationsItem levelAlpha oscillationsItem-basedInformation—atCuesShort-term memory advantage for brief durations in human APOE ε4 carriers
Zokaei N, Grogan J, Fallon S, Slavkova E, Hadida J, Manohar S, Nobre A, Husain M. Short-term memory advantage for brief durations in human APOE ε4 carriers. Scientific Reports 2020, 10: 9503. PMID: 32528115, PMCID: PMC7289888, DOI: 10.1038/s41598-020-66114-6.Peer-Reviewed Original ResearchConceptsApolipoprotein E4 geneE4 geneAntagonistic pleiotropy effectsAlzheimer's diseaseE4 alleleGenetic risk factorsGene poolDeleterious genesAntagonistic pleiotropyShort-term memoryGenetic variantsApolipoprotein E4 alleleEvolutionary biologyGene allelesGenesMemory advantagePleiotropic effectsAllelesPleiotropy effectsNon-carriersShort-term memory performanceAPOE e4 carriersSignificant memory advantageHuman populationHuman cognitive functionsOne Thing Leads to Another: Anticipating Visual Object Identity Based on Associative-Memory Templates
Boettcher S, Stokes M, Nobre A, van Ede F. One Thing Leads to Another: Anticipating Visual Object Identity Based on Associative-Memory Templates. Journal Of Neuroscience 2020, 40: 4010-4020. PMID: 32284338, PMCID: PMC7219293, DOI: 10.1523/jneurosci.2751-19.2020.Peer-Reviewed Original ResearchConceptsContingent negative variationTemporal anticipationElectrophysiological signaturesMemory templatesProbabilistic associationsNegative variationAnticipatory mechanismsAlpha oscillationsAlpha-band oscillationsField of attentionAttentional templatesMemory cuesNeural substratesPreparatory attentionTask-relevantExperiment 2Neural mechanismsBehavioral consequencesBehavioral benefitsObject identityMotor responsePerceptual identityElectrophysiological substrateHuman electrophysiologyAnticipatory states
2019
Emotional Distraction in the Context of Memory-Based Orienting of Attention
Raeder S, Bone J, Patai E, Holmes E, Nobre A, Murphy S. Emotional Distraction in the Context of Memory-Based Orienting of Attention. Emotion 2019, 19: 1366-1376. PMID: 30676039, PMCID: PMC6886481, DOI: 10.1037/emo0000506.Peer-Reviewed Original ResearchConceptsNeutral facesTask-irrelevant emotional facesGoal-directed behaviorOrienting of attentionLong-term memoryTarget detection taskTrait anxiety scoresAnxious individualsEmotional distractionEmotional distractorsEmotional facesThreatening stimuliMemory cuesTrait anxietyAttentional captureSalient stimuliTask performanceAnxiety scoresDrivers of attentionEndogenous cuesDetection taskDirectional behaviorDistractorsMemoryProlonged disruptionRhythmic Temporal Expectation Boosts Neural Activity by Increasing Neural Gain
Auksztulewicz R, Myers N, Schnupp J, Nobre A. Rhythmic Temporal Expectation Boosts Neural Activity by Increasing Neural Gain. Journal Of Neuroscience 2019, 39: 9806-9817. PMID: 31662425, PMCID: PMC6891052, DOI: 10.1523/jneurosci.0925-19.2019.Peer-Reviewed Original ResearchConceptsTop-down biasRhythmic expectancyIrrelevant distractorsStimulus processingIncreased neural gainNeural sensitivityNeural gainAlignment of neural activityNeural activityTask-relevant targetsImpairing stimulus processingAuditory discrimination taskAuditory stimulus featuresRhythmic temporal expectationBehavioral discrimination accuracyIncreased neural sensitivityNeural decodingDiscrimination taskBrain activityStimulus aspectsTime pointsStimulus streamStimulus featuresTemporal expectationsTask performanceChanging Interpretations of Emotional Expressions in Working Memory With Aging
Mok R, van der Meulen J, Holmes E, Nobre A. Changing Interpretations of Emotional Expressions in Working Memory With Aging. Emotion 2019, 19: 1060-1069. PMID: 30321038, PMCID: PMC6764502, DOI: 10.1037/emo0000481.Peer-Reviewed Original ResearchConceptsWorking memoryYoung adultsInterpretation of emotional expressionsEmotion-laden stimuliAge-related impairmentFearful facesEmotional materialWM performanceWM accuracyEmotional biasExperimental tasksEmotional expressionPositive biasAffective representationsFacial expressionsOlder adultsFuture behaviorMemoryAdultsTaskBiasImpairmentStimuliPositive effectAgeDissociable Catecholaminergic Modulation of Visual Attention: Differential Effects of Catechol-O-Methyltransferase and Dopamine Beta-Hydroxylase Genes on Visual Attention
Shalev N, Vangkilde S, Neville M, Tunbridge E, Nobre A, Chechlacz M. Dissociable Catecholaminergic Modulation of Visual Attention: Differential Effects of Catechol-O-Methyltransferase and Dopamine Beta-Hydroxylase Genes on Visual Attention. Neuroscience 2019, 412: 175-189. PMID: 31195057, PMCID: PMC6645579, DOI: 10.1016/j.neuroscience.2019.05.068.Peer-Reviewed Original ResearchConceptsContinuous performance taskSustained attentionVisual attentionAttentional functionsAttentional selectionPerformance tasksEffects of catechol-O-methyltransferaseGo/No-Go taskDopamine beta-hydroxylase geneBehaviorally relevant visual informationThreshold of visual perceptionCatechol-O-methyltransferaseResponse inhibitionGo/No-GoIgnoring distractionsGenotype statusCatecholaminergic activityGroup differencesTask performanceRelevant visual informationGenes COMTBeta-hydroxylase geneCOMTDifferential effectsDopamineHuman gaze tracks attentional focusing in memorized visual space
van Ede F, Chekroud S, Nobre A. Human gaze tracks attentional focusing in memorized visual space. Nature Human Behaviour 2019, 3: 462-470. PMID: 31089296, PMCID: PMC6546593, DOI: 10.1038/s41562-019-0549-y.Peer-Reviewed Original ResearchThe Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS): study protocol for a randomised controlled, experimental medicine study
Atkinson L, Colbourne L, Smith A, Harmer C, Nobre A, Rendell J, Jones H, Hinds C, Mould A, Tunbridge E, Cipriani A, Geddes J, Saunders K, Harrison P. The Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS): study protocol for a randomised controlled, experimental medicine study. Trials 2019, 20: 120. PMID: 30755265, PMCID: PMC6373140, DOI: 10.1186/s13063-019-3175-0.Peer-Reviewed Original ResearchConceptsMood instabilityExperimental medicine studiesPsychiatric disordersPlacebo-controlled experimental medicine studyL-type calcium channelsAetiology of psychiatric disordersCalcium channel antagonismBipolar disorderHealthy young adultsMoodCognitionCalcium channel geneVoltage-gated calcium channel geneYoung adultsDouble-blindMedicine studiesDisordersAntagonist nicardipineCalcium channelsSleepCACNA1CChannel genesTreat hypertensionOxford studyTherapeutic potentialPunishment-related memory-guided attention: Neural dynamics of perceptual modulation
Suárez-Suárez S, Holguín S, Cadaveira F, Nobre A, Doallo S. Punishment-related memory-guided attention: Neural dynamics of perceptual modulation. Cortex 2019, 115: 231-245. PMID: 30852377, PMCID: PMC6525146, DOI: 10.1016/j.cortex.2019.01.029.Peer-Reviewed Original ResearchConceptsContextual memoryAttentional biasPunishment avoidanceMemory-based attentional biasesMemory-driven attentional biasPositive reward valueAvoidance of punishmentEvent-related potentialsOptimal perceptual decisionsResponses to targetsEarly visual processingVisual search processAssociated with successful avoidanceAvoidance associationsReward valueNeural signaturesAttention taskMotivational valueSuccessful avoidanceTarget stimuliPerceptual decisionsVisual processingPerceptual modulesNeural dynamicsElectrophysiological measurementsThe Functional Consequences of Social Attention for Memory-guided Attention Orienting and Anticipatory Neural Dynamics
Doherty B, van Ede F, Fraser A, Patai E, Nobre A, Scerif G. The Functional Consequences of Social Attention for Memory-guided Attention Orienting and Anticipatory Neural Dynamics. Journal Of Cognitive Neuroscience 2019, 31: 686-698. PMID: 30726182, DOI: 10.1162/jocn_a_01379.Peer-Reviewed Original ResearchConceptsAttentional orientingAlpha-band oscillationsSocial distractorsMemory precisionMemory performanceSocial attentionPoorer memory performanceAttentional biasHealthy human adultsContextual memoryValidity effectDistractor typeEffect of social processesSocial scenesDistractorsNeural dynamicsAnticipatory dynamicsHuman adultsYoung adultsMemoryBidirectional chainFunctional consequencesTarget locationSocial processesAdultsConcurrent visual and motor selection during visual working memory guided action
van Ede F, Chekroud S, Stokes M, Nobre A. Concurrent visual and motor selection during visual working memory guided action. Nature Neuroscience 2019, 22: 477-483. PMID: 30718904, PMCID: PMC6420070, DOI: 10.1038/s41593-018-0335-6.Peer-Reviewed Original Research