2024
Neural dynamics of shifting attention between perception and working-memory contents
Gresch D, Boettcher S, Gohil C, van Ede F, Nobre A. Neural dynamics of shifting attention between perception and working-memory contents. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2406061121. PMID: 39536078, PMCID: PMC11588118, DOI: 10.1073/pnas.2406061121.Peer-Reviewed Original ResearchConceptsAttention shiftsBrain activityNeural dynamicsPatterns of human brain activityWorking-memory taskWorking-memory contentsVisual contentInternal memory representationsWorking memoryMemory representationsSequential cuesHuman brain activityMultivariate decodingAlpha lateralizationSpatial attentionNeural statesCuesSensory environmentEveryday tasksTaskPerceptionCombined perceptionAttentionAlternative domainsMagnetoencephalography
2023
Evidence Accumulation Rate Moderates the Relationship between Enriched Environment Exposure and Age-Related Response Speed Declines
Brosnan M, Pearce D, O’Neill M, Loughnane G, Fleming B, Zhou S, Chong T, Nobre A, Connell R, Bellgrove M. Evidence Accumulation Rate Moderates the Relationship between Enriched Environment Exposure and Age-Related Response Speed Declines. Journal Of Neuroscience 2023, 43: 6401-6414. PMID: 37507230, PMCID: PMC10500991, DOI: 10.1523/jneurosci.2260-21.2023.Peer-Reviewed Original ResearchConceptsCognitive functionBrain healthOlder adultsNeural metricsTrajectories of cognitive agingMarkers of brain healthLevel of cognitive functioningEnriched environmentEvidence accumulation ratesPreservation of cognitive functionGlobal cognitive functionInfluence of EENeurocognitive vulnerabilityCognitive agingCognitive reserveMotor processesSensory evidenceBrain activityNeurocognitive healthEvidence accumulationResponse speedBrain agingAging brainSocial stimulationSpeed declineMicrosaccades transiently lateralise EEG alpha activity
Liu B, Nobre A, van Ede F. Microsaccades transiently lateralise EEG alpha activity. Progress In Neurobiology 2023, 224: 102433. PMID: 36907349, PMCID: PMC10074474, DOI: 10.1016/j.pneurobio.2023.102433.Peer-Reviewed Original ResearchConceptsSpatial cognitionMicrosaccade directionAlpha powerPosterior alpha powerElectrophysiological brain activityEEG alpha powerAlpha activityWorking memoryBrain activityVisual attentionAttempted fixationEye movementsHuman spatial cognitionCognitionSpontaneous fluctuationsMicrosaccadesInvoluntary eye movementsCanonical signatureAlpha
2020
Purpose-Dependent Consequences of Temporal Expectations Serving Perception and Action
van Ede F, Rohenkohl G, Gould I, Nobre A. Purpose-Dependent Consequences of Temporal Expectations Serving Perception and Action. Journal Of Neuroscience 2020, 40: 7877-7886. PMID: 32900836, PMCID: PMC7548698, DOI: 10.1523/jneurosci.1134-20.2020.Peer-Reviewed Original ResearchConceptsTemporal expectationsBrain activityBrain statesFrequency-specific mannerUpcoming perceptionSources of temporal expectationsOscillatory brain activityVisual-motor taskAffected response timesNeurophysiological brain activityBehavioral relevancePerceptual accuracyNeural activityNeural lateralizationNeural statesFemale human volunteersRelevant dimensionsBrainModality-StateTaskHuman volunteersPerceptionResponse speedResponse time
2019
Rhythmic Temporal Expectation Boosts Neural Activity by Increasing Neural Gain
Auksztulewicz R, Myers N, Schnupp J, Nobre A. Rhythmic Temporal Expectation Boosts Neural Activity by Increasing Neural Gain. Journal Of Neuroscience 2019, 39: 9806-9817. PMID: 31662425, PMCID: PMC6891052, DOI: 10.1523/jneurosci.0925-19.2019.Peer-Reviewed Original ResearchConceptsTop-down biasRhythmic expectancyIrrelevant distractorsStimulus processingIncreased neural gainNeural sensitivityNeural gainAlignment of neural activityNeural activityTask-relevant targetsImpairing stimulus processingAuditory discrimination taskAuditory stimulus featuresRhythmic temporal expectationBehavioral discrimination accuracyIncreased neural sensitivityNeural decodingDiscrimination taskBrain activityStimulus aspectsTime pointsStimulus streamStimulus featuresTemporal expectationsTask performanceThe tempos of performance
Shalev N, Bauer A, Nobre A. The tempos of performance. Current Opinion In Psychology 2019, 29: 254-260. PMID: 31302478, PMCID: PMC6996131, DOI: 10.1016/j.copsyc.2019.06.003.Peer-Reviewed Original Research
2018
Encoding-related brain activity and accelerated forgetting in transient epileptic amnesia
Atherton K, Filippini N, Zeman A, Nobre A, Butler C. Encoding-related brain activity and accelerated forgetting in transient epileptic amnesia. Cortex 2018, 110: 127-140. PMID: 29861041, PMCID: PMC6335262, DOI: 10.1016/j.cortex.2018.04.015.Peer-Reviewed Original ResearchConceptsTransient epileptic amnesiaAccelerated forgettingMemory tracesBrain activityEpileptic amnesiaSyndrome of transient epileptic amnesiaEncoding-related activityAnterograde memory tasksFunctional MRI scansEncoding of memoriesVulnerable to interferenceMemory taskBrain systemsRecognition memoryHippocampal activityMemory paradigmRetention intervalMemory impairmentNeural mechanismsPoor memoryAbnormal encodingReduced deactivationWord listsHealthy control subjectsNormal performance
2017
Task relevance modulates the behavioural and neural effects of sensory predictions
Auksztulewicz R, Friston K, Nobre A. Task relevance modulates the behavioural and neural effects of sensory predictions. PLOS Biology 2017, 15: e2003143. PMID: 29206225, PMCID: PMC5730187, DOI: 10.1371/journal.pbio.2003143.Peer-Reviewed Original ResearchConceptsTask-relevantMeasure participants' brain activityParticipants' brain activityInfluence of predictabilityGamma-band activityAlpha-band activityIdeal observer modelNeural effectsPredictive signalsTask demandsBrain activityNeural responsesTask performanceSpatial/temporal informationSensory predictionsVisual regionsBrain functionBehavioral responsesSpectral correlationAuditory regionsAuditory cuesInternal predictionsSubjects' predictionsVisual targetDiscrimination accuracyTemporal alignment of anticipatory motor cortical beta lateralisation in hidden visual‐motor sequences
Heideman S, van Ede F, Nobre A. Temporal alignment of anticipatory motor cortical beta lateralisation in hidden visual‐motor sequences. European Journal Of Neuroscience 2017, 48: 2684-2695. PMID: 28921756, PMCID: PMC6220967, DOI: 10.1111/ejn.13700.Peer-Reviewed Original ResearchConceptsSerial reaction timeModified serial reaction timeUpcoming target locationVisual-motor sequencesAnticipatory preparationBehavioral benefitsBrain activityNeural dynamicsBeta oscillationsModulation of motor cortical excitabilityLateralisationSpatial-temporal sequenceMotor cortical excitabilityReaction timeComparing targetsCortical excitabilityTarget locationThe Cumulative Effects of Predictability on Synaptic Gain in the Auditory Processing Stream
Auksztulewicz R, Barascud N, Cooray G, Nobre A, Chait M, Friston K. The Cumulative Effects of Predictability on Synaptic Gain in the Auditory Processing Stream. Journal Of Neuroscience 2017, 37: 6751-6760. PMID: 28607165, PMCID: PMC5508257, DOI: 10.1523/jneurosci.0291-17.2017.Peer-Reviewed Original ResearchConceptsMagnetic field amplitudeField amplitudeAuditory processing streamSynaptic gainHealthy human volunteersSustained effectCross-spectral densityDynamic causal modelingSlow modulationSynaptic efficacyNeural gain modulationSlow fluctuationsBrain activityModel-based parametersHuman volunteersAuditory cortexModulation of synaptic gainGain modulationGamma activityProcess streamsModulation of brain activityPredictability of stimuliInduced activationEffects of predictabilitySource-level analysisPreparatory α-band oscillations reflect spatial gating independently of predictions regarding target identity
Wildegger T, van Ede F, Woolrich M, Gillebert C, Nobre A. Preparatory α-band oscillations reflect spatial gating independently of predictions regarding target identity. Journal Of Neurophysiology 2017, 117: 1385-1394. PMID: 28077669, PMCID: PMC5350265, DOI: 10.1152/jn.00856.2016.Peer-Reviewed Original ResearchConceptsSpatial gatingGating of informationAttentional cuesHuman brain oscillationsTarget identityFeature-based predictionsCue-target intervalVisual targetVisual detection taskFeature-based attentionUpcoming visual targetSpatial attention cuesCovert spatial attentionOscillationsUninformative cuesBehavioral benefitsBrain activityBehavioral levelAnticipatory attentionCortical regionsSpatial attentionA-bandAttended locationSpatial cuesBrain oscillations
2016
Slow wave sleep and accelerated forgetting
Atherton K, Nobre A, Lazar A, Wulff K, Whittaker R, Dhawan V, Lazar Z, Zeman A, Butler C. Slow wave sleep and accelerated forgetting. Cortex 2016, 84: 80-89. PMID: 27710778, PMCID: PMC5084685, DOI: 10.1016/j.cortex.2016.08.013.Peer-Reviewed Original ResearchConceptsAccelerated long-term forgettingSlow wave sleepMemory benefitsAmount of slow wave sleepWord pair association taskLong-term forgettingBenefits of sleepDeclarative memoryAccelerated forgettingMemory consolidationAssociation taskMemory retentionBrain activityHealthy control groupHealthy participantsMemoryHealthy individualsElectrographic epileptiform activitySleepForgettingEpileptiform activityIndividualsSleep stagesControl groupHealthy people
2015
Modulation of hippocampal theta and hippocampal‐prefrontal cortex function by a schizophrenia risk gene
Cousijn H, Tunbridge E, Rolinski M, Wallis G, Colclough G, Woolrich M, Nobre A, Harrison P. Modulation of hippocampal theta and hippocampal‐prefrontal cortex function by a schizophrenia risk gene. Human Brain Mapping 2015, 36: 2387-2395. PMID: 25757652, PMCID: PMC4672713, DOI: 10.1002/hbm.22778.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrain MappingGenetic Predisposition to DiseaseGenotypeHippocampusHomozygoteHumansKruppel-Like Transcription FactorsMagnetic Resonance ImagingMagnetoencephalographyNeural PathwaysPolymorphism, Single NucleotidePrefrontal CortexRisk FactorsSchizophreniaTheta RhythmYoung AdultConceptsFunctional magnetic resonance imagingHippocampal thetaPrefrontal cortexFunctional connectivityAssociated with functional connectivityHippocampal networkSuperior frontal gyrusSchizophrenia risk genesTheta-band oscillationsDual regression approachNetwork coactivationsZNF804A rs1344706Frontal gyrusZNF804A polymorphismsZNF804A geneBrain regionsBrain activityZNF804ABrain functionSchizophreniaHippocampalInvestigate coactivationOscillatory activityTheta bandMagnetoencephalography
2014
The Neural Dynamics of Fronto-Parietal Networks in Childhood Revealed using Magnetoencephalography
Astle D, Luckhoo H, Woolrich M, Kuo B, Nobre A, Scerif G. The Neural Dynamics of Fronto-Parietal Networks in Childhood Revealed using Magnetoencephalography. Cerebral Cortex 2014, 25: 3868-3876. PMID: 25410426, PMCID: PMC4585520, DOI: 10.1093/cercor/bhu271.Peer-Reviewed Original ResearchConceptsVisual short-term memoryFronto-parietal networkFronto-parietal activityCognitive controlTests of visual short-term memoryVisual short-term memory performanceVisual short-term memory taskDegree of cognitive controlService of memoryTrial-by-trialIndependent component analysisOscillatory brain activityAnticipatory control mechanismsTrial-to-trial variabilityMemory itemsProtracted developmentShort-term memoryCognitive processesChild variablesBrain activityNeural dynamicsTemporal independent component analysisMagnetoencephalographyMemoryChildrenInter- and intra-individual variability in alpha peak frequency
Haegens S, Cousijn H, Wallis G, Harrison P, Nobre A. Inter- and intra-individual variability in alpha peak frequency. NeuroImage 2014, 92: 46-55. PMID: 24508648, PMCID: PMC4013551, DOI: 10.1016/j.neuroimage.2014.01.049.Peer-Reviewed Original ResearchConceptsAlpha peak frequencyAlpha rhythmVisual stimulation conditionsN-back working memory paradigmHealthy human subjectsBeta peak frequencyWorking memory paradigmN-back paradigmN-back taskBetween-subject SDIncreased cognitive demandsAlpha frequency bandPassive visual stimulationPeak frequencyElectrophysiological evidenceIntra-individual variabilityMemory paradigmParietal cortexCognitive processesBrain activityPosterior regionCognitive demandsAlpha activityStimulation conditionsOccipital sources
2013
Reward Associations Magnify Memory-based Biases on Perception
Doallo S, Patai E, Nobre A. Reward Associations Magnify Memory-based Biases on Perception. Journal Of Cognitive Neuroscience 2013, 25: 245-257. PMID: 23066690, DOI: 10.1162/jocn_a_00314.Peer-Reviewed Original ResearchConceptsReward outcomesNeural processesEarly perceptual stageMemory-guided attentionEffect of spatial memoryLocations of relevant objectsContextual memoryPerceptual stageSpatial memoryBehavioral measuresBrain activityRecordings of brain activityRewardOptimal perceptionMemoryImpact perceptionsRelevant objectsTarget objectPerceptionBiasComplex scenesDiscriminationOutcomesSource of predictabilityComplex environments
2011
Biasing Perception by Spatial Long-Term Memory
Summerfield J, Rao A, Garside N, Nobre A. Biasing Perception by Spatial Long-Term Memory. Journal Of Neuroscience 2011, 31: 14952-14960. PMID: 22016528, PMCID: PMC6623569, DOI: 10.1523/jneurosci.5541-10.2011.Peer-Reviewed Original ResearchConceptsLong-term memoryNeural activityParticipants detected visual targetsSpatial long-term memoryEarly stages of visual analysisEarly perceptual analysisStages of visual analysisNaturalistic visual scenesImprove behavioral performanceOscillatory brain activityBehavioral performanceSpatial memoryBrain activityPerceptual functionsTask goalsBiased perceptionsNovel locationsPerceptual analysisRecord neural activityHuman brainVisual targetMemoryVisual sceneTarget locationTarget detection performanceAlpha Oscillations Related to Anticipatory Attention Follow Temporal Expectations
Rohenkohl G, Nobre A. Alpha Oscillations Related to Anticipatory Attention Follow Temporal Expectations. Journal Of Neuroscience 2011, 31: 14076-14084. PMID: 21976492, PMCID: PMC4235253, DOI: 10.1523/jneurosci.3387-11.2011.Peer-Reviewed Original ResearchConceptsTemporal expectationsAlpha-band activityTarget stimuliOscillatory alpha-band activityAlpha desynchronizationCortical excitabilityRegulate cortical excitabilityEvent-related potentialsRegulate excitabilityTask-relevant eventsOscillatory brain activityExcitationPerceptual discriminationOcclusion periodBrain activitySpatial attentionSpatial expectationsAlpha oscillationsEnhancement of processesTime courseBandOccluding bandAlpha bandVisual areasOscillationsResponse inhibition results in the emotional devaluation of faces: neural correlates as revealed by fMRI
Doallo S, Raymond J, Shapiro K, Kiss M, Eimer M, Nobre A. Response inhibition results in the emotional devaluation of faces: neural correlates as revealed by fMRI. Social Cognitive And Affective Neuroscience 2011, 7: 649-659. PMID: 21642353, PMCID: PMC3427860, DOI: 10.1093/scan/nsr031.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingResponse inhibitionNeural mechanismsBrain activityTop-down inhibitory mechanismsSocial Emotional EvaluationResponse to facesSocial-emotional networkGo/No-Go taskTask 2TASK-1Amygdala activationExecutive controlResponse-selectionBehavioral ratingsGo/No-GoInhibitory controlBrain mechanismsRating taskBehavioral measuresBrain areasResponse suppressionAffective responsesValue representationMagnetic resonance imagingMarkers of preparatory attention predict visual short-term memory performance
Murray A, Nobre A, Stokes M. Markers of preparatory attention predict visual short-term memory performance. Neuropsychologia 2011, 49: 1458-1465. PMID: 21335015, PMCID: PMC3318119, DOI: 10.1016/j.neuropsychologia.2011.02.016.Peer-Reviewed Original ResearchConceptsCue-related changesContralateral delay activityPreparatory attentionVisual short-term memoryMemory-based performancePreparatory brain activityEncoded itemsEncoding taskProbe itemERP markersMemory representationsMemory loadMemory recallShort-term memoryAccurate memory recallBrain activityRecall probabilityRecall accuracySpatial attentionAttention positivityPrecision of recallSpatial cuesBehavioral dataEarly attentionDelayed activation