1999
Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13C NMR
Shen J, Petersen K, Behar K, Brown P, Nixon T, Mason G, Petroff O, Shulman G, Shulman R, Rothman D. Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13C NMR. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 8235-8240. PMID: 10393978, PMCID: PMC22218, DOI: 10.1073/pnas.96.14.8235.Peer-Reviewed Original ResearchConceptsGlutamate/glutamine cycleGlutamine cycleCerebral cortexMin/Rat cerebral cortexVivo 13C NMR spectraGlucose oxidation ratesHuman brainGlucose oxidationGlutamatergic activityRat modelTricarboxylic acid cycle rateParietal lobeHuman cortexCortexTime courseBrainGlutamine synthesisMajor metabolic fluxCycle rateTricarboxylic acid cycleHigh levelsInfusionRatsAcid cycle
1993
Glycolysis-Citric Acid Cycle Interrelation: A New Approach and Some Insights in Cellular and Subcellular Compartmentation
Lai J, Behar K. Glycolysis-Citric Acid Cycle Interrelation: A New Approach and Some Insights in Cellular and Subcellular Compartmentation. Developmental Neuroscience 1993, 15: 181-193. PMID: 7805570, DOI: 10.1159/000111334.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsInner mitochondrial membraneMetabolic compartmentationCitric acid cycleTestable hypothesesSubcellular compartmentationSubcellular aspectsMitochondrial membraneSubcellular fractionationPrimary culturesEnzymatic stepsRegulatory roleAcid cycleParticular pathwayGlycolytic fluxNeural cellsSubcellular studiesCompartmentationRecent methodological advancesSubcellular fractionsVivo NMR dataGlial cellsRegulationPathwayMechanistic issuesMethodological advances