Kene Mezue, MD, MSc
Clinical FellowAbout
Research
Publications
2024
Anxiety and depression are associated with heightened risk of incident deep vein thrombosis: Mediation through stress‐related neural mechanisms
Rosovsky R, Mezue K, Gharios C, Civieri G, Cardeiro A, Zureigat H, Lau H, Pitman R, Shin L, Abohashem S, Osborne M, Jaffer F, Tawakol A. Anxiety and depression are associated with heightened risk of incident deep vein thrombosis: Mediation through stress‐related neural mechanisms. American Journal Of Hematology 2024, 99: 1927-1938. PMID: 38965839, PMCID: PMC11502251, DOI: 10.1002/ajh.27427.Peer-Reviewed Original ResearchTreatment of anxietyAssociated with heightened riskDeep vein thrombosisNeural mechanismsHeart rate variabilityAutonomic system activityMediation analysisVein thrombosisHs-CRPNeural activityAnxietyDepressionCortical activityIncident deep vein thrombosisF-FDG PET/CT imagingHigh-sensitivity C-reactive proteinFemale participantsMedian follow-upC-reactive proteinDVT risk factorsMedian ageMass General Brigham BiobankRetrospective studyChronic inflammationFollow-upINSTANT DIGITAL CONSULT FOR EVIDENCE-BASED INTERPRETATION OF HIGH-SENSITIVITY SERUM TROPONIN IN MYOCARDIAL INJURY
Ye Z, Maayah M, Wang P, See C, Grubman S, Akhlaghi N, Allen S, Dong W, Ghare M, Gokhan I, Grubman D, Mezue K, Mottola G, Park D, Trejo-Paredes C, Shen M, Vemmou E, Abdullah A, Alaiwi S, Sharma S, Gupta N, Gandhi P, Wang Y, Kwan J, Hu J. INSTANT DIGITAL CONSULT FOR EVIDENCE-BASED INTERPRETATION OF HIGH-SENSITIVITY SERUM TROPONIN IN MYOCARDIAL INJURY. Journal Of The American College Of Cardiology 2024, 83: 2522. DOI: 10.1016/s0735-1097(24)04512-1.Peer-Reviewed Original ResearchEffect of Stress-Related Neural Pathways on the Cardiovascular Benefit of Physical Activity
Zureigat H, Osborne M, Abohashem S, Mezue K, Gharios C, Grewal S, Cardeiro A, Naddaf N, Civieri G, Abbasi T, Radfar A, Aldosoky W, Seligowski A, Wasfy M, Guseh J, Churchill T, Rosovsky R, Fayad Z, Rosenzweig A, Baggish A, Pitman R, Choi K, Smoller J, Shin L, Tawakol A. Effect of Stress-Related Neural Pathways on the Cardiovascular Benefit of Physical Activity. Journal Of The American College Of Cardiology 2024, 83: 1543-1553. PMID: 38631773, PMCID: PMC11164527, DOI: 10.1016/j.jacc.2024.02.029.Peer-Reviewed Original ResearchConceptsCardiovascular disease eventsPhysical activityCardiovascular diseaseCVD riskBenefits of physical activityMass General Brigham BiobankElectronic health recordsIncident CVD eventsReduce CVD riskDecrease CVDCardiovascular disease riskPA surveyGreater PANeural activityPA benefitsHealth recordsPotential cardiovascular diseaseCVD eventsPreexisting depressionGuideline recommendationsStress-related activationCardiovascular disease benefitMultivariate modelDepressionNeural effectsClinical Biochemistry of Serum Troponin
Gokhan I, Dong W, Grubman D, Mezue K, Yang D, Wang Y, Gandhi P, Kwan J, Hu J. Clinical Biochemistry of Serum Troponin. Diagnostics 2024, 14: 378. PMID: 38396417, PMCID: PMC10887818, DOI: 10.3390/diagnostics14040378.Peer-Reviewed Original ResearchAcute coronary syndromeFalse negative test resultsPoint of care assayInterpretation of serum levelsNegative test resultsTroponin complexChest painInterpretation of assay resultsSerum levelsClinical workupCoronary syndromeTn assaysMyocardial injuryTest characteristicsClinical settingCare assaysTroponinMeasurement assaysMolecular characteristicsPotential causesAssay resultsAssayMolecular structureFalse resultsConstituent proteins
2023
Reply Causal Pathway of Alcohol Intake: Stress-Related Neuronal Activity and Cardiovascular Risk
Mezue K, Abohashem S, Osborne M, Tawakol A. Reply Causal Pathway of Alcohol Intake: Stress-Related Neuronal Activity and Cardiovascular Risk. Journal Of The American College Of Cardiology 2023, 82: e227-e228. PMID: 38030356, PMCID: PMC10752352, DOI: 10.1016/j.jacc.2023.09.825.Peer-Reviewed Original ResearchEXCESSIVE DAYTIME SLEEPINESS IS ASSOCIATED WITH INCIDENT HEART FAILURE IN A CLINICAL POPULATION WITH OBSTRUCTIVE SLEEP APNEA
SAEED G, OGUNMOLA I, OTITE F, LAMIKANRA O, OSONDU C, MEZUE K, FEHER A, YAGGI H, ANENI E. EXCESSIVE DAYTIME SLEEPINESS IS ASSOCIATED WITH INCIDENT HEART FAILURE IN A CLINICAL POPULATION WITH OBSTRUCTIVE SLEEP APNEA. CHEST Journal 2023, 164: a6312. DOI: 10.1016/j.chest.2023.07.4065.Peer-Reviewed Original ResearchUneven burden of cardiac amyloidosis in people of African descent — global imbalance in resources and access
Madu E, Mezue K. Uneven burden of cardiac amyloidosis in people of African descent — global imbalance in resources and access. BMC Global And Public Health 2023, 1: 15. DOI: 10.1186/s44263-023-00016-3.Peer-Reviewed Original ResearchTTR-CABlack populationHealthcare financing mechanismsPublic health budgetsCardiac amyloidosisGlobal health equityAt-risk populationsHeart failureHealth literacyHealth equityHealth workersTransthyretin cardiac amyloidosisHealth budgetDiastolic heart failureImprove accessPoor awarenessWest African ancestryDisease RegistryCenters of excellenceInternational Center of ExcellenceUneven burdenFinancial remunerationCaribbean populationGenetic basisAfrican ancestryReduced Stress-Related Neural Network Activity Mediates the Effect of Alcohol on Cardiovascular Risk
Mezue K, Osborne M, Abohashem S, Zureigat H, Gharios C, Grewal S, Radfar A, Cardeiro A, Abbasi T, Choi K, Fayad Z, Smoller J, Rosovsky R, Shin L, Pitman R, Tawakol A. Reduced Stress-Related Neural Network Activity Mediates the Effect of Alcohol on Cardiovascular Risk. Journal Of The American College Of Cardiology 2023, 81: 2315-2325. PMID: 37316112, PMCID: PMC10333800, DOI: 10.1016/j.jacc.2023.04.015.Peer-Reviewed Original ResearchConceptsNeural network activityAlcohol consumptionMACE riskEffects of alcoholAssociated with lower MACE riskHealth behavior surveyMass General Brigham BiobankNetwork activityBrain networksLower MACE riskChronic stressMedian follow-upLight/moderate alcohol consumptionCardiovascular risk factorsAdverse cardiovascular eventsAssociated with larger decreasesBrain imagingPotential health detrimentCardiovascular eventsFollow-upBehavior SurveyCardiovascular riskRisk factorsCardiovascular diseaseMACEGenetic Variation in Intercellular Adhesion Molecule-1 (ICAM-1) and Diastolic Heart Failure in the Black Population in the United States
Mezue K, Driggin E. Genetic Variation in Intercellular Adhesion Molecule-1 (ICAM-1) and Diastolic Heart Failure in the Black Population in the United States. Journal Of Cardiac Failure 2023, 29: 1173-1174. PMID: 37062471, DOI: 10.1016/j.cardfail.2023.03.021.Peer-Reviewed Original ResearchFocused cardiac ultrasound in pregnancy
Edwards P, Anyaogu C, Mezue K, Baugh D, Goha A, Egbuche O, Nunura F, Madu E. Focused cardiac ultrasound in pregnancy. Journal Of Investigative Medicine 2023, 71: 81-91. PMID: 36691704, DOI: 10.1177/10815589221142195.Peer-Reviewed Original ResearchConceptsFocused cardiac ultrasoundRheumatic heart diseaseCardiac diseaseMaternal morbidityMaternal outcomesMaternal mortality review committeesHeart diseaseAssociated with poor maternal outcomeCause of maternal mortalityCardiac ultrasoundMortality Review CommitteePoor maternal outcomeSymptoms of normal pregnancyMiddle-income countriesExcessive maternal morbidityHigh-income countriesPoint of careAcquired cardiac diseaseManagement of cardiac diseaseMaternal mortalityEmergency medicineDiagnosis of cardiac diseaseNormal pregnancyTreatment of heart diseasePrompt recognition