Synergistic, multi-level understanding of psychedelics: three systematic reviews and meta-analyses of their pharmacology, neuroimaging and phenomenology
Shinozuka K, Jerotic K, Mediano P, Zhao A, Preller K, Carhart-Harris R, Kringelbach M. Synergistic, multi-level understanding of psychedelics: three systematic reviews and meta-analyses of their pharmacology, neuroimaging and phenomenology. Translational Psychiatry 2024, 14: 485. PMID: 39632810, PMCID: PMC11618481, DOI: 10.1038/s41398-024-03187-1.Peer-Reviewed Original ResearchConceptsFunctional connectivityBetween-network functional connectivityLevels of analysisWithin-network FCBetween-drug differencesMeta-analysesD2 receptorsPsychedelic effectsSerotonergic psychedelicsNeuroimaging resultsNeuropsychiatric disordersStates of consciousnessPsychedelicsNeural fingerprintsAltered statesNeuroimagingPsilocybinHigh dosesLSDSignificantly higher ratesMolecular pharmacologySystematic reviewAddictionDepressionPhenomenologyReconsidering evidence for psychedelic-induced psychosis: an overview of reviews, a systematic review, and meta-analysis of human studies
Sabé M, Sulstarova A, Glangetas A, De Pieri M, Mallet L, Curtis L, Richard-Lepouriel H, Penzenstadler L, Seragnoli F, Thorens G, Zullino D, Preller K, Böge K, Leucht S, Correll C, Solmi M, Kaiser S, Kirschner M. Reconsidering evidence for psychedelic-induced psychosis: an overview of reviews, a systematic review, and meta-analysis of human studies. Molecular Psychiatry 2024, 1-33. PMID: 39592825, DOI: 10.1038/s41380-024-02800-5.Peer-Reviewed Original ResearchRandomized-controlled trialsTreatment-resistant depressionEfficacy of psychedelicsPsychedelic-assisted therapyMeta-analysis of human studiesMeta-analytic dataOverview of reviewsMeta-analysisPre-registered protocolSystematic reviewNegative symptomsWorsen psychosisPsychotic symptomsPsychotic disordersSchizophreniaPsychosisCase-control studySymptom exacerbationPsychosis incidenceRandom-effects modelReview evidenceStandardized assessmentAssessment of study qualityCohort studyClinical trials