Synergistic, multi-level understanding of psychedelics: three systematic reviews and meta-analyses of their pharmacology, neuroimaging and phenomenology
Shinozuka K, Jerotic K, Mediano P, Zhao A, Preller K, Carhart-Harris R, Kringelbach M. Synergistic, multi-level understanding of psychedelics: three systematic reviews and meta-analyses of their pharmacology, neuroimaging and phenomenology. Translational Psychiatry 2024, 14: 485. PMID: 39632810, PMCID: PMC11618481, DOI: 10.1038/s41398-024-03187-1.Peer-Reviewed Original ResearchConceptsFunctional connectivityBetween-network functional connectivityLevels of analysisWithin-network FCBetween-drug differencesMeta-analysesD2 receptorsPsychedelic effectsSerotonergic psychedelicsNeuroimaging resultsNeuropsychiatric disordersStates of consciousnessPsychedelicsNeural fingerprintsAltered statesNeuroimagingPsilocybinHigh dosesLSDSignificantly higher ratesMolecular pharmacologySystematic reviewAddictionDepressionPhenomenologyThe influence of psilocybin on subconscious and conscious emotional learning
Casanova A, Ort A, Smallridge J, Preller K, Seifritz E, Vollenweider F. The influence of psilocybin on subconscious and conscious emotional learning. IScience 2024, 27: 110034. PMID: 38883812, PMCID: PMC11177198, DOI: 10.1016/j.isci.2024.110034.Peer-Reviewed Original ResearchPsychedelic-assisted psychotherapyAgonist psilocybinFearful facesNeutral cuesEmotional cuesPsychiatric disordersSerotonergic psychedelicsSerotonin signalingExploratory behaviorPsilocybinEmotional learningLearning effectCuesPlacebo groupPlaceboPsychotherapyLearning rateLearningPsychedelicsSerotoninReinforcement learningDisordersTreatment modalitiesBrainTask