2023
New insights into the glycobiology of immune thrombocytopenia.
Tiemeyer KH, Kuter DJ, Cairo CW, Hollenhorst MA. New insights into the glycobiology of immune thrombocytopenia. Curr Opin Hematol 2023 PMID: 37526945, DOI: 10.1097/MOH.0000000000000781.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsGlycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE.
Chongsaritsinsuk J, Steigmeyer AD, Mahoney KE, Rosenfeld MA, Lucas TM, Ince D, Kearns FL, Battison AS, Hollenhorst MA, Shon DJ, Tiemeyer KH, Attah V, Kwon C, Bertozzi CR, Ferracane MJ, Amaro RE, Malaker SA. Glycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE. BioRxiv 2023 PMID: 36778266, DOI: 10.1101/2023.02.01.526488.Peer-Reviewed Original Research In PressComprehensive analysis of platelet glycoprotein Ibα ectodomain glycosylation
Hollenhorst M, Tiemeyer K, Mahoney K, Aoki K, Ishihara M, Lowery S, Rangel-Angarita V, Bertozzi C, Malaker S. Comprehensive analysis of platelet glycoprotein Ibα ectodomain glycosylation. Journal Of Thrombosis And Haemostasis 2023, 21: 995-1009. PMID: 36740532, PMCID: PMC10065957, DOI: 10.1016/j.jtha.2023.01.009.Peer-Reviewed Original ResearchConceptsO-glycositesGPIb-IX-V complexMajor ligand-binding subunitAmino acid sitesLigand-binding subunitVon Willebrand factor bindingPlatelet glycoprotein IbαMechanosensory domainFactor bindingEndogenous proteinsRecombinant proteinsN-glycositesStructural rolePlatelet biologyGlycan structuresGlycoprotein IbαO-glycansT antigenGlycosylation profileDiverse repertoireGlycosylationGlycansComprehensive analysisGlycositesVon Willebrand factorDefective phagocytosis leads to neurodegeneration through systemic increased innate immune signaling.
Elguero JE, Liu G, Tiemeyer K, Gandevia H, Duro L, McCall K. Defective phagocytosis leads to neurodegeneration through systemic increased innate immune signaling. BioRxiv 2023 PMID: 36711924, DOI: 10.1101/2023.01.08.523170.Peer-Reviewed Original Research In Press
2017
COG7 deficiency in Drosophila generates multifaceted developmental, behavioral and protein glycosylation phenotypes.
Frappaolo A, Sechi S, Kumagai T, Robinson S, Fraschini R, Karimpour-Ghahnavieh A, Belloni G, Piergentili R, Tiemeyer KH, Tiemeyer M, Giansanti MG. COG7 deficiency in Drosophila generates multifaceted developmental, behavioral and protein glycosylation phenotypes. J Cell Sci 2017, 130: 3637-3649. PMID: 28883096, DOI: 10.1242/jcs.209049.Peer-Reviewed Original Research