2006
Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways
Liu L, Li F, Cardelli J, Martin K, Blenis J, Huang S. Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways. Oncogene 2006, 25: 7029-7040. PMID: 16715128, DOI: 10.1038/sj.onc.1209691.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCattleCell Cycle ProteinsCell LineCell MovementCytoprotectionDown-RegulationEnzyme ActivationHumansInsulin-Like Growth Factor IMicePhosphoproteinsPhosphorylationProtein KinasesRibosomal Protein S6 Kinases, 70-kDaSerumSignal TransductionSirolimusTOR Serine-Threonine KinasesTranscription FactorsConceptsCell motilityRNA interferenceEukaryotic initiation factor 4EDownregulation of RaptorType I insulin-like growth factorMTOR kinase activityInitiation factor 4ES6 kinase 1Rapamycin inhibitionTumor cell motilityResistant mutantsSuppression of mTORP70 S6K1Kinase activityKinase 1S6K1Mammalian targetRapamycinProtein 1Effect of rapamycinConsequence of inhibitionCell linesMutantsRaptorsMotility
1997
A Competitive Mechanism of CArG Element Regulation by YY1 and SRF: Implications for Assessment of Phox1/MHox Transcription Factor Interactions at CArG Elements
Martin K, Gualberto A, Kolman M, Lowry J, Walsh K. A Competitive Mechanism of CArG Element Regulation by YY1 and SRF: Implications for Assessment of Phox1/MHox Transcription Factor Interactions at CArG Elements. DNA And Cell Biology 1997, 16: 653-661. PMID: 9174170, DOI: 10.1089/dna.1997.16.653.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsCells, CulturedChick EmbryoDNA-Binding ProteinsErythroid-Specific DNA-Binding FactorsGene Expression RegulationHomeodomain ProteinsMuscle, SkeletalNuclear ProteinsPoint MutationPromoter Regions, GeneticSequence Analysis, DNASerum Response FactorTranscription FactorsYY1 Transcription FactorConceptsSerum response factorMuscle-specific expressionCArG elementsTranscription factor serum response factorTranscription factor interactionsDNA regulatory elementsMuscle-specific genesSkeletal alpha-actinImmediate early genesCArG boxSRF bindingTranscriptional activationRegulatory elementsPoint mutantsYY1 repressionSerum inductionYY1Regulatory factorsEarly genesYY1 overexpressionAlpha-actinRepressionPoint mutationsResponse factorMutants