2024
Anesthetic Risk with Large Mediastinal Masses: A Management Framework Based on a Systematic Review
Saffarzadeh A, Popescu W, Detterbeck F, Li A, Blasberg J. Anesthetic Risk with Large Mediastinal Masses: A Management Framework Based on a Systematic Review. The Annals Of Thoracic Surgery 2024 PMID: 39307215, DOI: 10.1016/j.athoracsur.2024.09.011.Peer-Reviewed Original ResearchMediastinal massSystematic reviewManagement of patientsVery-high-riskDegree of airwayDegree of symptomsAnatomic compressionRespiratory decompensationRetrospective seriesVascular compressionCase reportAnesthetic managementCategories of low-Anesthetic riskWriting panelIndividual patientsLow riskPubMed databaseDecompensationPatientsHigher-riskPotential decompensationAnesthesiaBack-up planReactive interventionsThe Scenic Route: Lingular Metastasectomy Through the Right Chest
Udelsman B, Blasberg J. The Scenic Route: Lingular Metastasectomy Through the Right Chest. Annals Of Thoracic Surgery Short Reports 2024, 2: 506-508. DOI: 10.1016/j.atssr.2024.03.010.Peer-Reviewed Original ResearchRight chestMinimally invasive wedge resectionIsolated pulmonary metastasesIpsilateral chestIsolated metastasisOverall-survivalPulmonary metastasesSurgical resectionWedge resectionAnterior mediastinumThoracoscopic approachDisease-freeLeft thoracotomyResectionMetastasectomyChestMetastasisPatientsPleurodesisMediastinumThoracotomyAssessment of online information on robotic cardiac and thoracic surgery
Hameed I, Amabile A, Candelario K, Khan S, Li E, Fereydooni S, Almeida M, Latif N, Ahmed A, Dhanasopon A, Krane M, Blasberg J, Geirsson A. Assessment of online information on robotic cardiac and thoracic surgery. Journal Of Robotic Surgery 2024, 18: 41. PMID: 38231324, DOI: 10.1007/s11701-023-01794-6.Peer-Reviewed Original ResearchConceptsThoracic surgeryAmount of contentConfidence intervalsOnline informationReadability of online resourcesOnline health informationSystematic online searchPerioperative informationCardiothoracic surgeonsOnline health resourcesAcademic websitesSurgeryPatientsReadability of websitesThoracicMultivariate regressionHigher accuracyWebsite accuracyPatient useHealth informationReadabilityWebsitesAccuracyAssociated with higher accuracyIndependent panel
2022
A guide for managing patients with stage I NSCLC: deciding between lobectomy, segmentectomy, wedge, SBRT and ablation— part 1: a guide to decision-making
Detterbeck FC, Blasberg JD, Woodard GA, Decker RH, Kumbasar U, Park HS, Mase VJ, Bade BC, Li AX, Brandt WS, Madoff DC. A guide for managing patients with stage I NSCLC: deciding between lobectomy, segmentectomy, wedge, SBRT and ablation— part 1: a guide to decision-making. Journal Of Thoracic Disease 2022, 0: 0-0. PMID: 35813719, PMCID: PMC9264102, DOI: 10.21037/jtd-21-1823.Peer-Reviewed Original ResearchLong-term outcomesIndividual patientsHealthy patientsLung cancerFavorable tumorsStage I lung cancerBetter long-term outcomesI lung cancerStage I NSCLCOlder patientsPatient selectionPoint of careSurgical approachClinical careEffect modifiersTreatment selectionPatientsTreatment approachesPatient valuesClinical judgmentSystematic reviewRelevant outcomesLong-term differencesAvailable evidenceShort-term differencesA guide for managing patients with stage I NSCLC: deciding between lobectomy, segmentectomy, wedge, SBRT and ablation—part 2: systematic review of evidence regarding resection extent in generally healthy patients
Detterbeck FC, Mase VJ, Li AX, Kumbasar U, Bade BC, Park HS, Decker RH, Madoff DC, Woodard GA, Brandt WS, Blasberg JD. A guide for managing patients with stage I NSCLC: deciding between lobectomy, segmentectomy, wedge, SBRT and ablation—part 2: systematic review of evidence regarding resection extent in generally healthy patients. Journal Of Thoracic Disease 2022, 0: 0-0. PMID: 35813747, PMCID: PMC9264068, DOI: 10.21037/jtd-21-1824.Peer-Reviewed Original ResearchNon-randomized comparisonHealthy patientsResection extentIndividual patientsSystematic reviewStage I lung cancerI lung cancerStage I NSCLCCharacteristics of patientsPulmonary function testsLong-term outcomesRisk of recurrenceVideo-assisted approachSublobar resectionWedge resectionRandomized trialsFunction testsLung cancerResidual confoundingEffect modifiersShort-term benefitsLobectomyPatientsPubMed systematic reviewMargin distanceA guide for managing patients with stage I NSCLC: deciding between lobectomy, segmentectomy, wedge, SBRT and ablation—part 4: systematic review of evidence involving SBRT and ablation
Park HS, Detterbeck FC, Madoff DC, Bade BC, Kumbasar U, Mase VJ, Li AX, Blasberg JD, Woodard GA, Brandt WS, Decker RH. A guide for managing patients with stage I NSCLC: deciding between lobectomy, segmentectomy, wedge, SBRT and ablation—part 4: systematic review of evidence involving SBRT and ablation. Journal Of Thoracic Disease 2022, 0: 0-0. PMID: 35813762, PMCID: PMC9264060, DOI: 10.21037/jtd-21-1826.Peer-Reviewed Original ResearchLong-term outcomesNon-randomized comparisonIndividual patientsSystematic reviewStage I lung cancerI lung cancerCharacteristics of patientsStage I NSCLCPulmonary function testsMinority of patientsShort-term outcomesStereotactic body radiotherapyThermal ablationLate toxicityPulmonary functionRandomized trialsFunction testsAdjusted comparisonsBody radiotherapyLung cancerResidual confoundingEffect modifiersShort-term benefitsPatientsPubMed systematic reviewRevisiting Indications for Brain Imaging During the Clinical Staging Evaluation of Lung Cancer
Pichert MD, Canavan ME, Maduka RC, Li AX, Ermer T, Zhan PL, Kaminski M, Udelsman BV, Blasberg JD, Mase VJ, Dhanasopon AP, Boffa DJ. Revisiting Indications for Brain Imaging During the Clinical Staging Evaluation of Lung Cancer. JTO Clinical And Research Reports 2022, 3: 100318. PMID: 35540711, PMCID: PMC9079298, DOI: 10.1016/j.jtocrr.2022.100318.Peer-Reviewed Original ResearchPrevalence of brainBrain metastasesSummary stageBrain imagingN classificationIsolated brain metastasesNode-negative NSCLCRoutine brain imagingStage II NSCLCStage IV NSCLCClinical stage INational Cancer DatabaseEarly-stage NSCLCStage IAStage IIIAStage NSCLCStaging evaluationClinical stageLung cancerCancer DatabaseN stageNSCLCPatientsStage IMetastasis
2021
The Survival Advantage of Lobectomy over Wedge Resection Lessens as Health-Related Life Expectancy Decreases
Salazar MC, Canavan ME, Walters SL, Chilakamarry S, Ermer T, Blasberg JD, Yu JB, Gross CP, Boffa DJ. The Survival Advantage of Lobectomy over Wedge Resection Lessens as Health-Related Life Expectancy Decreases. JTO Clinical And Research Reports 2021, 2: 100143. PMID: 34590002, PMCID: PMC8474228, DOI: 10.1016/j.jtocrr.2021.100143.Peer-Reviewed Original ResearchStage I NSCLCWedge resectionSurveillance EpidemiologyMortality riskHigh riskSurvival advantageLife expectancyNational Cancer Institute's Surveillance EpidemiologyEnd Results-MedicareTreatment-naive patientsEarly-stage NSCLCRetrospective cohort studySuperior local controlShort life expectancyLife expectancy decreasesPerioperative complicationsCohort studyComorbid conditionsLung parenchymaLobectomyCox modelReasonable optionPatientsNSCLCLocal control
2020
Navigating by Stars: Using CMS Star Ratings to Choose Hospitals for Complex Cancer Surgery
Papageorge MV, Resio BJ, Monsalve AF, Canavan M, Pathak R, Mase VJ, Dhanasopon AP, Hoag JR, Blasberg JD, Boffa DJ. Navigating by Stars: Using CMS Star Ratings to Choose Hospitals for Complex Cancer Surgery. JNCI Cancer Spectrum 2020, 4: pkaa059-. PMID: 33134834, PMCID: PMC7583163, DOI: 10.1093/jncics/pkaa059.Peer-Reviewed Original ResearchComplex cancer surgeryCMS star ratingsCancer surgerySafe hospitalReassignment of patientsMedicare Provider AnalysisYears of ageHospital mortalitySurgical outcomesSurgical careMedicare beneficiariesMortality ratePatientsSurgeryHospitalHospital qualityReview filesMedicaid ServicesMortalityOnly modest impactOutcomesStar ratingsModest impactYearsRobotic Thoracic Surgery
Schwartz G, Sancheti M, Blasberg J. Robotic Thoracic Surgery. Surgical Clinics Of North America 2020, 100: 237-248. PMID: 32169178, DOI: 10.1016/j.suc.2019.12.001.Peer-Reviewed Original ResearchConceptsThoracic surgical interventionRobotic thoracic surgeryLung resectionMediastinal tumorMajor anatomic structuresSurgical managementSurgical interventionThoracic incisionMeticulous dissectionThoracic surgeryImproved outcomesPathologic conditionsRobotic approachAnatomic regionsInvasive surgeryBenefits translateAnatomic structuresSurgeryDissectionOutcomesMorbidityResectionPatientsTumorsChest
2019
OA13.07 Neoadjuvant Atezolizumab in Resectable NSCLC Patients: Immunophenotyping Results from the Interim Analysis of the Multicenter Trial LCMC3
Oezkan F, He K, Owen D, Pietrzak M, Cho J, Kitzler R, Pearson R, Rusch V, Chaft J, Suh R, Blasberg J, Reckamp K, Raz D, Kneuertz P, Fiorillo L, Garon E, Nicholas A, Johnson A, Schulze K, Grindheim J, Banchereau R, Phan S, Bunn P, Kwiatkowski D, Johnson B, Kris M, Wistuba I, Lee J, Lozanski G, Carbone D. OA13.07 Neoadjuvant Atezolizumab in Resectable NSCLC Patients: Immunophenotyping Results from the Interim Analysis of the Multicenter Trial LCMC3. Journal Of Thoracic Oncology 2019, 14: s242-s243. DOI: 10.1016/j.jtho.2019.08.482.Peer-Reviewed Original ResearchDigital Inference of Immune Microenvironment Reveals Low-Risk Subtype of Early Lung Adenocarcinoma
Kurbatov V, Balayev A, Saffarzadeh A, Heller DR, Boffa DJ, Blasberg JD, Lu J, Khan SA. Digital Inference of Immune Microenvironment Reveals Low-Risk Subtype of Early Lung Adenocarcinoma. The Annals Of Thoracic Surgery 2019, 109: 343-349. PMID: 31568747, DOI: 10.1016/j.athoracsur.2019.08.050.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma of LungAdultAgedCohort StudiesDatabases, FactualDisease-Free SurvivalFemaleHumansImmunotherapyKaplan-Meier EstimateLung NeoplasmsMaleMiddle AgedNeoplasm InvasivenessNeoplasm StagingPneumonectomyPrognosisProportional Hazards ModelsRetrospective StudiesRisk AssessmentSurvival AnalysisTumor MicroenvironmentConceptsTumor immune microenvironmentImmune microenvironmentLung adenocarcinomaOverall survivalRisk groupsMast cellsCox proportional hazard modelingEarly-stage lung adenocarcinomaLow-risk subtypesKaplan-Meier analysisPathological staging systemProportional hazard modelingImproved clinical outcomesCancer immune microenvironmentImmune cell typesEarly lung adenocarcinomaActivation stateClinical outcomesValidation cohortMacrophage contentStaging systemMultivariable modelCIBERSORT analysisPatientsClinical decisionQuality Versus Quantity
Chiu AS, Arnold BN, Hoag JR, Herrin J, Kim CH, Salazar MC, Monsalve AF, Jean RA, Blasberg JD, Detterbeck FC, Gross CP, Boffa DJ. Quality Versus Quantity. Annals Of Surgery 2019, Publish Ahead of Print: &na;. PMID: 29697446, DOI: 10.1097/sla.0000000000002762.Peer-Reviewed Original ResearchConceptsComplex cancer surgeryCancer surgerySafe hospitalComplex oncologic surgeryPotential mortality reductionNational Cancer DatabaseHigh-volume hospitalsHospital quality measuresSurgical mortalityPrimary cancerHospital rating systemsOncologic surgeryCancer DatabaseMortality reductionSurgical volumeHospital safetyPatient realignmentPatientsHospitalSurgeryMeaningful reductionPublic reportingMortalityRSMRCancerBig data, big contributions: outcomes research in thoracic surgery
Resio BJ, Dhanasopon AP, Blasberg JD. Big data, big contributions: outcomes research in thoracic surgery. Journal Of Thoracic Disease 2019, 11: s566-s573. PMID: 31032075, PMCID: PMC6465425, DOI: 10.21037/jtd.2019.01.04.Peer-Reviewed Original ResearchShort Tandem Repeats Define a Gestational Origin for Metastatic Choriocarcinoma
Brown K, Homer R, Baine M, Blasberg JD. Short Tandem Repeats Define a Gestational Origin for Metastatic Choriocarcinoma. The Annals Of Thoracic Surgery 2019, 108: e115-e117. PMID: 30685255, DOI: 10.1016/j.athoracsur.2018.12.038.Peer-Reviewed Original ResearchConceptsPlacenta accretaSpontaneous hemothoraxGestational choriocarcinomaLower lobe massMetastatic gestational choriocarcinomaHealthy female patientsAdjuvant therapyMetastatic choriocarcinomaSurgical explorationChief complaintFemale patientsOutside hospitalRare consequenceUnreported causeGestational originClinical implicationsChoriocarcinomaAccretaHemothoraxResectionPatientsPrognosisHospitalShortnessTherapy
2018
Variable impact of prior cancer history on the survival of lung cancer patients
Monsalve AF, Hoag JR, Resio BJ, Chiu AS, Brown LB, Detterbeck FC, Blasberg JD, Boffa DJ. Variable impact of prior cancer history on the survival of lung cancer patients. Lung Cancer 2018, 127: 130-137. PMID: 30642541, DOI: 10.1016/j.lungcan.2018.11.040.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerPrior cancer historyNational Cancer DatabaseCancer historyOverall survivalNSCLC patientsMultivariable Cox proportional hazards regression modelsTreatment approachesCox proportional hazards regression modelProportional hazards regression modelsKaplan-Meier survival curvesNSCLC patient survivalCell lung cancerHazards regression modelsLung cancer patientsPrior cancerPrior malignancyNSCLC survivalPatient survivalCancer patientsLung cancerCancer DatabasePatient's potentialPrior historyPatientsIdentifying Drivers of Multiple Readmissions After Pulmonary Lobectomy
Jean RA, Chiu AS, Hoag JR, Blasberg JD, Boffa DJ, Detterbeck FC, Kim AW. Identifying Drivers of Multiple Readmissions After Pulmonary Lobectomy. The Annals Of Thoracic Surgery 2018, 107: 947-953. PMID: 30336117, DOI: 10.1016/j.athoracsur.2018.08.070.Peer-Reviewed Original ResearchConceptsPulmonary lobectomyMultiple readmissionsSecond readmissionFirst readmissionIndex hospitalizationPostoperative infectionLung cancerPrimary diagnosisHeart diseaseClinical Classification Software codesNationwide Readmissions DatabaseTime of readmissionPostoperative arrhythmiasPostoperative complicationsPostoperative sepsisPerioperative periodPostoperative periodClinical factorsReadmissionLobectomyPatientsStudy periodImportant markerDiagnosisHealthcare qualitySurvival Rates after Thermal Ablation versus Stereotactic Radiation Therapy for Stage 1 Non-Small Cell Lung Cancer: A National Cancer Database Study.
Uhlig J, Ludwig JM, Goldberg SB, Chiang A, Blasberg JD, Kim HS. Survival Rates after Thermal Ablation versus Stereotactic Radiation Therapy for Stage 1 Non-Small Cell Lung Cancer: A National Cancer Database Study. Radiology 2018, 289: 862-870. PMID: 30226453, DOI: 10.1148/radiol.2018180979.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerStage 1 non-small cell lung cancerStereotactic radiation therapyCell lung cancerOverall survivalLung cancerThermal ablationRadiation therapySurvival ratePropensity score-matched cohortUnplanned hospital readmission ratesNational Cancer DatabaseUnplanned hospital readmissionOverall survival rateHospital readmission ratesSmaller tumor sizeMore comorbiditiesReadmission ratesHospital readmissionRetrospective studyTumor sizePotential confoundersCancer DatabasePrimary treatmentPatientsEvaluation of ground glass nodules
Mironova V, Blasberg JD. Evaluation of ground glass nodules. Current Opinion In Pulmonary Medicine 2018, 24: 350-354. PMID: 29634577, DOI: 10.1097/mcp.0000000000000492.Peer-Reviewed Original ResearchConceptsGround-glass nodulesLocal treatment optionsCAT scanTreatment optionsLung cancerMediastinal windowEarly-stage lung cancerNonsmall cell lung cancerGlass nodulesChest CAT scansHigh-risk patientsLarge prospective studiesSingle-institution dataSignificant solid componentSolid componentsSurgical resectionFavorable prognosisProspective studyInterval imagingImaging featuresDistinguish patientsNodule progressionLower riskSignificant progressionPatientsRobotic-Assisted Lobectomies in the National Cancer Database
Arnold BN, Thomas DC, Narayan R, Blasberg JD, Detterbeck FC, Boffa DJ, Kim AW. Robotic-Assisted Lobectomies in the National Cancer Database. Journal Of The American College Of Surgeons 2018, 226: 1052-1062.e15. PMID: 29574177, DOI: 10.1016/j.jamcollsurg.2018.03.023.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseRobotic lobectomyLung cancerCancer DatabaseOutcomes of patientsPropensity-matched analysisThoracoscopic surgery lobectomyExperienced hospitalsOverall conversion ratePerioperative morbidityPrimary outcomePatient selectionAttendant sequelaeOpen procedureLobectomyAssisted LobectomyHigh mortalityHospitalPatientsMortalityIndividual hospitalsRate of conversionSignificant differencesYears of experienceOutcomes