2024
Acute Kidney Injury in Patients with Cirrhosis and Chronic Kidney Disease: Results from the HRS-HARMONY Consortium
St. Hillien S, Robinson J, Ouyang T, Patidar K, Belcher J, Cullaro G, Regner K, Chung R, Ufere N, Velez J, Neyra J, Asrani S, Wadei H, Teixeira J, Saly D, Levitsky J, Orman E, Sawinski D, Dageforde L, Allegretti A, Consortium H. Acute Kidney Injury in Patients with Cirrhosis and Chronic Kidney Disease: Results from the HRS-HARMONY Consortium. Clinical Gastroenterology And Hepatology 2024 PMID: 39675402, DOI: 10.1016/j.cgh.2024.10.023.Peer-Reviewed Original ResearchAcute kidney injuryChronic kidney diseaseLiver function parametersKidney diseaseKidney injuryAssociated with lower 90-day mortalityRates of intensive care unit admissionLiver diseaseAlcohol-associated liver diseaseIntensive care unit admissionMELD-Na scoreRenal replacement therapyShort-term outcomesFunction parametersComparison of outcomesPeak creatinineAdmission creatinineTransplant listing statusReplacement therapyUnit admissionPrimary outcomeCirrhosisMetabolic dysfunctionHospitalized patientsPatientsAssociation of HRS-AKI with Mortality in Patients with Cirrhosis Requiring Renal Replacement Therapy: Results from the HRS-HARMONY Consortium.
Cama-Olivares A, Ouyang T, Takeuchi T, St Hillien S, Robinson J, Chung R, Cullaro G, Karvellas C, Levitsky J, Orman E, Patidar K, Regner K, Saly D, Sawinski D, Sharma P, Teixeira J, Ufere N, Velez J, Wadei H, Wahid N, Allegretti A, Neyra J, Belcher J. Association of HRS-AKI with Mortality in Patients with Cirrhosis Requiring Renal Replacement Therapy: Results from the HRS-HARMONY Consortium. Kidney360 2024 PMID: 39348201, DOI: 10.34067/kid.0000000589.Peer-Reviewed Original ResearchEtiology of AKIHRS-AKIAKI-RRTRenal replacement therapyContinuous RRTIntermittent hemodialysisAdult patientsHospitalized patientsAKI etiologyReplacement therapyAssociated with increased 90-day mortalityMulticenter retrospective cohort studyNon-HRS-AKIAssociated with increased mortalityConsecutive adult patientsRetrospective cohort studyHospital network systemHepatorenal syndromeContemporary cohortInpatient populationMechanical ventilationRRT modalityCohort studyClinical variablesPrimary outcomeImpact of acute kidney injury response on survival and liver transplant rates in hospitalized patients with cirrhosis awaiting liver transplantation: Results from the HRS-HARMONY consortium
Li X, Ouyang T, Belcher J, Patidar K, Cullaro G, Asrani S, Wadei H, Simonetto D, Regner K, Dageforde L, Przybyszewski E, Wilechansky R, Sharma P, Ufere N, Duarte-Rojo A, Wahid N, Orman E, St. Hillien S, Robinson J, Chung R, Allegretti A, collaborative I. Impact of acute kidney injury response on survival and liver transplant rates in hospitalized patients with cirrhosis awaiting liver transplantation: Results from the HRS-HARMONY consortium. Liver Transplantation 2024, 30: 1106-1115. PMID: 39073567, DOI: 10.1097/lvt.0000000000000445.Peer-Reviewed Original ResearchAKI responseAcute kidney injuryTransplant-free survivalLiver transplantationLT ratesCirrhosis patientsNon-respondersTime of liver transplantationCourse of hospitalized patientsNo responseRetrospective multicenter studyMELD-Na scoreResponse to therapyResponse to treatmentLiver transplant ratesRate of LTOverall survivalMulticenter studyKidney injuryCirrhosis etiologyCirrhosisHospitalized patientsTransplantationPatientsInjury response
2012
Association of AKI With mortality and complications in hospitalized patients with cirrhosis
Belcher JM, Garcia‐Tsao G, Sanyal AJ, Bhogal H, Lim JK, Ansari N, Coca SG, Parikh CR, Consortium F. Association of AKI With mortality and complications in hospitalized patients with cirrhosis. Hepatology 2012, 57: 753-762. PMID: 22454364, PMCID: PMC3390443, DOI: 10.1002/hep.25735.Peer-Reviewed Original ResearchConceptsAcute kidney injuryAcute Kidney Injury Network definitionAssociation of AKIDefinition of AKISeverity of AKIProgression of AKIProspective observational cohort studyAKIN stage 1Baseline renal functionObservational cohort studyIncidence of mortalityAKI criteriaAKI severityAKI stageAKIN criteriaAKIN stageHospital mortalityKidney injuryCohort studyDevastating complicationRenal functionHospitalized patientsImproved outcomesEarly diagnosisTimely treatment