2024
In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization
Kaushik R, McAvay G, Murphy T, Acampora D, Araujo K, Charpentier P, Chattopadhyay S, Geda M, Gill T, Kaminski T, Lee S, Li J, Cohen A, Hajduk A, Ferrante L. In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization. JAMA Network Open 2024, 7: e2419640. PMID: 38954414, PMCID: PMC11220565, DOI: 10.1001/jamanetworkopen.2024.19640.Peer-Reviewed Original ResearchConceptsIn-hospital deliriumChart-Based Delirium Identification InstrumentOlder adultsFunctional disabilityCOVID-19 hospitalizationCognitive impairmentCohort studyAssociated with increased functional disabilityHospitalized older adultsIncreased functional disabilityAssociation of deliriumPostdischarge follow-upRisk of deliriumTertiary care systemFollow-upPresence of cognitive impairmentProspective cohort studyLogistic regression modelsOlder survivorsCare systemIncreasing cognitive impairmentMain OutcomesCOVID-19Hospital dischargePrimary outcomeAssessment of disparities in timely diagnosis and comprehensive workup of cognitive impairment between English and Spanish speakers
Silva-Rudberg J, Carrión C, Pérez-Palmer N, Li J, Mehta S, Diab N, Mecca A, O'Dell R. Assessment of disparities in timely diagnosis and comprehensive workup of cognitive impairment between English and Spanish speakers. American Journal Of Geriatric Psychiatry 2024, 32: 773-786. PMID: 38336573, PMCID: PMC11162952, DOI: 10.1016/j.jagp.2024.01.030.Peer-Reviewed Original ResearchDiagnosis of mild cognitive impairmentSpanish-speaking patientsMild cognitive impairmentHispanic/Latino patientsCognitive impairmentNon-English language preferenceLanguage preferenceComprehension of diagnosisImpact of language barriersAssessment of disparitiesDiagnosis of cognitive impairmentSpanish language preferenceDiagnosis of dementiaElectronic medical recordsCross-sectional studyTimeliness of diagnosisDementia careRetrospective cross-sectional studyDementia diagnosisHealth disparitiesU.S. Hispanic/Latino populationBinomial logistic regressionNeighborhood disadvantageSpanish speakersHealth care
2021
Lower cerebral oxygen utilization is associated with Alzheimer’s disease-related neurodegeneration and poorer cognitive performance among apolipoprotein E ε4 carriers
Robb W, Khan O, Ahmed H, Li J, Moore E, Cambronero F, Pechman K, Liu D, Gifford K, Landman B, Donahue M, Hohman T, Jefferson A. Lower cerebral oxygen utilization is associated with Alzheimer’s disease-related neurodegeneration and poorer cognitive performance among apolipoprotein E ε4 carriers. Cerebrovascular And Brain Metabolism Reviews 2021, 42: 642-655. PMID: 34743630, PMCID: PMC9051148, DOI: 10.1177/0271678x211056393.Peer-Reviewed Original ResearchConceptsEpisodic memory performanceCognitive performancePathogenesis of Alzheimer's diseaseMemory performanceAlzheimer's disease-related neurodegenerationPoorer cognitive performanceE4 carriersLateral ventricle volumeExecutive functionEpisodic memoryOxygen homeostasisDisease-related neurodegenerationAlzheimer's diseaseBrain agingCognitive impairmentNeuroimaging variablesE4 statusCerebral metabolic rateVentricle volumeOlder adultsBad languageHippocampalNeurodegenerationMetabolic rateMetabolism