2022
Bedside detection of intracranial midline shift using portable magnetic resonance imaging
Sheth KN, Yuen MM, Mazurek MH, Cahn BA, Prabhat AM, Salehi S, Shah JT, By S, Welch EB, Sofka M, Sacolick LI, Kim JA, Payabvash S, Falcone GJ, Gilmore EJ, Hwang DY, Matouk C, Gordon-Kundu B, RN AW, Petersen N, Schindler J, Gobeske KT, Sansing LH, Sze G, Rosen MS, Kimberly WT, Kundu P. Bedside detection of intracranial midline shift using portable magnetic resonance imaging. Scientific Reports 2022, 12: 67. PMID: 34996970, PMCID: PMC8742125, DOI: 10.1038/s41598-021-03892-7.Peer-Reviewed Original ResearchConceptsMidline shiftNeuroscience intensive care unitCare measurementYale-New Haven HospitalValuable bedside toolIntensive care unitPoor clinical outcomeBrain-injured patientsMass effectNew Haven HospitalMagnetic resonance imagingClinical outcomesIll patientsCare unitStroke patientsFunctional outcomeBedside toolObservational studyBedside detectionImaging examsPatientsResonance imagingPortable MRIImaging suiteSignificant concordance
2021
Drip-and-ship versus mothership for endovascular treatment of acute stroke: A comparative effectiveness analysis
Wu X, Wira C, Matouk C, Forman H, Gandhi D, Sanelli P, Schindler J, Malhotra A. Drip-and-ship versus mothership for endovascular treatment of acute stroke: A comparative effectiveness analysis. International Journal Of Stroke 2021, 17: 315-322. PMID: 33759645, DOI: 10.1177/17474930211008701.Peer-Reviewed Original ResearchConceptsComprehensive stroke centerPrimary stroke centerAcute stroke patientsNearest comprehensive stroke centerAcute strokeMothership strategyStroke centersStroke patientsPlace of onsetHealth benefitsMarkov decision-analytic modelComparative effectiveness analysisRecent medical literatureMultiple sensitivity analysesDecision analytic modelMothership modelPrimary outcomeEndovascular treatmentPrehospital triageSudden onsetPatientsMedical literatureStrokeShip strategyTarget population
2020
Classification of Stroke
Amin H, Schindler J. Classification of Stroke. 2020, 67-83. DOI: 10.1007/978-3-030-52552-1_7.Peer-Reviewed Original ResearchStroke Treatment, Early Management, and Secondary Prevention
Amin H, Schindler J. Stroke Treatment, Early Management, and Secondary Prevention. 2020, 85-105. DOI: 10.1007/978-3-030-52552-1_8.Peer-Reviewed Original ResearchSecondary preventionStroke treatmentAcute ischemic patientsMost stroke patientsStent retrieval deviceAcute stroke treatmentModifiable risk factorsOnset of symptomsAmerican Heart AssociationStroke neurologistsAcute strokeSelect patientsMost strokesStroke patientsAcute interventionCerebrovascular diseaseStroke managementTherapeutic optionsHeart AssociationIschemic patientsEarly managementRisk factorsTreatment windowPatientsManagement guidelinesDirect carotid puncture for mechanical thrombectomy in acute ischemic stroke patients with prohibitive vascular access.
Cord BJ, Kodali S, Strander S, Silverman A, Wang A, Chouairi F, Koo AB, Nguyen CK, Peshwe K, Kimmel A, Porto CM, Hebert RM, Falcone GJ, Sheth KN, Sansing LH, Schindler JL, Matouk CC, Petersen NH. Direct carotid puncture for mechanical thrombectomy in acute ischemic stroke patients with prohibitive vascular access. Journal Of Neurosurgery 2020, 135: 53-63. PMID: 32796146, PMCID: PMC9491727, DOI: 10.3171/2020.5.jns192737.Peer-Reviewed Original ResearchDirect carotid punctureSmaller infarct volumesMechanical thrombectomyVascular accessFunctional outcomeAIS-LVONIHSS scoreDCP groupInfarct volumeTransfemoral accessNeck hematomaStroke patientsCarotid punctureABMT groupAnterior circulation acute ischemic strokeCommon carotid artery dissectionAcute ischemic stroke patientsDirect carotid accessEmergency mechanical thrombectomyAcute ischemic strokeAdmission NIHSS scoreCarotid artery dissectionIschemic stroke patientsGood functional outcomeLarge vessel occlusionDeployment of Portable, Bedside, Low-field Magnetic Resonance Imaging for Evaluation of Stroke Patients (272)
Cahn B, Shah J, Dyvorne H, O’Halloran R, Poole M, Yuen M, Mazurek M, Ward A, Payabvash S, Beekman R, Brown S, Falcone G, Gobeske K, Petersen N, Jasne A, Sharma R, Schindler J, Sansing L, Gilmore E, Wira C, Matouk C, Sze G, Rosen M, Kimberly W, Sheth K. Deployment of Portable, Bedside, Low-field Magnetic Resonance Imaging for Evaluation of Stroke Patients (272). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.272.Peer-Reviewed Original ResearchRisk of Worse Outcome in Stroke Patients with High Blood Pressure Variability After Endovascular Thrombectomy May Be Amplified by Impaired Cerebral Autoregulation (4457)
Nguyen C, Silverman A, Wang A, Kodali S, Strander S, Kimmel A, Peshwe K, de Havenon A, Gilmore E, Sansing L, Schindler J, Matouk C, Sheth K, Petersen N. Risk of Worse Outcome in Stroke Patients with High Blood Pressure Variability After Endovascular Thrombectomy May Be Amplified by Impaired Cerebral Autoregulation (4457). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.4457.Peer-Reviewed Original ResearchFixed Compared With Autoregulation-Oriented Blood Pressure Thresholds After Mechanical Thrombectomy for Ischemic Stroke
Petersen NH, Silverman A, Strander SM, Kodali S, Wang A, Sansing LH, Schindler JL, Falcone GJ, Gilmore EJ, Jasne AS, Cord B, Hebert RM, Johnson M, Matouk CC, Sheth KN. Fixed Compared With Autoregulation-Oriented Blood Pressure Thresholds After Mechanical Thrombectomy for Ischemic Stroke. Stroke 2020, 51: 914-921. PMID: 32078493, PMCID: PMC7050651, DOI: 10.1161/strokeaha.119.026596.Peer-Reviewed Original ResearchConceptsSystolic BP thresholdMean arterial pressureArterial pressureEndovascular thrombectomyIschemic strokeSystolic BPFunctional outcomePercent timeFurther brain injuryModified Rankin ScaleBlood pressure changesPoor functional outcomeBP thresholdAutoregulatory indexHemorrhagic transformationMechanical thrombectomyRankin ScaleBlood pressureBP targetsHemodynamic managementAcute phaseBP managementStroke patientsCerebral autoregulationWorse outcomes
2019
Percutaneous Trans-Carotid Puncture for Mechanical Thrombectomy in Acute Ischemic Stroke Patients is Safe and Effective: A Large, Single-Center Case Series
Cord B, Wang A, Chouairi F, Koo A, Porto C, Silverman A, Kodali S, Strander S, Falcone G, Sheth K, Hebert R, Sansing L, Schindler J, Petersen N, Matouk C. Percutaneous Trans-Carotid Puncture for Mechanical Thrombectomy in Acute Ischemic Stroke Patients is Safe and Effective: A Large, Single-Center Case Series. Neurosurgery 2019, 66: 310-167. DOI: 10.1093/neuros/nyz310_167.Peer-Reviewed Original ResearchComparative Effectiveness of Endovascular Thrombectomy in Elderly Stroke Patients
Malhotra A, Wu X, Payabvash S, Matouk CC, Forman HP, Gandhi D, Sanelli P, Schindler J. Comparative Effectiveness of Endovascular Thrombectomy in Elderly Stroke Patients. Stroke 2019, 50: 963-969. PMID: 30908156, DOI: 10.1161/strokeaha.119.025031.Peer-Reviewed Original ResearchConceptsQuality-adjusted life yearsIntravenous thrombolysisEndovascular thrombectomyLarge vessel occlusionAge 80 yearsEVT strategyVessel occlusionModified Rankin Scale scorePoststroke functional outcomeAcute ischemic strokeRankin Scale scoreElderly stroke patientsMarkov decision-analytic modelYears of ageDecision analytic modelMultiple sensitivity analysesPurpose- StrokeAcute strokeBaseline disabilityElderly patientsIschemic strokeStroke patientsFunctional outcomeHealthy patientsAdvanced age
2018
History of Intracranial Hemorrhage Is Associated with In-Hospital Mortality in Ischemic Stroke Patients Treated with Intravenous Thrombolytics
Sommaruga S, Chu S, Hwang D, Dearborn J, Sansing L, Cord B, Santarosa C, Samarth G, Petersen N, Gilmore E, Schindler J, Bijlenga P, Schaller K, Matouk C, Sheth K, Falcone G. History of Intracranial Hemorrhage Is Associated with In-Hospital Mortality in Ischemic Stroke Patients Treated with Intravenous Thrombolytics. Journal Of Neurological Surgery Part A Central European Neurosurgery 2018, 79: s1-s27. DOI: 10.1055/s-0038-1660745.Peer-Reviewed Original Research
2017
Acute Ischemic Stroke
Nyström K, Schindler J. Acute Ischemic Stroke. 2017, 93-115. DOI: 10.1007/978-3-319-48669-7_6.ChaptersAcute ischemic strokeIschemic strokeAdvanced practice cliniciansStroke teamStroke carePractice cliniciansAcute neurological deficitsAcute stroke presentationsPotential stroke patientsSubsequent inpatient careIntravenous thrombolytic therapyAcute stroke careAcute stroke teamEmergency department physiciansCertified stroke centersNeurological deficitsStroke centersNeurological examinationStroke presentationInitial treatmentStroke patientsThrombolytic therapyDepartment physiciansStroke systemsInpatient care
2016
Stroke Treatment and Management
Amin H, Schindler J. Stroke Treatment and Management. 2016, 63-80. DOI: 10.1007/978-3-319-39605-7_8.ChaptersStroke treatmentAcute ischemic patientsMost stroke patientsStent retrieval deviceAcute stroke treatmentModifiable risk factorsOnset of symptomsAmerican Heart AssociationStroke neurologistsAcute strokeSecondary preventionSelect patientsMost strokesStroke patientsAcute interventionCerebrovascular diseaseStroke managementTherapeutic optionsHeart AssociationIschemic patientsRisk factorsPatientsT-PAManagement guidelinesStrokeStroke Rehab
Amin H, Schindler J. Stroke Rehab. 2016, 171-176. DOI: 10.1007/978-3-319-39605-7_18.ChaptersClassification of Stroke
Amin H, Schindler J. Classification of Stroke. 2016, 51-62. DOI: 10.1007/978-3-319-39605-7_7.ChaptersValidation of TURN, a simple predictor of symptomatic intracerebral hemorrhage after IV thrombolysis
Asuzu D, Nystrӧm K, Amin H, Schindler J, Wira C, Greer D, Fang NF, Halliday J, Sheth KN. Validation of TURN, a simple predictor of symptomatic intracerebral hemorrhage after IV thrombolysis. Clinical Neurology And Neurosurgery 2016, 146: 71-75. PMID: 27152469, DOI: 10.1016/j.clineuro.2016.04.017.Peer-Reviewed Original ResearchConceptsSymptomatic intracerebral hemorrhageIntracerebral hemorrhageRt-PAOdds ratioYale-New Haven HospitalNINDS rt-PA trialIschemic stroke patientsNew Haven HospitalTwo-sample t-testStroke patientsCharacteristic curveThrombolysisHemorrhageSignificant differencesPatientsT-testScoresExternal datasetSimple predictorInternal datasetHospital
2015
On- versus Off-Hour Patient Cohorts at a Primary Stroke Center: Onset-to-Treatment Duration and Clinical Outcomes after IV Thrombolysis
Asuzu D, Nystrӧm K, Amin H, Schindler J, Wira C, Greer D, Fang NF, Halliday J, Sheth KN. On- versus Off-Hour Patient Cohorts at a Primary Stroke Center: Onset-to-Treatment Duration and Clinical Outcomes after IV Thrombolysis. Journal Of Stroke And Cerebrovascular Diseases 2015, 25: 447-451. PMID: 26654664, DOI: 10.1016/j.jstrokecerebrovasdis.2015.10.017.Peer-Reviewed Original ResearchConceptsSymptomatic intracerebral hemorrhagePrimary stroke centerClinical outcomesStroke centersStroke severitySymptom onsetStroke careStroke patientsPatient cohortIntravenous recombinant tissue plasminogen activator (rt-PA) therapyTreatment durationRecombinant tissue plasminogen activator therapyHealth Stroke Scale scoreTissue plasminogen activator therapyConsistent quality careBaseline National InstitutesStroke Scale scoreAcute stroke careIschemic stroke patientsPlasminogen activator therapyMann-Whitney testSICH rateAcute strokeIschemic strokeConsecutive patientsTURN Score Predicts 24-Hour Cerebral Edema After IV Thrombolysis
Asuzu D, Nyström K, Sreekrishnan A, Schindler J, Wira C, Greer D, Halliday J, Kimberly WT, Sheth KN. TURN Score Predicts 24-Hour Cerebral Edema After IV Thrombolysis. Neurocritical Care 2015, 24: 381-388. PMID: 26341364, DOI: 10.1007/s12028-015-0198-6.Peer-Reviewed Original ResearchConceptsSymptomatic intracerebral hemorrhageBrain swellingIntracerebral hemorrhageCerebral edemaPoor outcomeSevere outcomesOdds ratioLogistic regression reporting odds ratiosNINDS rt-PA trialIschemic stroke patientsReporting odds ratioNew brainNew onsetMidline shiftStroke patientsRt-PAEdemaThrombolysisMortalityOutcomesMass effectCharacteristic curveHemorrhagePatientsStatistical associationTURN Score Predicts 90-day Outcome in Acute Ischemic Stroke Patients After IV Thrombolysis
Asuzu D, Nyström K, Schindler J, Wira C, Greer D, Halliday J, Sheth KN. TURN Score Predicts 90-day Outcome in Acute Ischemic Stroke Patients After IV Thrombolysis. Neurocritical Care 2015, 23: 172-178. PMID: 26032809, DOI: 10.1007/s12028-015-0154-5.Peer-Reviewed Original ResearchConceptsSymptomatic intracerebral hemorrhageGOS scoreSevere outcomesConfidence intervalsOdds ratioLogistic regression reporting odds ratiosScale scoreAcute ischemic stroke patientsGlasgow Outcome Scale scoreSPAN-100NINDS rt-PA trialIschemic stroke patientsBarthel Index scoreRankin Scale scoreReporting odds ratioStroke-TPIMRS scoreIntracerebral hemorrhageClinical scoresStroke patientsExcellent outcomesRt-PABI scoreIndex scoreOutcomesTURN: A Simple Predictor of Symptomatic Intracerebral Hemorrhage After IV Thrombolysis
Asuzu D, Nyström K, Amin H, Schindler J, Wira C, Greer D, Chi NF, Halliday J, Sheth KN. TURN: A Simple Predictor of Symptomatic Intracerebral Hemorrhage After IV Thrombolysis. Neurocritical Care 2015, 23: 166-171. PMID: 25869481, DOI: 10.1007/s12028-015-0131-z.Peer-Reviewed Original ResearchConceptsSymptomatic intracerebral hemorrhageBaseline NIHSS scorePrestroke mRS scoreNIHSS scoreMRS scoreIntracerebral hemorrhageRt-PAOdds ratioYale-New Haven HospitalNINDS rt-PA trialIschemic stroke patientsIschemic stroke treatmentIndependent predictorsStroke treatmentStroke patientsClinical parametersPlatelet countHyperacute strokeDerivation datasetThrombolysisLogistic regressionSubstantial riskNew scoreCharacteristic curveHemorrhage