2017
Adipose tissue macrophages impair preadipocyte differentiation in humans
Liu LF, Craig CM, Tolentino LL, Choi O, Morton J, Rivas H, Cushman SW, Engleman EG, McLaughlin T. Adipose tissue macrophages impair preadipocyte differentiation in humans. PLOS ONE 2017, 12: e0170728. PMID: 28151993, PMCID: PMC5289462, DOI: 10.1371/journal.pone.0170728.Peer-Reviewed Original ResearchConceptsImpaired adipocyte differentiationSystemic insulin resistanceInsulin resistanceAdipocyte differentiationPreadipocyte differentiationMacrophage removalImpaired preadipocyte differentiationProinflammatory immune cellsAdipose tissue inflammationAbsence of CD14Insulin-resistant humansAdipose tissue samplesOil Red ODifferentiation of preadipocytesBariatric surgeryProinflammatory cytokinesInflammatory cytokinesTissue inflammationImmune cellsCytokine secretionAdiponectin secretionAdipogenic gene expressionPhysiologic mechanismsAdipose tissueVAT adipocytes
2015
Lipids and bariatric procedures part 1 of 2: Scientific statement from the National Lipid Association, American Society for Metabolic and Bariatric Surgery, and Obesity Medicine Association: EXECUTIVE SUMMARY
Bays HE, Jones PH, Jacobson TA, Cohen DE, Orringer CE, Kothari S, Azagury DE, Morton J, Nguyen NT, Westman EC, Horn DB, Scinta W, Primack C. Lipids and bariatric procedures part 1 of 2: Scientific statement from the National Lipid Association, American Society for Metabolic and Bariatric Surgery, and Obesity Medicine Association: EXECUTIVE SUMMARY. Journal Of Clinical Lipidology 2015, 10: 15-32. PMID: 26892119, DOI: 10.1016/j.jacl.2015.12.003.Peer-Reviewed Original ResearchConceptsNational Lipid AssociationObesity Medicine AssociationBariatric proceduresLipid levelsBariatric surgeryScientific statementCholesterol metabolismCardiovascular disease risk factorsDisease risk factorsBile acid metabolismAmerican SocietyLipid benefitsGut hormonesImmune factorsRisk factorsCardiovascular diseaseLipid associationIntestinal microbiotaEndocrine factorsBile acidsExecutive summaryLipid effectsTrace element deficienciesAcid metabolismObesityLipids and bariatric procedures part 1 of 2: Scientific statement from the National Lipid Association, American Society for Metabolic and Bariatric Surgery, and Obesity Medicine Association: FULL REPORT
Bays HE, Jones PH, Jacobson TA, Cohen DE, Orringer CE, Kothari S, Azagury DE, Morton J, Nguyen NT, Westman EC, Horn DB, Scinta W, Primack C. Lipids and bariatric procedures part 1 of 2: Scientific statement from the National Lipid Association, American Society for Metabolic and Bariatric Surgery, and Obesity Medicine Association: FULL REPORT. Journal Of Clinical Lipidology 2015, 10: 33-57. PMID: 26892120, DOI: 10.1016/j.jacl.2015.12.002.Peer-Reviewed Original ResearchConceptsNational Lipid AssociationObesity Medicine AssociationBariatric proceduresLipid levelsBariatric surgeryScientific statementCholesterol metabolismCardiovascular disease risk factorsDisease risk factorsBile acid metabolismAmerican SocietyLipid benefitsGut hormonesImmune factorsRisk factorsLipid associationIntestinal microbiotaEndocrine factorsBile acidsLipid effectsTrace element deficienciesFull reportAcid metabolismObesitySurgery
2014
T-Cell Profile in Adipose Tissue Is Associated With Insulin Resistance and Systemic Inflammation in Humans
McLaughlin T, Liu LF, Lamendola C, Shen L, Morton J, Rivas H, Winer D, Tolentino L, Choi O, Zhang H, Hui Yen Chng M, Engleman E. T-Cell Profile in Adipose Tissue Is Associated With Insulin Resistance and Systemic Inflammation in Humans. Arteriosclerosis Thrombosis And Vascular Biology 2014, 34: 2637-2643. PMID: 25341798, PMCID: PMC4445971, DOI: 10.1161/atvbaha.114.304636.Peer-Reviewed Original ResearchConceptsCD8 T cellsSubcutaneous adipose tissueT cell profileInsulin resistanceT cellsAdipose tissueSystemic inflammationPeripheral bloodPlasma high-sensitivity C-reactive protein concentrationsHigh-sensitivity C-reactive protein concentrationsAnti-inflammatory T cellsAnti-inflammatory interleukin-10C-reactive protein concentrationsDiet-induced obese miceObesity-associated metabolic diseasesInsulin-mediated glucose disposalProinflammatory T helperPlasma interleukin-6T cell subsetsInsulin suppression testT-cell phenotypeSystemic insulin resistanceAdipose tissue biopsiesObese human subjectsReal-time polymerase chain reaction