Featured Publications
2-Year Outcomes After Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients
Forrest JK, Deeb GM, Yakubov SJ, Rovin JD, Mumtaz M, Gada H, O'Hair D, Bajwa T, Sorajja P, Heiser JC, Merhi W, Mangi A, Spriggs DJ, Kleiman NS, Chetcuti SJ, Teirstein PS, Zorn GL, Tadros P, Tchétché D, Resar JR, Walton A, Gleason TG, Ramlawi B, Iskander A, Caputo R, Oh JK, Huang J, Reardon MJ. 2-Year Outcomes After Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients. Journal Of The American College Of Cardiology 2022, 79: 882-896. PMID: 35241222, DOI: 10.1016/j.jacc.2021.11.062.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementEvolut Low Risk trialLow-risk trialsAortic valve replacementPrimary endpointRisk trialsCause mortalityValve replacementTranscatheter Versus Surgical Aortic Valve ReplacementLow surgical risk patientsSurgical aortic valve replacementIndependent clinical events committeeEchocardiographic core laboratoryKaplan-Meier ratesSevere aortic stenosisClinical events committeeLow-risk patientsCause mortality ratesSelf-expanding valvesDisabling strokeEchocardiographic outcomesSurgical AVRTAVR groupSurgery groupAdverse eventsPropensity-Matched Outcomes Comparing TAVR in Bicuspid vs Surgery in Tricuspid Aortic Valve Stenosis
Deeb G, Yakubov S, Reardon M, Ramlawi B, Chetcuti S, Kleiman N, Zahr F, Song H, Gada H, Mumtaz M, Ito S, Huang J, Forrest J. Propensity-Matched Outcomes Comparing TAVR in Bicuspid vs Surgery in Tricuspid Aortic Valve Stenosis. Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 2: 100525. PMID: 39132531, PMCID: PMC11307701, DOI: 10.1016/j.jscai.2022.100525.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementSurgical aortic valve replacementAortic valve stenosisTricuspid aortic valve stenosisBicuspid aortic valve stenosisAortic valve replacementSAVR patientsValve replacementValve stenosisEvolut Low Risk trialIndependent clinical events committeeLow-risk trialsSerious adverse eventsSevere aortic regurgitationClinical events committeeLow surgical riskLow-risk patientsIndependent core laboratoryEffective orifice areaTAVR groupValve gradientAdverse eventsAortic regurgitationSurgical riskEvents committee3-Year Outcomes After Transcatheter or Surgical Aortic Valve Replacement in Low-Risk Patients With Aortic Stenosis
Forrest J, Deeb G, Yakubov S, Gada H, Mumtaz M, Ramlawi B, Bajwa T, Teirstein P, DeFrain M, Muppala M, Rutkin B, Chawla A, Jenson B, Chetcuti S, Stoler R, Poulin M, Khabbaz K, Levack M, Goel K, Tchétché D, Lam K, Tonino P, Ito S, Oh J, Huang J, Popma J, Kleiman N, Reardon M, Investigators L, Sorajja P, Byrne T, Kirshner M, Bajwa T, Crouch J, Coselli J, Silva G, Hebeler R, Stoler R, Islam A, Rousou A, Poulin M, Khabbaz K, Bladergroen M, Fail P, Netherland D, Lam K, Tonino W, Sudre A, Berthoumieu P, Tchétché D, Khalili H, Hughes G, Harrison J, De A, Tsau P, van Mieghem N, Larbalestier R, Yong G, Agarwal S, Martin W, Park S, Kleiman N, Reardon M, Mohammadi S, Rodes-Cabau J, Sparling J, Elkins C, Ganzel B, Matthews R, Starnes V, Ando K, Chevalier B, Farge A, DeFrain M, Muppala M, Combs W, Bagur R, Chu M, Fontana G, Dev V, Leya F, Tuchek J, Inglessis I, Jassar A, Piazza N, Lacappelle K, Steinberg D, Katz M, Wang J, Kozina J, Slachman F, Merritt R, Chawla A, Jensen B, Alvarez J, Gooley R, Smith J, Ibrahim R, Cartier R, Rovin J, Fujita T, Rutkin B, Yakubov S, Song H, Zahr F, Miyagawa S, Rajagopal V, Kauten J, Gada H, Mumtaz M, Bhindi R, Brady P, Batra S, Davis T, Iskander A, Heimansohn D, Hermiller J, Takamisawa I, Haldis T, Yamazaki S, Teirstein P, Tada N, Saito S, Merhi W, Leung S, Muller D, Heijmen R, Petrossian G, Robinson N, Knight P, Ling F, Radhakrishnan S, Fremes S, Lehr E, Gafoor S, Noel T, Walton A, Resar J, Adams D, Sharma S, Lilly S, Tadros P, Zorn G, Dauerman H, Ittleman F, Horlick E, Feindel C, Welt F, Sharma V, Markowitz A, Carroll J, Fullerton D, Griffith B, Gupta A, de Marchena E, Salerno T, Chetcuti S, Deeb G, Sultan I, Goel K, Pasupati S, Kon N, Zhao D, Ramlawi B, Forrest J. 3-Year Outcomes After Transcatheter or Surgical Aortic Valve Replacement in Low-Risk Patients With Aortic Stenosis. Journal Of The American College Of Cardiology 2023, 81: 1663-1674. PMID: 36882136, DOI: 10.1016/j.jacc.2023.02.017.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementLow-risk patientsCause mortalityPrimary endpointParavalvular regurgitationValve replacementEvolut Low Risk trialLow surgical risk patientsSurgical aortic valve replacementGreater paravalvular regurgitationLow-risk trialsData comparing outcomesLow-risk studiesSupra-annular valveEchocardiographic outcomesSecondary endpointsSurgery groupTAVR patientsRisk patientsSurgery patientsAortic stenosisPacemaker placementTreatment armsMean age
2024
Four-Year Outcomes After Transcatheter or Contemporary Surgical Aortic Valve Replacement from the Evolut Low Risk Trial
Ramlawi B, Deeb G, Mumtaz M, Bajwa T, Rovin J, Yakubov S, Jung Y, Reardon M, Forrest J. Four-Year Outcomes After Transcatheter or Contemporary Surgical Aortic Valve Replacement from the Evolut Low Risk Trial. Journal Of Thoracic And Cardiovascular Surgery 2024 PMID: 39181441, DOI: 10.1016/j.jtcvs.2024.08.023.Peer-Reviewed Original Research
2023
Impact of aortic valve replacement in symptomatic low-risk patients with less than severe aortic stenosis
Ito S, Laham R, Nkomo V, Forrest J, Reardon M, Little S, Mumtaz M, Gada H, Bajwa T, Langholz D, Heiser J, Chawla A, Jenson B, Attizanni G, Markowitz A, Huang J, Oh J. Impact of aortic valve replacement in symptomatic low-risk patients with less than severe aortic stenosis. Open Heart 2023, 10: e002297. PMID: 37173100, PMCID: PMC10186477, DOI: 10.1136/openhrt-2023-002297.Peer-Reviewed Original ResearchConceptsSevere aortic stenosisAortic valve replacementAortic stenosisSymptomatic patientsValve replacementKansas City Cardiomyopathy Questionnaire overall summary scoreEvolut Low Risk trialSurgical aortic valve replacementLow-risk trialsLow-risk patientsOverall summary scoreRate of deathQuality of lifeDisabling strokeEchocardiographic evidenceIsolated AVRHaemodynamic profileClinical outcomesHaemodynamic outcomesRisk trialsClinical trialsCalcium volumeSummary scoresPatientsCore laboratory measurements
2022
Site-Level Variation and Predictors of Permanent Pacemaker Implantation Following TAVR in the Evolut Low-Risk Trial
Gada H, Vora AN, Tang GHL, Mumtaz M, Forrest JK, Laham RJ, Yakubov SJ, Deeb GM, Rammohan C, Huang J, Reardon MJ. Site-Level Variation and Predictors of Permanent Pacemaker Implantation Following TAVR in the Evolut Low-Risk Trial. Cardiovascular Revascularization Medicine 2022, 47: 48-54. PMID: 36266154, DOI: 10.1016/j.carrev.2022.10.004.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementPermanent pacemaker implantationNew permanent pacemaker implantationAortic valve replacementPPI rateValve replacementPacemaker implantationClinical outcomesBenefits of TAVRSelf-expanding transcatheter aortic valve replacementBaseline right bundle branch blockRate of PPIEvolut Low Risk trialSurgical aortic valve replacementRight bundle branch blockLow-risk trialsLeft coronary sinusLow-risk patientsBundle branch blockEvolut valvesCoronary sinusGeneral anesthesiaConduction disordersBranch blockProcedural characteristicsPropensity-Matched 1-Year Outcomes Following Transcatheter Aortic Valve Replacement in Low-Risk Bicuspid and Tricuspid Patients
Deeb GM, Reardon MJ, Ramlawi B, Yakubov SJ, Chetcuti SJ, Kleiman NS, Mangi AA, Zahr F, Song HK, Gada H, Mumtaz M, Heiser J, Merhi W, Murrah CP, Noel T, Kirshner M, Byrne T, Ito S, Huang J, Forrest JK. Propensity-Matched 1-Year Outcomes Following Transcatheter Aortic Valve Replacement in Low-Risk Bicuspid and Tricuspid Patients. JACC Cardiovascular Interventions 2022, 15: 511-522. PMID: 35272776, DOI: 10.1016/j.jcin.2021.10.027.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementValve replacementAortic stenosisTricuspid patientsOutcomes Following Transcatheter Aortic Valve ReplacementEvolut Low Risk trialLow surgical risk patientsIndependent clinical events committeeBicuspid aortic stenosisLow-risk trialsSurgical risk patientsTricuspid aortic stenosisPropensity-matched groupsSerious adverse eventsClinical events committeeIndependent core laboratoryBicuspid aortic valveEffective orifice areaTricuspid groupCause mortalityPrimary endpointTAVR patientsAdverse eventsRisk patientsTHE ROLE OF TRANSCATHETER AORTIC VALVE REPLACEMENT IN LOW-FLOW, LOW-GRADIENT AORTIC STENOSIS: INSIGHTS FROM THE EVOLUT LOW RISK TRIAL
Anwaruddin S, Forrest J, Gada H, Mumtaz M, Huang J, Maini B, Oh J, Ito S, Kleiman N, Reardon M. THE ROLE OF TRANSCATHETER AORTIC VALVE REPLACEMENT IN LOW-FLOW, LOW-GRADIENT AORTIC STENOSIS: INSIGHTS FROM THE EVOLUT LOW RISK TRIAL. Journal Of The American College Of Cardiology 2022, 79: 653. DOI: 10.1016/s0735-1097(22)01644-8.Peer-Reviewed Original Research
2020
Impact of Repositioning on Outcomes Following Transcatheter Aortic Valve Replacement With a Self-Expandable Valve
Attizzani GF, Dallan LAP, Markowitz A, Yakubov SJ, Deeb GM, Reardon MJ, Forrest JK, Mangi AA, Huang J, Popma JJ. Impact of Repositioning on Outcomes Following Transcatheter Aortic Valve Replacement With a Self-Expandable Valve. JACC Cardiovascular Interventions 2020, 13: 1816-1824. PMID: 32763073, DOI: 10.1016/j.jcin.2020.04.028.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve StenosisFemaleHeart Valve ProsthesisHumansMaleMultidetector Computed TomographyProsthesis DesignRandomized Controlled Trials as TopicRetrospective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexStrokeTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsEvolut RPrimary outcomeValve Academic Research Consortium-2Academic Research Consortium-2Evolut Low Risk trialPrior percutaneous coronary interventionTranscatheter aortic valve replacementEvolut PRO valveLow-risk trialsThoracic Surgeons scoreAortic valve replacementPercutaneous coronary interventionSelf-expandable valvesTranscatheter aortic valveDisabling strokeEvolut valvesSURTAVI trialCause mortalityTrial patientsCoronary interventionSecondary outcomesSurgeons scoreValve replacementClinical outcomesAortic valve