2024
Protective Biomechanical and Histological Changes in the False Lumen Wall in Chronic Type B Aortic Dissection
Dong H, Liu M, Cebull H, Chhabra A, Zhou Y, Piccinelli M, Oshinski J, Elefteriades J, Gleason R, Leshnower B. Protective Biomechanical and Histological Changes in the False Lumen Wall in Chronic Type B Aortic Dissection. JTCVS Open 2024 DOI: 10.1016/j.xjon.2024.11.012.Peer-Reviewed Original ResearchChronic phaseChronic type B aortic dissectionType B aortic dissectionHistological changesB aortic dissectionIncreased aortic stiffnessAcute to chronic phaseAortic stiffnessDecreased elastinIncreased collagenQuantification of collagenBiaxial tension testsStress-strain curvesBiomechanical stiffnessTension testsAssess stiffnessHuman tissuesCollagenEditorial: Novel biomarkers in acute aortic dissection
Georgiadou P, Sbarouni E, Elefteriades J. Editorial: Novel biomarkers in acute aortic dissection. Frontiers In Cardiovascular Medicine 2024, 11: 1457521. PMID: 39087070, PMCID: PMC11288941, DOI: 10.3389/fcvm.2024.1457521.Peer-Reviewed Original ResearchThe use of 4-dimensional flow magnetic resonance imaging and fluid structure interaction analysis to predict failure of medical therapy in acute uncomplicated type B aortic dissection
Cebull H, Liu M, Piccinelli M, Dong H, Naeem M, Du Y, Oshinski J, Gleason R, Elefteriades J, Leshnower B. The use of 4-dimensional flow magnetic resonance imaging and fluid structure interaction analysis to predict failure of medical therapy in acute uncomplicated type B aortic dissection. JTCVS Techniques 2024, 27: 40-44. PMID: 39478892, PMCID: PMC11519730, DOI: 10.1016/j.xjtc.2024.06.019.Peer-Reviewed Original Research4D Flow MRI-Derived Hemodynamic Parameters Related to Growth in Acute Type B Aortic Dissections
Cebull H, Liu M, Dong H, Elefteriades J, Gleason R, Piccinelli M, Oshinski J, Leshnower B. 4D Flow MRI-Derived Hemodynamic Parameters Related to Growth in Acute Type B Aortic Dissections. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2024 DOI: 10.58530/2024/4770.Peer-Reviewed Original ResearchType B aortic dissectionAcute type B aortic dissectionB aortic dissectionAortic growthHigh-risk patientsPreemptive treatmentSurgical outcomesTBAD patientsIn vivo hemodynamicsStratify riskHemodynamic parametersImprove outcomesHemodynamic markersAcute patientsPatientsDissectionFlow MRIHemodynamic metricsTearsMRI dataOutcomesThe role of anatomic shape features in the prognosis of uncomplicated type B aortic dissection initially treated with optimal medical therapy
Liu M, Dong H, Mazlout A, Wu Y, Kalyanasundaram A, Oshinski J, Sun W, Elefteriades J, Leshnower B, Gleason R. The role of anatomic shape features in the prognosis of uncomplicated type B aortic dissection initially treated with optimal medical therapy. Computers In Biology And Medicine 2024, 170: 108041. PMID: 38330820, PMCID: PMC10932856, DOI: 10.1016/j.compbiomed.2024.108041.Peer-Reviewed Original ResearchConceptsType B aortic dissectionTreated with optimal medical therapyAortic growth rateOptimal medical therapyUncomplicated type B aortic dissectionB aortic dissectionMedical therapyCT scanPatients' long-term survivalType B aortic dissection patientsLong-term outcomesLong-term survivalFailure groupAortic expansionChronic phaseFailure patientsPatientsCT imagesTherapyDissectionStatistical shape modelFailurePrognosisScanningRegression
2023
Significant unfavorable geometrical changes in ascending aorta despite stable diameter at follow-up.
Kalogerakos P, Pirentis A, Papaharilaou Y, Skiadas C, Karantanas A, Mojibian H, Marketou M, Kochiadakis G, Elefteriades J, Lazopoulos G. Significant unfavorable geometrical changes in ascending aorta despite stable diameter at follow-up. Hellenic Journal Of Cardiology 2023 PMID: 37931701, DOI: 10.1016/j.hjc.2023.10.007.Peer-Reviewed Original ResearchDecision-making in aortic disease
Wu J, Zafar M, Elefteriades J. Decision-making in aortic disease. European Heart Journal 2023, 45: 633-634. PMID: 37936301, DOI: 10.1093/eurheartj/ehad699.Peer-Reviewed Original Research“Big Data” Analyses Underlie Clinical Discoveries at the Aortic Institute
Zafar M, Ziganshin B, Li Y, Ostberg N, Rizzo J, Tranquilli M, Mukherjee S, Elefteriades J. “Big Data” Analyses Underlie Clinical Discoveries at the Aortic Institute. The Yale Journal Of Biology And Medicine 2023, 96: 427-440. PMID: 37780996, PMCID: PMC10524815, DOI: 10.59249/lndz2964.Peer-Reviewed Original ResearchConceptsBig dataArtificial intelligenceThoracic aortic aneurysmArtificial intelligence techniquesData setsAortic aneurysmLarge clinical data setsIntelligence techniquesAdvanced machineYale-New Haven HospitalClinical data setsAortic aneurysm patientsAortic root dilatationBicuspid aortic valveProspective clinical databaseNew Haven HospitalLarge genetic data setsIntelligenceSequencing filesThoracoabdominal aortaAortic dilatationMale patientsRisk prognosticationRoot dilatationSurgical treatmentSafety of cerebrospinal fluid drainage in descending and thoracoabdominal aortic replacement surgery
Nasir A, Zafar M, Abdelbaky M, Papanikolaou D, Ellauzi H, Shaikh M, Ziganshin B, Elefteriades J. Safety of cerebrospinal fluid drainage in descending and thoracoabdominal aortic replacement surgery. Annals Of Cardiothoracic Surgery 2023, 12: 47683-47483. PMID: 37817851, PMCID: PMC10561341, DOI: 10.21037/acs-2023-scp-0121.Peer-Reviewed Original ResearchCerebrospinal fluid drainageThoracoabdominal aortic aneurysmsSpinal cord injuryOpen surgical repairSurgical repairElectronic health recordsAortic aneurysmFluid drainagePersistent cerebrospinal fluid leakageAortic replacement surgeryMean hospital lengthSpinal cord protectionRetrospective chart reviewThoracic aortic aneurysmThoracoabdominal aortic diseaseCerebrospinal fluid leakageLong-term survivalHospital mortalityHospital lengthPermanent paraplegiaChart reviewMinor complicationsPatient agePostoperative courseCutaneous fistulaSynergistic integration of deep neural networks and finite element method with applications of nonlinear large deformation biomechanics
Liang L, Liu M, Elefteriades J, Sun W. Synergistic integration of deep neural networks and finite element method with applications of nonlinear large deformation biomechanics. Computer Methods In Applied Mechanics And Engineering 2023, 416: 116347. PMID: 38370344, PMCID: PMC10871671, DOI: 10.1016/j.cma.2023.116347.Peer-Reviewed Original ResearchFinite element methodInverse problemPhysics-informed loss functionTime-sensitive clinical applicationsTraditional finite element methodElement methodMaterial parameter identificationForward problemSurrogate modelParameter identificationEquilibrium equationsOptimal solutionDNN solutionsTest casesOutput mappingParameter identification accuracyNeural networkDeep neural networksNon-negligible errorsFEM frameworkPatient-specific geometryFinite element analysisInverse methodInverse approachForward modelExtensive Proximal Thoracic Endovascular Aortic Repair Coverage Is Associated with Adverse Cardiac Impact
Harris S, Aboian E, Kostiuk V, Cardella J, Guzman R, Chaar C, Strosberg D, Elefteriades J. Extensive Proximal Thoracic Endovascular Aortic Repair Coverage Is Associated with Adverse Cardiac Impact. Journal Of Vascular Surgery 2023, 77: e279-e280. DOI: 10.1016/j.jvs.2023.03.389.Peer-Reviewed Original ResearchThe natural history of aortic root aneurysms.
Ziganshin B, Kargin N, Zafar M, Elefteriades J. The natural history of aortic root aneurysms. ASVIDE 2023, 10: 99-99. DOI: 10.21037/asvide.2023.099.Peer-Reviewed Original ResearchPyTorch-FEA: Autograd-enabled finite element analysis methods with applications for biomechanical analysis of human aorta
Liang L, Liu M, Elefteriades J, Sun W. PyTorch-FEA: Autograd-enabled finite element analysis methods with applications for biomechanical analysis of human aorta. Computer Methods And Programs In Biomedicine 2023, 238: 107616. PMID: 37230048, PMCID: PMC10330852, DOI: 10.1016/j.cmpb.2023.107616.Peer-Reviewed Original ResearchConceptsDeep neural networksFinite element analysisFEA codeImproved loss functionInverse methodFinite element analysis methodInverse problemCommercial FEA software packageElement analysis methodFEA software packageCommercial FEA packageNew libraryNeural networkPerformance issuesFEA packageNew inverse methodBiomechanical analysisComputational timeFEA methodLoss functionSolid mechanicsDeformation analysisSoftware packageInverse analysisSeries of applicationsCommentary: Pulling back the curtain: Need for reoperation after valve-sparing aortic root replacement
Elefteriades J. Commentary: Pulling back the curtain: Need for reoperation after valve-sparing aortic root replacement. Journal Of Thoracic And Cardiovascular Surgery 2023, 167: 1241-1243. PMID: 37169062, DOI: 10.1016/j.jtcvs.2023.05.004.Peer-Reviewed Original ResearchApixaban or Warfarin in Patients with an On-X Mechanical Aortic Valve.
Wang T, Svensson L, Wen J, Vekstein A, Gerdisch M, Rao V, Moront M, Johnston D, Lopes R, Chavez A, Ruel M, Blackstone E, Becker R, Thourani V, Puskas J, Al-Khalidi H, Cable D, Elefteriades J, Pochettino A, Wolfe J, Graeve A, Sultan I, Sabe A, Michelena H, Alexander J. Apixaban or Warfarin in Patients with an On-X Mechanical Aortic Valve. NEJM Evidence 2023, 2: evidoa2300067. PMID: 38320162, DOI: 10.1056/evidoa2300067.Peer-Reviewed Original ResearchNatural History and Intervention Thresholds for Ascending Thoracic Aortic Aneurysm—Not an Easy Nut to Crack
Zafar M, Elefteriades J. Natural History and Intervention Thresholds for Ascending Thoracic Aortic Aneurysm—Not an Easy Nut to Crack. JAMA Cardiology 2023, 8: 512-512. PMID: 36920367, DOI: 10.1001/jamacardio.2023.0153.Peer-Reviewed Original ResearchThe natural history of aortic root aneurysms
Ziganshin B, Kargin N, Zafar M, Elefteriades J. The natural history of aortic root aneurysms. Annals Of Cardiothoracic Surgery 2023, 12: 21324-21224. PMID: 37304695, PMCID: PMC10248916, DOI: 10.21037/acs-2023-avs1-20.Peer-Reviewed Original ResearchBicuspid aortopathy does not require earlier surgical intervention
Zafar M, Wu J, Vinholo T, Li Y, Papanikolaou D, Ellauzi H, Ostberg N, Kalyanasundaram A, Kalogerakos P, Mukherjee S, Ziganshin B, Rizzo J, Elefteriades J. Bicuspid aortopathy does not require earlier surgical intervention. Journal Of Thoracic And Cardiovascular Surgery 2023, 168: 760-769.e4. PMID: 37088130, DOI: 10.1016/j.jtcvs.2023.04.017.Peer-Reviewed Original ResearchBicuspid aortic valveAdverse aortic eventsEvent-free survivalAortic eventsAortic sizeAortic diameterAortic growth rateEarly surgical interventionLong-term complicationsRisk of complicationsThoracic aortic aneurysmAortic deathComplication rateSurgical repairOperative repairProphylactic surgerySurgical interventionAortic aneurysmAortic valveSurgical correctionBicuspid aortopathyRelative riskExpert centersTAV-ATAAPatientsAortic Size at the Time of Type A and Type B Dissections
Perez Z, Zafar M, Velasco J, Sonsino A, Ellauzi H, John C, Kalyanasundaram A, Ziganshin B, Elefteriades J. Aortic Size at the Time of Type A and Type B Dissections. The Annals Of Thoracic Surgery 2023, 116: 262-268. PMID: 37062339, DOI: 10.1016/j.athoracsur.2023.03.037.Peer-Reviewed Original ResearchConceptsType B dissectionTime of dissectionB dissectionAortic sizeAortic diameterBicuspid aortic valveThoracic aortic aneurysmAortic interventionAortic dissectionSurgical interventionAortic aneurysmFemale sexAortic valveThoracic aortaProphylactic repairUnadjusted regressionLeft shiftLogistic regressionDissectionNew guidelinesType ASize criteriaOddsInterventionTime of typesExtended law of laplace for measurement of the cloverleaf anatomy of the aortic root
Ban E, Kalogerakos P, Khosravi R, Ziganshin B, Ellauzi H, Ramachandra A, Zafar M, Humphrey J, Elefteriades J. Extended law of laplace for measurement of the cloverleaf anatomy of the aortic root. The International Journal Of Cardiovascular Imaging 2023, 39: 1345-1356. PMID: 37046157, PMCID: PMC10250276, DOI: 10.1007/s10554-023-02847-5.Peer-Reviewed Original Research