Protective Biomechanical and Histological Changes in the False Lumen Wall in Chronic Type B Aortic Dissection
Dong H, Liu M, Cebull H, Chhabra A, Zhou Y, Piccinelli M, Oshinski J, Elefteriades J, Gleason R, Leshnower B. Protective Biomechanical and Histological Changes in the False Lumen Wall in Chronic Type B Aortic Dissection. JTCVS Open 2024 DOI: 10.1016/j.xjon.2024.11.012.Peer-Reviewed Original ResearchChronic phaseChronic type B aortic dissectionType B aortic dissectionHistological changesB aortic dissectionIncreased aortic stiffnessAcute to chronic phaseAortic stiffnessDecreased elastinIncreased collagenQuantification of collagenBiaxial tension testsStress-strain curvesBiomechanical stiffnessTension testsAssess stiffnessHuman tissuesCollagenThe role of anatomic shape features in the prognosis of uncomplicated type B aortic dissection initially treated with optimal medical therapy
Liu M, Dong H, Mazlout A, Wu Y, Kalyanasundaram A, Oshinski J, Sun W, Elefteriades J, Leshnower B, Gleason R. The role of anatomic shape features in the prognosis of uncomplicated type B aortic dissection initially treated with optimal medical therapy. Computers In Biology And Medicine 2024, 170: 108041. PMID: 38330820, PMCID: PMC10932856, DOI: 10.1016/j.compbiomed.2024.108041.Peer-Reviewed Original ResearchConceptsType B aortic dissectionTreated with optimal medical therapyAortic growth rateOptimal medical therapyUncomplicated type B aortic dissectionB aortic dissectionMedical therapyCT scanPatients' long-term survivalType B aortic dissection patientsLong-term outcomesLong-term survivalFailure groupAortic expansionChronic phaseFailure patientsPatientsCT imagesTherapyDissectionStatistical shape modelFailurePrognosisScanningRegression